Results 41 to 50 of about 3,296 (215)

Polyamines are present in mast cell secretory granules and are important for granule homeostasis. [PDF]

PLoS ONE, 2010
Mast cell secretory granules accommodate a large number of components, many of which interact with highly sulfated serglycin proteoglycan (PG) present within the granules.
Gianni García-Faroldi, Carlos E Rodríguez, José L Urdiales, José M Pérez-Pomares, José C Dávila, Gunnar Pejler, Francisca Sánchez-Jiménez, Ignacio Fajardo   +7 more
doaj   +1 more source

Supplementary Figure 1 from Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice

, 2011
Supplementary Figure 1 from Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in ...
Gang Xie (162461), Gerardo G. Mackenzie (11493781), Nengtai Ouyang (148972), Yu Sun (18463), Liqun Huang (409179), Kvetoslava Vrankova (409181), Levy Kopelovich (32912), Despina Komninou (14906283), Basil Rigas (148993)   +8 more
core   +1 more source

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Chemoprevention of Prostate Cancer with the Polyamine Synthesis Inhibitor Difluoromethylornithine [PDF]

, 2014
In vitro and in vivo preclinical results suggest that inhibition of polyamine synthesis inhibits the progression of prostate cancer.
Simoneau, AR, Meyskens, Frank L, Jr, Meyskens, FL, Gerner, Eugene W, Frank L. Meyskens, Simoneau, Anne R, Eugene W. Gerner, Gerner, EW, Anne R. Simoneau   +8 more
core   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Supplementary Figure S3 from Unbiased Metabolite Profiling Indicates That a Diminished Thymidine Pool Is the Underlying Mechanism of Colon Cancer Chemoprevention by Alpha-Difluoromethylornithine

, 2013
Supplementary Figure S3 - PDF file 234K, Fig.S3. Untargeted Metabolite Profiling of DFMO Treated ApcMin Mouse Tumors. Metabolite profiling identified differentially-expressed metabolites in DFMO-treated ApcMin mouse tumors, compared to tumors from ...
Qiuying Chen (157606), Mavee Witherspoon (14893746), Steven M. Lipkin (14873730), Steven S. Gross (157625), Levy Kopelovich (32912)   +4 more
core   +1 more source

A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression

Molecular Carcinogenesis, Volume 65, Issue 4, Page 508-522, April 2026.
ABSTRACT Prostate cancer (PCa) is the second most common cancer and second leading cause of cancer death for American men. Chemoprevention by using phytochemicals offers a promising approach to improve outcomes due to their ability to act on cancer cell metabolism and growth while maintaining low toxicity profiles.
Rachel Clark, Achinto Saha, G. Lavender Hackman, Chelsea A. Friedman, Ruggiero Gorgoglione, Stefano Tiziani, John DiGiovanni   +6 more
wiley   +1 more source

Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda.

, 2006
OBJECTIVES: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
Louga, Albino, Fogg Carole, Louga Albino, Ghabri, S, Piola, P, Piola, Patrice, Balasegaram, M, Checchi Francesco, Balasegaram, Manica, Priotto Gerardo, Louga, A, Checchi, F, Priotto, Gerardo, Priotto, G, Erphas, Olema, Checchi, Francesco, Ghabri, Salah, Erphas, O, Balasegaram Manica, Ghabri Salah, Erphas Olema, Fogg, C, Fogg, Carole, Piola Patrice   +23 more
core   +1 more source

Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation

Animal Nutrition, 2020
l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal epithelial cells.
Jing Wang, Bi'e Tan, Jianjun Li, Xiangfeng Kong, Minjie Tan, Guoyao Wu   +5 more
doaj   +1 more source

Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

Biomedicines, 2023
GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander, Erin Fahey, Otto Phanstiel, Susan K. Gilmour   +3 more
doaj   +1 more source