Results 51 to 60 of about 3,296 (215)

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, Volume 15, Issue 4, April 2026.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Supplementary Figure S4 from Unbiased Metabolite Profiling Indicates That a Diminished Thymidine Pool Is the Underlying Mechanism of Colon Cancer Chemoprevention by Alpha-Difluoromethylornithine

, 2013
Supplementary Figure S4 - PDF file 23K, Fig S4. DFMO Normal Human Colon Tissue. Normal human colon tissues were treated with DFMO(300nM) for 4 days. After treatment metabolites were extracted and analyzed by LC MS/MS.
Qiuying Chen (157606), Mavee Witherspoon (14893746), Steven M. Lipkin (14873730), Steven S. Gross (157625), Levy Kopelovich (32912)   +4 more
core   +1 more source

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

npj Precision Oncology, 2017
Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He, Eunmiri Roh, Ke Yao, Kangdong Liu, Xing Meng, Fangfang Liu, Penglei Wang, Ann M. Bode, Zigang Dong   +8 more
doaj   +1 more source

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

Frontiers in Cellular and Infection Microbiology, 2019
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Kami Kim, Louis M. Weiss, Louis M. Weiss   +11 more
doaj   +1 more source

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma, Ting Pan, Shengli Sun, Musitapa Mutalifu, Wei Yang, Yue Niu, Peng Chen   +6 more
wiley   +1 more source

Supplementary Figure Legends from Unbiased Metabolite Profiling Indicates That a Diminished Thymidine Pool Is the Underlying Mechanism of Colon Cancer Chemoprevention by Alpha-Difluoromethylornithine

, 2013
Supplementary Figure Legends - PDF file 30K, Supplementary Figure ...
Qiuying Chen (157606), Mavee Witherspoon (14893746), Steven M. Lipkin (14873730), Steven S. Gross (157625), Levy Kopelovich (32912)   +4 more
core   +1 more source

Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster

Medical Sciences, 2022
Polyamines are small organic cations that are essential for many biological processes such as cell proliferation and cell cycle progression. While the metabolism of polyamines has been well studied, the mechanisms by which polyamines are transported into
Coryn L. Stump, Robert A. Casero, Otto Phanstiel, Justin R. DiAngelo, Shannon L. Nowotarski   +4 more
doaj   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Perspective from Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

, 2008
Perspective from Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind ...
John McCracken (382841), Christine E. McLaren (7924316), Frank L. Meyskens (1307922), Steven Goldschmid (15092046), Daniel L. Gillen (11083848), D. Kim Turgeon (15092043), C. Gregory Albers (15092040), Sharon Fujikawa-Brooks (15092034), Eugene W. Gerner (14911290), Michael J. Lawson (12060308), Dennis J. Ahnen (11681805), Daniel Pelot (15092031), Jayashri Kidao (15092037), Gary Kelloff (15026490), Peter Lance (198534), Philip M. Carpenter (14925377), Ernest Hawk (7114970), Curt H. Hagedorn (15092049)   +17 more
core   +1 more source