Results 11 to 20 of about 3,296 (215)

Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations [PDF]

Beilstein Journal of Organic Chemistry
Difluoromethylornithine (DFMO, eflornithine) is a fluorinated analogue of ornithine that serves both as an inhibitor of ornithine decarboxylase and as a therapeutic agent against African trypanosomiasis.
Matheus P. Freitas
doaj   +2 more sources

New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on Trypanosoma cruzi in vitro and in vivo [PDF]

Frontiers in Cellular and Infection Microbiology
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is currently a global health problem. Its multiple forms of transmission, which favor the spread of the infection, and the limited treatment options—still restricted to only two drugs ...
Santiago José Martínez, Santiago José Martínez, María Cristina Vanrell, María Cristina Vanrell, Xiaomo Li, Carolina Carrillo, David M. Engman, Patricia Silvia Romano, Patricia Silvia Romano   +8 more
doaj   +2 more sources

Dose-Related α-Difluoromethylornithine Ototoxicity [PDF]

American Journal of Clinical Oncology, 1991
We assessed the ototoxicity associated with oral alpha-difluoromethylornithine (DFMO) administration in 58 patients with metastatic malignant melanoma. One hundred seventy-nine sequential audiograms obtained from patients treated with DFMO alone (16 patients) or in combination with alpha 2b-interferon (42 patients) were evaluated.
Croghan, Marilyn K, Aickin, Mikel G, Meyskens, Frank L   +2 more
openaire   +6 more sources

Correction to "The polyamine transporter ATP13A3 mediates difluoromethylornithine-induced polyamine uptake in neuroblastoma". [PDF]

Mol Oncol
Molecular Oncology, Volume 19, Issue 8, Page 2457-2457, August 2025.
europepmc   +2 more sources

The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma [PDF]

Molecular Oncology
High‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning.
Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers   +19 more
doaj   +2 more sources

Repurposing With Purpose: Treatment of Bachmann-Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies. [PDF]

Am J Med Genet C Semin Med Genet
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Bupp CP, VanSickle EA, Michael J, Schultz CR, Nguyen K, Hoefer M, Rajasekaran S, Bachmann AS.   +7 more
europepmc   +2 more sources

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas

CNS Oncology, 2018
This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin, Sandra E Ictech, Kenneth R Hess   +2 more
doaj   +2 more sources

Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection [PDF]

Viruses
Despite numerous research efforts and several effective vaccines and therapies developed against coronavirus disease 2019 (COVID-19), drug repurposing remains an attractive alternative approach for treatment of SARS-CoV-2 variants and other viral ...
Natalia A. Ignatenko, Hien T. Trinh, April M. Wagner, Eugene W. Gerner, Christian Bime, Chiu-Hsieh Hsu, David G. Besselsen   +6 more
doaj   +2 more sources

ODC-Driven Polyamines Synthesis Sustains the Self-Renewal of Glioblastoma Stem Cells and Drives Tumor Aggressiveness. [PDF]

Cancer Sci
Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Wei XC, Zhang HQ, Liu GQ, Liu CW, Li AL, Pan X, Yan WQ, Chen JY.   +7 more
europepmc   +2 more sources

Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae [PDF]

Biomolecules
Streptococcus pneumoniae (Spn), a Gram-positive bacterium, poses a significant threat to human health, causing mild respiratory infections to severe invasive conditions. Despite the availability of vaccines, challenges persist due to serotype replacement
Moses B. Ayoola, Leslie A. Shack, Otto Phanstiel, Bindu Nanduri   +3 more
doaj   +2 more sources