Results 91 to 100 of about 3,859 (214)
Technology in Cancer Research & Treatment, 2020 Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown
Mahmoud Alhosin PhD +5 more
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Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer
Journal of Cellular Biochemistry, 1995 Experimental studies have demonstrated that carcinogenesis is a multistep process in which inappropriate proliferation of cells is a critical determinant. Polyamines support sustained growth and are highly regulated in all cells. The rate limiting enzyme for this pathway is ornithine decarboxylase (ODC), an enzyme that exhibits rapid turnover, and ...
Meyskens, F L, Jr, Gerner, E W
openaire +3 more sources
, 2018 This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin +2 more
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, 2014 The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to target cancers with high polyamine requirements.
Rodriguez, Luis +4 more
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A novel mechanism of resistance to α-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine [PDF]
, 1986 Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of α-difluoromethylornithine ...
Burrone, O.R. +4 more
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Glucocorticoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells
Neoplasia: An International Journal for Oncology Research, 2002 Glucocorticoids are well-known apoptotic agents in certain classes of lymphoid cell malignancies. Reduction of intracellular polyamine levels by use of inhibitors that block polyamine synthesis slows or inhibits growth of many cells in vitro.
Aaron L. Miller +4 more
doaj +1 more source
Mode of interaction of ornithine decarboxylase with antizyme and α-difluoromethylornithine
Biochemical Pharmacology, 1984 This investigation was supported by a USPH Service Grant CA-26546, by a Research Career Award to E.S. Canellakis, and by a gift from Mr. and Mrs. J. Seward Johnson, The Johnson Seward Johnson 1961 and 1963 Charitable Trusts and by Johnson and Johnson.
Kyriakidis, Dimitrios +3 more
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Repurposing Clinically Relevant Metabolic Inhibitor Drugs, Difluoromethylornithine (DFMO) and Orlistat, for gammaherpesvirus Replication [PDF]
Viruses, including herpesviruses, contribute up to 15% of all human cancers. Murine gammaherpesvirus-68 (MHV-68), a pathogen commonly found in mice, is studied due to its shared homology with several human herpesviruses.
Paw, Lay
core
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is highly chemo-resistant and has an extremely poor patient prognosis, with a survival rate at five years of \u3c8%. There remains an urgent need for innovative treatments.
Pandey, Veethika +4 more
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PLoS ONE, 2013 Non-melanoma skin cancer (NMSC) is the most common type of skin cancer in Caucasian populations. Its increasing incidence has been a major public health concern.
Aadithya Arumugam +7 more
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