Results 221 to 230 of about 85,965 (258)

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

Smart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li, Fuping Han, Haiqiao Huang, Danhong Zhou, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Jing Ning, Chong Peng, Xiaojun Peng   +10 more
wiley   +1 more source

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Differential expression of miRNA in histological subtype of Wilms tumor

Pediatric Surgery International, 2021
Wilms tumor is the most common renal malignancy in children and difficult to differentiate from other paediatric abdominal tumors radiologically, necessitating an invasive procedure for diagnosis. Previous studies have shown the potential role of miRNA as biomarkers for diagnosis, histological subtyping and prognosis.
Disha, Kakkar, Saumyaranjan, Mallick, Aijaz, Ahmad, Ansh, Goswami, Sandeep, Agarwala, Aditya Kumar, Gupta, V, Sreenivas, Sameer, Bakhshi, K, Devasenathipathy, Sandeep, Mathur, Deepali, Jain, Rachana, Seth, Venkateswaran K, Iyer   +12 more
openaire   +2 more sources

Differentially expressed miRNAs in bone after methotrexate treatment

Journal of Cellular Physiology, 2021
AbstractPrevious studies have shown that administration of antimetabolite methotrexate (MTX) caused a reduced trabecular bone volume and increased marrow adiposity (bone/fat switch), for which the underlying molecular mechanisms and recovery potential are unclear.
Yali Zhang, Liang Liu, Katherine A Pillman, John Hayball, Yu‐Wen Su, Cory J. Xian   +5 more
openaire   +3 more sources

Differentially expressed miRNAs in retinoblastoma

Gene, 2013
MicroRNAs (miRNAs) are short non-coding RNA transcripts that have the ability to regulate the expression of target genes, and have been shown to influence the development of various tumors. The purpose of our study is to identify aberrantly expressed miRNAs in retinoblastoma for the discovery of potential therapeutic targets for this disease, and to ...
Joshua, Martin, Paul, Bryar, Marilyn, Mets, Joanna, Weinstein, Aunica, Jones, Alissa, Martin, Elio F, Vanin, Denise, Scholtens, Fabricio F, Costa, Marcelo B, Soares, Nikia A, Laurie   +10 more
openaire   +2 more sources

Differential expression of miRNAs and their relation to active tuberculosis

Tuberculosis, 2015
The aim of this work was to screen miRNA signatures dysregulated in tuberculosis to improve our understanding of the biological role of miRNAs involved in the disease. Datasets deposited in publically available databases from microarray studies on infectious diseases and malignancies were retrieved, screened, and subjected to further analysis.
Zhihong, Xu, Aiping, Zhou, Jinjing, Ni, Qiufen, Zhang, Ying, Wang, Jie, Lu, Wenjuan, Wu, Petros C, Karakousis, Shuihua, Lu, Yufeng, Yao   +9 more
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Differentially expressed miRNAs and potential therapeutic targets for asthenospermia

Andrologia, 2021
Asthenozoospermia is detected in 40% of infertile men, and characterised by low sperm motility. MicroRNAs (miRNAs) play essential roles in spermatogenesis, but little is known regarding the function of seminal plasma miRNAs in asthenozoospermia. In this study, we collected seminal plasma samples from patients with asthenospermia and healthy men and ...
Gaozhao Liang, Qianqian Wang, Guohui Zhang, Zhongxiang Li, Qing Wang   +4 more
openaire   +2 more sources

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA‐1 in Met expression

Journal of Orthopaedic Research, 2010
AbstractEmerging evidence suggests that microRNA (miRNA) expression signatures in cancer may have important diagnostic, prognostic, and therapeutic value, but there is no data on miRNA expression in chordoma. The purpose of this study was to identify the role of miRNAs in human chordoma.
Zhenfeng, Duan, Edwin, Choy, G Petur, Nielsen, Andrew, Rosenberg, John, Iafrate, Cao, Yang, Joe, Schwab, Henry, Mankin, Ramnik, Xavier, Francis J, Hornicek   +9 more
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Differentially expressed miRNAs associated with generalized aggressive periodontitis

Clinical Oral Investigations, 2023
This study aimed to investigate miRNA expression profiles in individuals with periodontitis which is a chronic inflammatory condition affecting the integrity of the periodontal attachment. miRNAs play a crucial role in gene regulation through various mechanisms, making them potential diagnostic markers and therapeutic targets for various diseases.A ...
Işik, Elif Büşra, Cine, Naci, Özer, Tolgahan, Sunnetci-Akkoyunlu, Deniz, Guzeldemir-Akcakanat, Esra, Balta-Uysal, VECİHE MERVE   +5 more
openaire   +3 more sources

Differential expression of gut miRNAs in idiopathic Parkinson's disease

Parkinsonism & Related Disorders, 2021
In the present work, we aimed to investigate the expression of microRNAs (miRNAs) in routine colonic biopsies obtained from patients with idiopathic Parkinson's disease (PD) and to address their value as a diagnostic biomarker for PD and their mechanistic contribution to PD onset and progression.Patients with PD (n = 13) and healthy controls (n = 17 ...
Anna Kurz, Rohit Kumar, Bernd H. Northoff, Catharina Wenk, Jörg Schirra, Sainitin Donakonda, Günter U. Höglinger, Johannes Schwarz, Verena Rozanski, Rainer Hübner, Kai Bötzel, Lesca Miriam Holdt, Thomas Koeglsperger   +12 more
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Differential expression of miRNAs in rhabdomyosarcoma and malignant rhabdoid tumor

Experimental Cell Research, 2012
Alveolar rhabdomyosarcoma (RMA) and malignant rhabdoid tumor (MRT) have a frequent metastatic spread and a poor prognosis. Aberrant miRNA expression is often found in metastatic tumors. The aim of this study was to identify specific miRNA expression patterns in these tumors.
Sorin, Armeanu-Ebinger, Delia, Herrmann, Michael, Bonin, Ivo, Leuschner, Steven W, Warmann, Jörg, Fuchs, Guido, Seitz   +6 more
openaire   +3 more sources