Results 121 to 130 of about 3,296 (215)

Topical Treatment of Actinic Keratosis and Non-melanoma Skin Cancer with Phospho-sulindac and Difluoromethylornithine

, 2015
Actinic keratosis (AK), a cutaneous lesion resulting from the proliferation of atypical epidermal keratinocytes, has an incidence of 11%-26% and its prevalence is 58 million in the US alone. AK is a precursor to non-melanoma skin cancer (NMSC).
Sun, Yajing
core  

Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function

Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO).
Juan Pablo Arnoletti (12275290), Otto Phanstiel (1801117), Holly Moots (8519748), Sharifa Dinara (8519742), Kunal Shah (5999576), Paul M. Hershberger (1545562), Aiste Dobrovolskaite (11979807), David Levens (138737), Chelsea Massaro (8519733), Jenna Thomas (8519736), Eliot Sugarman (1346577), Patrick R. Maloney (1912969), Satyamaheshwar Peddibhotla (1271367), Rajiv Kumar Jha (3993509), Sally Litherland (14127867), Mukund P. Tantak (14127864)   +15 more
core   +1 more source

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism. [PDF]

ESMO Open
Piha-Paul SA, Tolcher AW, Vandross AL, Spira AI, Burns MR.   +4 more
europepmc   +1 more source

Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis. [PDF]

Clin Cancer Res
Offenbacher R, Jackson KW, Hayashi M, Zhang J, Peng D, Tan Y, Stewart TM, Ciero P, Foley J, Casero RA, Cahan P, Loeb DM.   +11 more
europepmc   +1 more source

Polyamines stimulate the protein synthesis of the translation initiation factor eIF5A2, participating in mRNA decoding, distinct from eIF5A1. [PDF]

J Biol Chem
Suzuki M, Suzuki T, Nakano Y, Matsumoto K, Manaka H, Komeno M, Tamori S, Sato A, Dohmae N, Akimoto K, Miyazaki S, Suda T, Toida T, Kashiwagi K, Igarashi K, Higashi K.   +15 more
europepmc   +1 more source

Recent Trends in Clinical Trials for Pediatric Sarcoma in the United States: An Analysis of ClinicalTrials.gov. [PDF]

Children (Basel)
Alkhawaldeh K, Thorpe S, Cho S, Miller A, Alleyne M, Jones J, Beaupin L, Gupta A, Metts J.   +8 more
europepmc   +1 more source

Chemoprevention in Skin Cancer: What Advice? [PDF]

Cancers (Basel)
Ortiz-Brugués A, Orte Cano C, Corbella L, Alamon-Reig F, Martí-Martí I, Ayguasanosa-Avila M, Hernández-Santacana M, Giavedoni P, Aguilera P, Carrera C.   +9 more
europepmc   +1 more source

Reprogramming neuroblastoma by diet-enhanced polyamine depletion. [PDF]

Nature
Cherkaoui S, Turn CS, Yuan Y, Lu W, Yang L, McBride MJ, Eigenmann C, Allen GE, Panasenko OO, Zhang L, Vu A, Liu K, Li Y, Gandhi OH, Surrey LF, Kienast SD, Leidel SA, Wierer M, White E, Rabinowitz JD, Hogarty MD, Morscher RJ.   +21 more
europepmc   +1 more source

Polyamine Inhibition with DFMO: Shifting the Paradigm in Neuroblastoma Therapy. [PDF]

J Clin Med
Schramm J, Sholler C, Menachery L, Vazquez L, Saulnier Sholler G.   +4 more
europepmc   +1 more source

Polyamines as Gatekeepers of Virus Replication and Central Nervous System Homeostasis. [PDF]

Pathogens
Stacey SP, Mounce BC.
europepmc   +1 more source