Results 41 to 50 of about 3,859 (214)

Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal Adenomas

, 2008
Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal ...
Christine E. McLaren (7924316), Sharon Fujikawa-Brooks (15092034), Eugene W. Gerner (14911290), Frank L. Meyskens (1307922), Daniel Pelot (15092031), Wen-Pin Chen (286916), Daniel L. Gillen (11083848)   +6 more
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, Volume 13, Issue 61, 3 November 2026.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas

, 2009
Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal ...
Christine E. McLaren (7924316), Eugene W. Gerner (14911290), Frank L. Meyskens (1307922), Daniel Pelot (15092031), Wen-Pin Chen (286916), Jason A. Zell (14975701)   +5 more
core   +1 more source

Functional Characterization of the P‐Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
ATP13A3 and ATP13A4 mediate the plasma membrane uptake of the polyamines, putrescine and spermidine, in an ATP‐dependent manner. ATP13A3 is broadly expressed across human tissues, whereas ATP13A4 is expressed at relatively high levels in the brain and lung.
Haruka Morimoto, Tomoya Yasujima, Mione Yamasaki, Takahiro Yamashiro, Hiroaki Yuasa   +4 more
wiley   +1 more source

Characterization of alpha-difluoromethylornithine resistant Leishmania donovaniand its susceptibility to other inhibitors of the polyamine biosynthetic pathway

, 1996
The promastigote form ofLeishmania donovaniis sensitive to growth inhibition by DL -α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, exhibiting an IC50of 125µM.
Madhubala, R., Kapoor, Preeti, Mukhopadhyay, Rita   +2 more
core   +1 more source

Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation

Animal Nutrition, 2020
l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal epithelial cells.
Jing Wang, Bi'e Tan, Jianjun Li, Xiangfeng Kong, Minjie Tan, Guoyao Wu   +5 more
doaj   +1 more source

Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

Biomedicines, 2023
GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander, Erin Fahey, Otto Phanstiel, Susan K. Gilmour   +3 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

Frontiers in Cellular and Infection Microbiology, 2019
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Kami Kim, Louis M. Weiss, Louis M. Weiss   +11 more
doaj   +1 more source

Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster

Medical Sciences, 2022
Polyamines are small organic cations that are essential for many biological processes such as cell proliferation and cell cycle progression. While the metabolism of polyamines has been well studied, the mechanisms by which polyamines are transported into
Coryn L. Stump, Robert A. Casero, Otto Phanstiel, Justin R. DiAngelo, Shannon L. Nowotarski   +4 more
doaj   +1 more source