Results 51 to 60 of about 3,859 (214)

Novel Water‐Soluble, Heavy Atom‐Free Thioxanthene‐Fused Naphthalimide–Polyamine Phototheranostic Conjugates

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Water‐soluble, heavy‐atom‐free naphthalimide–polyamine conjugates were developed as novel phototheranostic agents. Conjugates 2 and 3 showed effective photocytotoxicity in MCF‐7 cells with negligible dark toxicity. Fluorescence imaging confirmed efficient cellular uptake.
Elisa Uliassi, Michele Rossi, Matteo Di Giosia, Amalia Conti, Matteo Calvaresi, Kerry J. Rhoden, Maria Laura Bolognesi   +6 more
wiley   +1 more source

The effect of putrescine and difluoromethylornithine on cell division activity of wheat in different ploidy level

, 2005
Effects of exogenous putrescine (Put) and difluoromethylornithine (DFMO) on seed germination, root growth, mitotic activity and mitotic chromosome behavior were investigated in Triticum monococcum (2x), Triticum durum (4x) and Triticum aestivum (6x). Put

core   +1 more source

Microbiota–Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma

Brain and Behavior, Volume 16, Issue 8, August 2026.
Microbiota–neuroinflammation crosstalk in GBM. The schematic summarizes how gut microbiota and microbiota‐derived signals may influence GBM biology through gut–brain signaling, microbial metabolites, systemic immune modulation, BBB‐related pathways, tumor‐associated microbial signals, and immune‐metabolic changes within the GBM microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi S, Priya Priyadarshini Nayak, Anima Nanda, Shaker Al Hasnaawei, Akanksha Bhatt, Ashish Singh Chauhan, Siya Singla, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

Interaction Among Microbiota, Chemical Composition, and Quality Variations in Coffea arabica Across Altitudinal Gradients During Wet Processing

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Fermentation significantly altered the dominant bacterial genera from Sphingomonas and Pleomorphomonas (before fermentation) to Weissella and Lactobacillus (after fermentation), while Cladosporium and Fusarium remained the dominant fungal genera. Notably, non‐volatile compounds in de‐pulping coffee beans and volatile compounds of roasted coffee beans ...
Xiaojing Shen, Yamei Wu, Qi Wang, Wenhua Chen, Bintao Peng, Surui Lu, Ying Yang, Kunyi Liu, Jilai Zhang   +8 more
wiley   +1 more source

Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine

, 1989
Several bipyridinium, tetrapyridinium and hexapyridinium quaternary salts have been found to be potent inhibitors of putrescine uptake into B16 melanoma cells which had previously been treated with difluoromethylornithine.
Minchin, R. F., Ilett, K. F., Martin, R. L., Summers, L. A.   +3 more
core   +1 more source

A pilot study of genomic‐guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high‐risk neuroblastoma

Cancer Reports, 2022
Background Survival for patients with high‐risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapies. Aims To study the feasibility and safety of incorporating a genomic‐based targeted agent to induction therapy for HRNB as well as ...
Jacqueline M. Kraveka, Elizabeth C. Lewis, Genevieve Bergendahl, William Ferguson, Javier Oesterheld, Elizabeth Kim, Abhinav B. Nagulapally, Karl J. Dykema, Valerie I. Brown, William D. Roberts, Deanna Mitchell, Don Eslin, Derek Hanson, Michael S. Isakoff, Randal K. Wada, Virginia L. Harrod, Jawhar Rawwas, Gina Hanna, William P. D. Hendricks, Sara A. Byron, Matija Snuderl, Jonathan Serrano, Jeffrey M. Trent, Giselle L. Saulnier Sholler   +23 more
doaj   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Effect of alpha-difluoromethylornithine (DFMO) on the behavioral syndrome induced by intracerebroventricular injection of ACTH 1-24, in rats.

, 1984
Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (
BERNARDI, Mara, BERTOLINI, Alfio, GENEDANI, Susanna   +2 more
core   +1 more source

Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate

, 2009
Here we demonstrate a synergistic and tumor selective cytotoxic effect by combined treatment with naphthoxylosides, polyamine synthesis inhibitor, and polyamine based nitric oxide (NO) donor, using in vitro human tumor models.
Nilsson, Jakob,, Ellervik, Ulf,, Mani, Katrin,, Johnsson, Richard,, Lund University., Cheng, Fang,, Fransson, Lars-Åke,   +6 more
core   +2 more sources

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source