Results 71 to 80 of about 3,296 (215)

Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin Cancer

, 2010
Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin ...
Ajit K. Verma (15095274), David Puchalsky (15095298), Paul P. Carbone (15095307), Theresa Lenaghan (15095283), Mary Hamielec (15095289), Thomas C. Havighurst (15095304), Nancy E. Dreckschmidt (15095286), Harry H. Sharata (15095295), Howard H. Bailey (15095271), Jeff Douglas (5116172), Eric R. Berg (15095301), Paul O. Larson (15095280), Jaye L. Viner (14977705), KyungMann Kim (6468221), Stephen Snow (9105590), Marcy Pomplun (15095292), Karen Sielaff (15095277)   +16 more
core   +1 more source

Characterization of alpha-difluoromethylornithine resistant Leishmania donovaniand its susceptibility to other inhibitors of the polyamine biosynthetic pathway

, 1996
The promastigote form ofLeishmania donovaniis sensitive to growth inhibition by DL -α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, exhibiting an IC50of 125µM.
Madhubala, R., Kapoor, Preeti, Mukhopadhyay, Rita   +2 more
core   +1 more source

Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas

, 2009
Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal ...
Christine E. McLaren (7924316), Eugene W. Gerner (14911290), Frank L. Meyskens (1307922), Daniel Pelot (15092031), Wen-Pin Chen (286916), Jason A. Zell (14975701)   +5 more
core   +1 more source

Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.

, 2009
Here we demonstrate a synergistic and tumor selective cytotoxic effect by combined treatment with naphthoxylosides, polyamine synthesis inhibitor, and polyamine based nitric oxide (NO) donor, using in vitro human tumor models.
Fransson, Lars-Åke, Mani, Katrin, Ellervik, Ulf, Johnsson, Richard, Nilsson, Jakob, Cheng, Fang   +5 more
core   +2 more sources

Polyamine Transport Inhibitors: Design, Synthesis, and Combination Therapies with Difluoromethylornithine

, 2016
The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to target cancers with high polyamine requirements.
Aaron Muth (847529), Otto Phanstiel (1801117), Jennifer Julian Archer (1854262), Meenu Madan (1854259), Nicolette Ocampo (1854256), Luis Rodriguez (341155)   +5 more
core   +2 more sources

Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant. [PDF]

PLoS ONE, 2013
The acquired mutation (V617F) of Janus kinase 2 (JAK2) is observed in the majority of patients with myeloproliferative neoplasms (MPNs). In the screening of genes whose expression was induced by JAK2 (V617F), we found the significant induction of c-Myc ...
Megumi Funakoshi-Tago, Kazuya Sumi, Tadashi Kasahara, Kenji Tago   +3 more
doaj   +1 more source

Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine [PDF]

Biochemical Journal, 2003
Racemic difluoromethylornithine (d/l-DFMO) is an inhibitor of ODC (ornithine decarboxylase), the first enzyme in eukaryotic polyamine biosynthesis. d/l-DFMO is an effective anti-parasitic agent and inhibitor of mammalian cell growth and development. Purified human ODC-catalysed ornithine decarboxylation is highly stereospecific.
Ning, Qu, Natalia A, Ignatenko, Phillip, Yamauchi, David E, Stringer, Corey, Levenson, Patrick, Shannon, Scott, Perrin, Eugene W, Gerner   +7 more
openaire   +2 more sources

Insight into the functional and structural relationship of ornithine decarboxylase and its mutants from Lacticaseibacillus rhamnosus

Bulletin of the Korean Chemical Society, Volume 46, Issue 7, Page 730-742, July 2025.
Structural and functional analysis of Lactaseibacillus rhamnosus ODC highlights a key residue influencing PLP binding, enzymatic activity, and crystal structure, providing insight into its catalytic mechanism. Abstract Ornithine decarboxylase (ODC) is a critical enzyme in the polyamine biosynthesis pathway that catalyzes the conversion of l‐ornithine ...
Nonvide Nicolas Adiko, Hyeon Tae Seo, Dae‐Won Ki, Jung Hee Park, Da Som Kim   +4 more
wiley   +1 more source

Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal Adenomas

, 2008
Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal ...
Christine E. McLaren (7924316), Sharon Fujikawa-Brooks (15092034), Eugene W. Gerner (14911290), Frank L. Meyskens (1307922), Daniel Pelot (15092031), Wen-Pin Chen (286916), Daniel L. Gillen (11083848)   +6 more
core   +1 more source

Isolation, propagation and characterization of "Trypanosoma brucei gambiense" from human African trypanosomosis patients in south Sudan [PDF]

, 2006
Sleeping sickness or Human African trypanosomosis (HAT) is a protozoal disease that is transmitted by tsetse fly vectors in Africa. Sleeping sickness due to T. b.
Maina, Naomi Wangari Njogu
core   +1 more source