Results 101 to 110 of about 3,859 (214)

Development of difluoromethylornithine (DFMO) as a chemoprevention agent. [PDF]

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
D,L-alpha-difluoromethylornithine (DFMO) was synthesized over 20 years ago. It was hoped that this enzyme-activated, irreversible inhibitor of ornithine decarboxylase, the first enzyme in polyamine synthesis, would be effective as a chemotherapy for hyperproliferative diseases, including cancer and/or infectious processes.
Meyskens, F L, Jr, Gerner, E W
openaire   +1 more source

Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line

, 1994
Dilution of quiescent L1210-DFMO(r) (difluoromethylornithine-resistant) cells in fresh medium containing serum led to the induction of ornithine decarboxylase (ODC) and to the expression of its mRNA, as determined by a sensitive solution-hybridization ...
Carboni L., Campana G., Guarnieri C., Spampinato S., Flamigni F.   +4 more
core   +1 more source

Polyamines Participate in Mycorrhizal and Root Development of Citrus (Citrus tangerine) Seedlings

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2010
A pot experiment was conducted to study the effects of difluoromethylornithine (DFMO, an irreversible inhibitor of putrescine (Put) formation) alone or combination with Put on mycorrhizal and root development of Citrus tangerine seedlings inoculated with
Qiang-Sheng WU, Ying-Ning ZOU, Tian-Tian ZHAN, Chun-Yan LIU   +3 more
doaj   +1 more source

Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2013
Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents.
Altaf Mohammed, Naveena B Janakiram, Misty Brewer, Krishna Vedala, Vernon E Steele, Chinthalapally V Rao   +5 more
doaj   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek, Darren, Burchmore, Richard J S, Vincent, Isabel M, Watson, David G, Barrett, Michael P, Kamleh, Mohammed A, Woods, Debra J, Wong, Pui Ee   +7 more
core  

Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages

Redox Biology
Salmonella infection entails a cascade of attacks and defence measures. After breaching the intestinal epithelial barrier, Salmonella is phagocytosed by macrophages, where the bacteria encounter multiple stresses, to which it employs relevant ...
Abhilash Vijay Nair, Anmol Singh, R.S. Rajmani, Dipshikha Chakravortty   +3 more
doaj   +1 more source

Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes

Cellular Physiology and Biochemistry, 2014
Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in polyamine synthesis and endoplasmic reticulum stress (ERS) in ...
Yan Lin, Xiaojie Zhang, Lina Wang, Yajun Zhao, Hongzhu Li, Wei Xiao, Changqing Xu, Jicheng Liu   +7 more
doaj   +1 more source

Effects of Human Interferon and α-Difluoromethylornithine on T47D Cells

Journal of Interferon Research, 1986
The effect of human interferon (IFN) and alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of eukaryotic ornithine decarboxylase, on the rate of DNA synthesis and the increase of ornithine decarboxylase activity of T47D cells was examined. It was found that IFN or DFMO alone causes little or appreciable inhibition of the [
Kyriakidis, Dimitrios, Kortsaris, A.
openaire   +3 more sources

Effect of alpha-difluoromethylornithine on DNA methylation in murine erythroleukaemic cells. Relationship to stimulation of induced differentiation.

, 1987
International audienceMurine erythroleukaemic (MEL) cells cultured with alpha-difluoromethylornithine (DFMO) accumulated decarboxylated S-adenosylmethionine(decarboxylated AdoMet).
Osborne, Howard Beverley, Papazafiri, Panagiota   +1 more
core  

Effect of difluoromethylornithine on thyroid function in rats.

Journal of Ayub Medical College, Abbottabad : JAMC, 2011
A variety of stimuli cause a rapid increase in polyamine synthesis by increasing an enzyme ornithine decarboxylase required for the biosynthetic pathway of protein synthesis. Difluoromethyl ornithine is a selective inhibitor of this enzyme and hence arrests cell replication strikingly.
Rehana, Rehman, Rakhshaan, Khan, Muhammad Saleh, Soomro, Muhammad, Aslam   +3 more
openaire   +1 more source