Results 31 to 40 of about 3,296 (215)

The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. [PDF]

PLoS ONE, 2012
Exposure to uncontrolled irradiation in a radiologic terrorism scenario, a natural disaster or a nuclear battlefield, will likely be concomitantly superimposed on other types of injury, such as trauma.
Susanna Rosi, Ryan Ferguson, Kelly Fishman, Antino Allen, Jacob Raber, John R Fike   +5 more
doaj   +1 more source

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. [PDF]

PLoS ONE, 2011
Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ...
Daniel P Barry, Mohammad Asim, David A Leiman, Thibaut de Sablet, Kshipra Singh, Robert A Casero, Rupesh Chaturvedi, Keith T Wilson   +7 more
doaj   +1 more source

Activité thérapeutique et prophylactique de la combinaison Berenil^R et DL-alpha-difluorométhylornithine (DFMO^R) contre l’infection à Trypanosoma brucei brucei chez la souris

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1991
Les auteurs ont étudié l'activité théapeutique et prophylactique de l'association DL-alpha-difluorométhylornithine (à la dose de 2 % dans l'eau de boisson) et BerenilR (à 7 mg par kg de poids vif par voie intrapéritonéale) sur des souris infectées par ...
P.A. Onyeyili, G.O. Egwu, L.T. Zaria, B.A. Orjiude   +3 more
doaj   +1 more source

Decarboxylation of α-difluoromethylornithine by ornithine decarboxylase [PDF]

Biochemical Journal, 1987
The mechanism of inactivation of rodent ornithine decarboxylase by alpha-difluoromethylornithine (DFMO) was studied using the inhibitor labelled with 14C in both the 1 and the 5 positions. [1-14C]DFMO was a substrate and was decarboxylated by the enzyme yielding 14CO2.
A E, Pegg, K A, McGovern, L, Wiest
openaire   +2 more sources

Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy.
Yan Lin, Xiaojie Zhang, Wei Xiao, Bo Li, Jun Wang, Li Jin, Jie Lian, Li Zhou, Jicheng Liu   +8 more
doaj   +1 more source

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei [PDF]

, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Burgess, K., Burchmore, Richard J S, Barrett, M.P., Creek, D.J., Vincent, I.M., Woods, Debra, Karl Burgess, Richard J S Burchmore, Woods, Debra J, Creek, Darren, Debra J. Woods (167740), Creek, Darren John, Isabel M Vincent, Vincent, Isabel M, Michael P Barrett, Darren J. Creek (167726), Woods, D.J., Isabel M. Vincent (167717), Woods Debra J., Burgess Karl, Burgess, Karl, Burchmore, Richard, Barrett, Michael P, Vincent, Isabel, Barrett Michael P., Burchmore, R.J.S., Creek Darren J., Richard J. S. Burchmore (167742), Vincent Isabel M., Darren J Creek, Karl Burgess (167732), Debra J Woods, Barrett, Michael, Michael P. Barrett (167748), Burchmore Richard J. S.   +34 more
core   +1 more source

Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma

Cancer Nanotechnology, 2023
Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) and vascular aberrations in the TME ...
Hongsheng Wang, Xinmeng Jin, Yinghua Gao, Xin He, Yiming Xu, Haoran Mu, Yafei Jiang, Zhuoying Wang, Chen Yu, Tao Zhang, Yingqi Hua, Zhengdong Cai, Jing Xu, Xiaojun Ma, Wei Sun   +14 more
doaj   +1 more source

A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors

Medical Sciences, 2018
Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid anti-tumor responses in the majority of patients with mutant BRAF melanoma, the tumors inevitably ...
Molly C. Peters, Allyson Minton, Otto Phanstiel IV, Susan K. Gilmour   +3 more
doaj   +1 more source

Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels

Frontiers in Cellular and Infection Microbiology, 2020
Current treatments of hepatitis B virus (HBV) are limited to Interferon-alpha or the nucleos(t)ide analogs antiviral therapies, and it is crucial to develop and define new antiviral drugs to cure HBV.
Binli Mao, Zhuo Wang, Sidie Pi, Quanxin Long, Ke Chen, Jing Cui, Ailong Huang, Yuan Hu   +7 more
doaj   +1 more source

Polyamines and related signaling pathways in cancer

Cancer Cell International, 2020
Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine.
Jiajing Li, Yan Meng, Xiaolin Wu, Yuxin Sun   +3 more
doaj   +1 more source