Results 31 to 40 of about 3,859 (214)

Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy.
Yan Lin, Xiaojie Zhang, Wei Xiao, Bo Li, Jun Wang, Li Jin, Jie Lian, Li Zhou, Jicheng Liu   +8 more
doaj   +1 more source

Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma

Cancer Nanotechnology, 2023
Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) and vascular aberrations in the TME ...
Hongsheng Wang, Xinmeng Jin, Yinghua Gao, Xin He, Yiming Xu, Haoran Mu, Yafei Jiang, Zhuoying Wang, Chen Yu, Tao Zhang, Yingqi Hua, Zhengdong Cai, Jing Xu, Xiaojun Ma, Wei Sun   +14 more
doaj   +1 more source

A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors

Medical Sciences, 2018
Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid anti-tumor responses in the majority of patients with mutant BRAF melanoma, the tumors inevitably ...
Molly C. Peters, Allyson Minton, Otto Phanstiel IV, Susan K. Gilmour   +3 more
doaj   +1 more source

Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels

Frontiers in Cellular and Infection Microbiology, 2020
Current treatments of hepatitis B virus (HBV) are limited to Interferon-alpha or the nucleos(t)ide analogs antiviral therapies, and it is crucial to develop and define new antiviral drugs to cure HBV.
Binli Mao, Zhuo Wang, Sidie Pi, Quanxin Long, Ke Chen, Jing Cui, Ailong Huang, Yuan Hu   +7 more
doaj   +1 more source

Supplementary Figure 1 from Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice

, 2011
Supplementary Figure 1 from Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in ...
Gang Xie (162461), Gerardo G. Mackenzie (11493781), Nengtai Ouyang (148972), Yu Sun (18463), Liqun Huang (409179), Kvetoslava Vrankova (409181), Levy Kopelovich (32912), Despina Komninou (14906283), Basil Rigas (148993)   +8 more
core   +1 more source

Polyamines and related signaling pathways in cancer

Cancer Cell International, 2020
Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine.
Jiajing Li, Yan Meng, Xiaolin Wu, Yuxin Sun   +3 more
doaj   +1 more source

Polyamines are present in mast cell secretory granules and are important for granule homeostasis. [PDF]

PLoS ONE, 2010
Mast cell secretory granules accommodate a large number of components, many of which interact with highly sulfated serglycin proteoglycan (PG) present within the granules.
Gianni García-Faroldi, Carlos E Rodríguez, José L Urdiales, José M Pérez-Pomares, José C Dávila, Gunnar Pejler, Francisca Sánchez-Jiménez, Ignacio Fajardo   +7 more
doaj   +1 more source

Perspective from Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

, 2008
Perspective from Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind ...
John McCracken (382841), Christine E. McLaren (7924316), Frank L. Meyskens (1307922), Steven Goldschmid (15092046), Daniel L. Gillen (11083848), D. Kim Turgeon (15092043), C. Gregory Albers (15092040), Sharon Fujikawa-Brooks (15092034), Eugene W. Gerner (14911290), Michael J. Lawson (12060308), Dennis J. Ahnen (11681805), Daniel Pelot (15092031), Jayashri Kidao (15092037), Gary Kelloff (15026490), Peter Lance (198534), Philip M. Carpenter (14925377), Ernest Hawk (7114970), Curt H. Hagedorn (15092049)   +17 more
core   +1 more source

Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin Cancer

, 2010
Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin ...
Ajit K. Verma (15095274), David Puchalsky (15095298), Paul P. Carbone (15095307), Theresa Lenaghan (15095283), Mary Hamielec (15095289), Thomas C. Havighurst (15095304), Nancy E. Dreckschmidt (15095286), Harry H. Sharata (15095295), Howard H. Bailey (15095271), Jeff Douglas (5116172), Eric R. Berg (15095301), Paul O. Larson (15095280), Jaye L. Viner (14977705), KyungMann Kim (6468221), Stephen Snow (9105590), Marcy Pomplun (15095292), Karen Sielaff (15095277)   +16 more
core   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source