Results 21 to 30 of about 3,296 (215)

In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation [PDF]

Amino Acids
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme ornithine decarboxylase (ODC) of polyamine biosynthesis, α-difluoromethylornithine (DFMO), are implicated ...
Chien-Ching Lee, Chia-Chun Chuang, Chung-Hwan Chen, Yuan-Pin Huang, Chiao-Yi Chang, Pei-Yi Tung, Mon-Juan Lee   +6 more
doaj   +2 more sources

Development of difluoromethylornithine (DFMO) as a chemoprevention agent. [PDF]

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
D,L-alpha-difluoromethylornithine (DFMO) was synthesized over 20 years ago. It was hoped that this enzyme-activated, irreversible inhibitor of ornithine decarboxylase, the first enzyme in polyamine synthesis, would be effective as a chemotherapy for hyperproliferative diseases, including cancer and/or infectious processes.
Meyskens, F L, Jr, Gerner, E W
openaire   +3 more sources

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park, Suyeon Yellena Kim, C. Justin Lee   +2 more
doaj   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek Darren, Watson David G., Burchmore, Richard J S, Barrett, M.P., Michael P. Barrett, Woods, DJ, Pui Ee Wong, Vincent, I.M., Darren Creek, Vincent, IM, Kamleh, M.A., Richard J S Burchmore, Wong, P.E., Kamleh, Mohammed A, Woods, Debra J, Creek, Darren, Richard J. S. Burchmore, Wong, PE, Vincent, Isabel M, Isabel M Vincent, Michael P Barrett, Isabel M. Vincent, Kamleh, MA, Watson, DG, Woods, D.J., Wong, Pui Ee, Woods Debra J., Mohammed A. Kamleh, David G. Watson, Barrett, Michael P, Creek, D., Barrett Michael P., Barrett, MP, Burchmore, R.J.S., Wong Pui Ee, David G Watson, Kamleh Mohammed A., Vincent Isabel M., Watson, David G, Burchmore, RJS, Creek, D, Watson, D.G., Debra J Woods, Debra J. Woods, Mohammed A Kamleh, Burchmore Richard J. S.   +45 more
core   +1 more source

Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein–Drug and Protein–Protein Structures: An Analysis of Kinetically Active Residues

Biomolecules, 2020
We report the results of our in silico study of approved drugs as potential treatments for COVID-19. The study is based on the analysis of normal modes of proteins.
Ognjen Perišić
doaj   +1 more source

Testosterone as Diamine Oxidase Activity Regulator [PDF]

BioDiscovery, 2017
Diamine oxidase (DAO) is a key enzyme of the metabolism of polyamines. Its activity was assayed in homogenate of male immature rat liver and kidney.  The androgens are important regulators of polyamines’ metabolism.
Milena Mishonova, Hristo Gagov
doaj   +3 more sources

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
doaj   +1 more source

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

Medical Sciences, 2018
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts   +4 more
doaj   +1 more source

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Medical Sciences, 2017
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro, Jenna Thomas, Otto Phanstiel   +2 more
doaj   +1 more source

Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice

Pulmonary Circulation, 2020
Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer, M. Turzo, F. Lasitschka, M.A. Weigand, C.J. Busch   +4 more
doaj   +1 more source