Results 21 to 30 of about 3,859 (214)
Testosterone as Diamine Oxidase Activity Regulator [PDF]
BioDiscovery, 2017 Diamine oxidase (DAO) is a key enzyme of the metabolism of polyamines. Its activity was assayed in homogenate of male immature rat liver and kidney. The androgens are important regulators of polyamines’ metabolism.
Milena Mishonova, Hristo Gagov
doaj +3 more sources
Biomolecules, 2021 Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen +4 more
doaj +1 more source
Biomolecules, 2020 We report the results of our in silico study of approved drugs as potential treatments for COVID-19. The study is based on the analysis of normal modes of proteins.
Ognjen Perišić
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The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. [PDF]
PLoS ONE, 2012 Exposure to uncontrolled irradiation in a radiologic terrorism scenario, a natural disaster or a nuclear battlefield, will likely be concomitantly superimposed on other types of injury, such as trauma.
Susanna Rosi +5 more
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Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers
Medical Sciences, 2017 Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro +2 more
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Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. [PDF]
PLoS ONE, 2011 Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ...
Daniel P Barry +7 more
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Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine. [PDF]
, 2014 In vitro and in vivo preclinical results suggest that inhibition of polyamine synthesis inhibits the progression of prostate cancer.
Meyskens, Frank L, Jr +2 more
core +3 more sources
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
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Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1991 Les auteurs ont étudié l'activité théapeutique et prophylactique de l'association DL-alpha-difluorométhylornithine (à la dose de 2 % dans l'eau de boisson) et BerenilR (à 7 mg par kg de poids vif par voie intrapéritonéale) sur des souris infectées par ...
P.A. Onyeyili +3 more
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Decarboxylation of α-difluoromethylornithine by ornithine decarboxylase [PDF]
Biochemical Journal, 1987 The mechanism of inactivation of rodent ornithine decarboxylase by alpha-difluoromethylornithine (DFMO) was studied using the inhibitor labelled with 14C in both the 1 and the 5 positions. [1-14C]DFMO was a substrate and was decarboxylated by the enzyme yielding 14CO2.
A E, Pegg, K A, McGovern, L, Wiest
openaire +2 more sources