Results 81 to 90 of about 3,859 (214)

Induction Regimens in High‐Risk Neuroblastoma: Systematic Review of Response Rates and Toxicities

Cancer Medicine, Volume 14, Issue 22, November 2025.
ABSTRACT Background Numerous induction therapies have been evaluated for high‐risk neuroblastoma (HRNBL). It is not known how these regimens' response rates nor toxicities compare. We aimed to describe and compare key features of HRNBL induction regimens and their associations with study‐level end‐induction response (EIR).
Samantha D. Martin, Eva C. Robinson, Edie Weller, Rochelle Bagatell, Lucas Moreno, Steven G. DuBois   +5 more
wiley   +1 more source

Difluoromethylornithine prevents the down-regulation of type 1 interferon receptors: A possible mechanism for a synergistic antiproliferative effect

, 1990
Type I interferon and difluoromethylornithine have been shown to exert an antiproliferative effect, both alone and in combination, in several tumor cell lines.
Lai, M. C., Minchin, R. F., Dilollo, D. L., Beilharz, M. W.   +3 more
core  

Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II

Cellular Physiology and Biochemistry, 2016
Background/Aims: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the overall survival has remained relatively unchanged for over two decades.
Bhuvana A. Setty, Yi Jin, Peter J. Houghton, Nicholas D. Yeager, Thomas G. Gross, Leif D. Nelin   +5 more
doaj   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Isolation and characterization of human breast adenocarcinoma cells made resistant to α-difluoromethylornithine

, 2000
Human breast adenocarcinoma cells MCF-7 were selected for resistance to ornithine decarboxylase (ODC) inhibitor, α-difluoromethylornithine (DFMO). Stepwise increments of the concentration of DFMO resulted in selection of MCF-7 cells that were capable of ...
Khurana, Kamal K., Das, Bhagwan, Vig, Monika, Madhubala, Rentala   +3 more
core   +1 more source

Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function

Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO).
Juan Pablo Arnoletti (12275290), Otto Phanstiel (1801117), Holly Moots (8519748), Sharifa Dinara (8519742), Kunal Shah (5999576), Paul M. Hershberger (1545562), Aiste Dobrovolskaite (11979807), David Levens (138737), Chelsea Massaro (8519733), Jenna Thomas (8519736), Eliot Sugarman (1346577), Patrick R. Maloney (1912969), Satyamaheshwar Peddibhotla (1271367), Rajiv Kumar Jha (3993509), Sally Litherland (14127867), Mukund P. Tantak (14127864)   +15 more
core   +5 more sources

Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
doaj   +1 more source

Α-Difluoromethylornithine (DFMO) delays orthotopic tumor growth of MDA-MB-231 cells

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

Effet des polyamines sur la réduction du chrome hexavalent par des souches bactériennes et leur résistance

Biotechnologie, Agronomie, Société et Environnement, 2014
Effect of polyamines on the reduction of hexavalent chromium by bacterial strains and their resistance. Polyamines are involved in several functions in bacteria.
Tahri Joutey, N., Sayel, H., Bahafid, W., El Ghachtouli, N.   +3 more
doaj  

Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae

Biomolecules
Streptococcus pneumoniae (Spn), a Gram-positive bacterium, poses a significant threat to human health, causing mild respiratory infections to severe invasive conditions. Despite the availability of vaccines, challenges persist due to serotype replacement
Moses B. Ayoola, Leslie A. Shack, Otto Phanstiel, Bindu Nanduri   +3 more
doaj   +1 more source