Results 51 to 60 of about 11,104 (231)
Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]
, 2014 Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía +5 more
core +3 more sources
Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts [PDF]
, 2006 Objectives: The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I,, in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5.
Banse, U. +8 more
core +1 more source
Cardiac Glycosides in Human Physiology and Disease: Update for Entomologists
Insects, 2019 Cardiac glycosides, cardenolides and bufadienolides, are elaborated by several plant or animal species to prevent grazing or predation. Entomologists have characterized several insect species that have evolved the ability to sequester these glycosides in
Rif S. El-Mallakh +2 more
doaj +1 more source
A case of alcaptonuria with fatal cardiovascular disturbance [PDF]
, 1976 A case of alcaptonuria combined with aortic insufficiency was found in a 28-year-old male. The patient was palpitating at admission. The daily excretion of homogentisic acid was 2.0-6.0 g.
Arima, Terukatsu +6 more
core +1 more source
Drugs - Real World Outcomes, 2023 Background Cardiac glycosides such as digoxin, digitoxin and ouabain are still used around the world to treat patients with chronic heart failure with reduced ejection fraction (HFrEF) and/or atrial fibrillation (AF).
Amanda L. Banaag +2 more
doaj +1 more source
Annals of the American Thoracic Society, 2017 Rationale: Cystic fibrosis (CF) lung disease progresses by a combination of airway inflammation, bacterial colonization, and infection. Airway inflammation is predominantly neutrophilic and complicates airway clearance therapies through cellular debris ...
P. Zeitlin +7 more
semanticscholar +1 more source
Small Methods, EarlyView.Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner +7 more
wiley +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Coevolutionary arms races between plants and insects, in which gains of novel plant defences select for counteradaptations in herbivores, are key drivers of biodiversity.
Broti Biswas +5 more
wiley +1 more source
Digoxin Inhibits Retinoblastoma through Suppressing a Non-canonical TGFβ Signaling Pathway. [PDF]
, 2016 Aims: Retinoblastoma is a childhood ocular tumor rapidly developing from the immature cells of the retina due to loss of functional retinoblastoma protein.
Akbari, Abolfazl. +8 more
core +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source