Results 111 to 120 of about 3,296 (215)

Effect of alpha-difluoromethylornithine (DFMO) on the behavioral syndrome induced by intracerebroventricular injection of ACTH 1-24, in rats.

, 1984
Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (
BERNARDI, Mara, BERTOLINI, Alfio, GENEDANI, Susanna   +2 more
core  

Chemopreventionof long-term oncological consequences on the model of radiation carcinogenesis in female rats

Сибирский онкологический журнал, 2016
A comparative study of the anticarcinogenic activity of synthetic polyamine inhibitor α-difluoromethylornithine (DFMO) and three plant drugs on the model of radiation carcinogenesis was carried out in 615 female Wistar rats subjected to total body γ ...
V. G. Bespalov, A. V. Alexandrov, A. L. Semenov, E. G. Kovanko, S. D. Ivanov   +4 more
doaj  

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Development of Adjunctive Agents for Difluoromethylornithine Anti-cancer Therapy

, 2021
The native polyamines putrescine, spermidine, and spermine are small positively-charged molecules that can interact with negatively-charged macromolecules like DNA, RNA and proteins.
Dobrovolskaite, Aiste
core  

Repurposing Clinically Relevant Metabolic Inhibitor Drugs, Difluoromethylornithine (DFMO) and Orlistat, for gammaherpesvirus Replication

Viruses, including herpesviruses, contribute up to 15% of all human cancers. Murine gammaherpesvirus-68 (MHV-68), a pathogen commonly found in mice, is studied due to its shared homology with several human herpesviruses.
Paw, Lay
core  

Induction of intestinal mucosal atrophy by difluoromethylornithine: a nonuremic model of enhanced aluminum absorption

, 1992
The intestinal absorption of aluminum (Al) appears to be enhanced in the uremic rat. Since atrophic changes of the intestinal mucosa have been observed in uremia the present study investigated whether intestinal atrophy induced by difluoromethylornithine
Ittel, T. H., Paulus, C. P., Sieberth, H. G., Hofstädter, Ferdinand, Handt, S.   +4 more
core  

Rebalancing polyamine levels to treat Snyder-Robinson syndrome. [PDF]

EMBO Mol Med, 2023
Gilmour SK.
europepmc   +1 more source

Effect of alpha-difluoromethylornithine on DNA methylation in murine erythroleukaemic cells. Relationship to stimulation of induced differentiation.

, 1987
International audienceMurine erythroleukaemic (MEL) cells cultured with alpha-difluoromethylornithine (DFMO) accumulated decarboxylated S-adenosylmethionine(decarboxylated AdoMet).
Osborne, Howard Beverley, Papazafiri, Panagiota   +1 more
core  

Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis. [PDF]

Neurosurgery, 2023
Riviere-Cazaux C, Neth BJ, Hoplin MD, Wessel B, Miska J, Kizilbash SH, Burns TC.   +6 more
europepmc   +1 more source

A direct fluorescence assay for quantitative analysis of ornithine decarboxylase activity and inhibitor screening. [PDF]

J Biol Chem
Choi JY, Bereta G, Furry M, Vanderwal CD, Grudnik P, Ben Mamoun C.   +5 more
europepmc   +1 more source