Results 101 to 110 of about 3,296 (215)

Polyamines Participate in Mycorrhizal and Root Development of Citrus (Citrus tangerine) Seedlings

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2010
A pot experiment was conducted to study the effects of difluoromethylornithine (DFMO, an irreversible inhibitor of putrescine (Put) formation) alone or combination with Put on mycorrhizal and root development of Citrus tangerine seedlings inoculated with
Qiang-Sheng WU, Ying-Ning ZOU, Tian-Tian ZHAN, Chun-Yan LIU   +3 more
doaj   +1 more source

Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2013
Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents.
Altaf Mohammed, Naveena B Janakiram, Misty Brewer, Krishna Vedala, Vernon E Steele, Chinthalapally V Rao   +5 more
doaj   +1 more source

Α-Difluoromethylornithine (DFMO) treatment affects both cell proliferation and cell death in MDA-MB-231 orthotopic tumors

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages

Redox Biology
Salmonella infection entails a cascade of attacks and defence measures. After breaching the intestinal epithelial barrier, Salmonella is phagocytosed by macrophages, where the bacteria encounter multiple stresses, to which it employs relevant ...
Abhilash Vijay Nair, Anmol Singh, R.S. Rajmani, Dipshikha Chakravortty   +3 more
doaj   +1 more source

Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line

, 1994
Dilution of quiescent L1210-DFMO(r) (difluoromethylornithine-resistant) cells in fresh medium containing serum led to the induction of ornithine decarboxylase (ODC) and to the expression of its mRNA, as determined by a sensitive solution-hybridization ...
Carboni L., Campana G., Guarnieri C., Spampinato S., Flamigni F.   +4 more
core   +1 more source

Difluoromethylornithine Combined With A Polyamine Transport Inhibitor Is Effective Against Gemcitabine Resistant Pancreatic Cancer

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is highly chemo-resistant and has an extremely poor patient prognosis, with a survival rate at five years of \u3c8%. There remains an urgent need for innovative treatments.
Pandey, Veethika, Gitto, Sarah B., Oyer, Jeremiah L., Copik, Alicja J., Hogan, Frederick C.   +4 more
core   +1 more source

Isolation and characterization of human breast adenocarcinoma cells made resistant to α-difluoromethylornithine

, 2000
Human breast adenocarcinoma cells MCF-7 were selected for resistance to ornithine decarboxylase (ODC) inhibitor, α-difluoromethylornithine (DFMO). Stepwise increments of the concentration of DFMO resulted in selection of MCF-7 cells that were capable of ...
Khurana, Kamal K., Das, Bhagwan, Vig, Monika, Madhubala, Rentala   +3 more
core   +1 more source

Effect of difluoromethylornithine on thyroid function in rats.

Journal of Ayub Medical College, Abbottabad : JAMC, 2011
A variety of stimuli cause a rapid increase in polyamine synthesis by increasing an enzyme ornithine decarboxylase required for the biosynthetic pathway of protein synthesis. Difluoromethyl ornithine is a selective inhibitor of this enzyme and hence arrests cell replication strikingly.
Rehana, Rehman, Rakhshaan, Khan, Muhammad Saleh, Soomro, Muhammad, Aslam   +3 more
openaire   +1 more source

Α-Difluoromethylornithine (DFMO) delays orthotopic tumor growth of MDA-MB-231 cells

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

Properties of L1210 cells resistant to α-difluoromethylornithine [PDF]

, 1988
L1210 cells were selected for resistance to the ornithine decarboxylase (ODC) inhibitor, α-difluromethylornithine. When grown in the absence of the inhibitor, these cells possessed very high ornithine decarboxylase levels.
Madhubala, Rentala, Pegg, Anthony E., Secrist III., John A.   +2 more
core   +1 more source