Results 91 to 100 of about 3,296 (215)

Difluoromethylornithine prevents the down-regulation of type 1 interferon receptors: A possible mechanism for a synergistic antiproliferative effect

, 1990
Type I interferon and difluoromethylornithine have been shown to exert an antiproliferative effect, both alone and in combination, in several tumor cell lines.
Lai, M. C., Minchin, R. F., Dilollo, D. L., Beilharz, M. W.   +3 more
core  

The effect of putrescine and difluoromethylornithine on cell division activity of wheat in different ploidy level

, 2005
Effects of exogenous putrescine (Put) and difluoromethylornithine (DFMO) on seed germination, root growth, mitotic activity and mitotic chromosome behavior were investigated in Triticum monococcum (2x), Triticum durum (4x) and Triticum aestivum (6x). Put

core   +1 more source

Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
doaj   +1 more source

Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways

Technology in Cancer Research & Treatment, 2020
Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown
Mahmoud Alhosin PhD, Syed Shoeb I. Razvi PhD, Ryan A. Sheikh PhD, Jalaluddin A. Khan PhD, Mazin A. Zamzami PhD, Hani Choudhry PhD   +5 more
doaj   +1 more source

Polyamine Transport Inhibitors: Design, Synthesis, And Combination Therapies With Difluoromethylornithine

, 2014
The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to target cancers with high polyamine requirements.
Rodriguez, Luis, Ocampo, Nicolette, Muth, Aaron, Archer, Jennifer Julian, Madan, Meenu   +4 more
core   +2 more sources

Effet des polyamines sur la réduction du chrome hexavalent par des souches bactériennes et leur résistance

Biotechnologie, Agronomie, Société et Environnement, 2014
Effect of polyamines on the reduction of hexavalent chromium by bacterial strains and their resistance. Polyamines are involved in several functions in bacteria.
Tahri Joutey, N., Sayel, H., Bahafid, W., El Ghachtouli, N.   +3 more
doaj  

A novel mechanism of resistance to α-difluoromethylornithine induced by cycloheximide Growth with abnormally low levels of putrescine and spermidine

, 1986
Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of α-difluoromethylornithine ...
Eduardo G.A. Cafferata, Estela E. Medrano, Algranati, Israel D., Medrano, Estela E., Israel D. Algranati, Oscar R. Burrone, Ferrer, Marcela M., Marcela M. Ferrer, Burrone, Oscar R., Cafferata, Eduardo G.A.   +9 more
core   +1 more source

Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.

PLoS ONE, 2013
Non-melanoma skin cancer (NMSC) is the most common type of skin cancer in Caucasian populations. Its increasing incidence has been a major public health concern.
Aadithya Arumugam, Zhiping Weng, Sarang S Talwelkar, Sandeep C Chaudhary, Levy Kopelovich, Craig A Elmets, Farrukh Afaq, Mohammad Athar   +7 more
doaj   +1 more source

Glucocorticoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells

Neoplasia: An International Journal for Oncology Research, 2002
Glucocorticoids are well-known apoptotic agents in certain classes of lymphoid cell malignancies. Reduction of intracellular polyamine levels by use of inhibitors that block polyamine synthesis slows or inhibits growth of many cells in vitro.
Aaron L. Miller, Betty H. Johnson, Rheem D. Medh, Courtney M. Townsend, E. Brad Thompson   +4 more
doaj   +1 more source

Topical Treatment with Diclofenac, Calcipotriol (Vitamin-D3 Analog) and Difluoromethylornithine (DFMO) Does Not Prevent Nonmelanoma Skin Cancer in Mice

, 2013
Nonmelanoma skin cancer is a common cancer type with increasing incidence. The purpose of this study was to evaluate topical application of diclofenac, calcipotriol, and difluoromethylornithine as chemoprevention in a mouse model of ultraviolet light ...
Burcharth, J, Raskov, H, Pommergaard, H C, Rosenberg, J   +3 more
core   +1 more source