Tackling the Reactivity of Propadiene: Palladium Metallaphotoredox Dual Catalyzed Multi-Component Allylation and Dienylation of Styrenes. [PDF]
We presented herein that propadiene can chemodivergently form either an allylic moiety or a dienylic moiety under Pd catalysis. Embedding this reactivity pattern into photocatalysis with DHP as the initial radical source and styrene derivatives as the initial acceptor leads to multi‐component allylation and dienylation.
Yang YF, Bauer F, Breit B.
europepmc +3 more sources
Screening and Diagnosis of Primary Aldosteronism in Patients Using Renin-Angiotensin System Inhibitors. [PDF]
ABSTRACT This study investigated whether patients receiving renin‐angiotensin system inhibitors (RASIs) can undergo reliable screening for primary aldosteronism (PA) without discontinuation of therapy. Consecutive patients with hypertension who underwent PA screening at our hospital between 2016 and 2024 while on RASIs were recruited.
Wang Q, Dong H, Li HW, Zou YB, Jiang XJ.
europepmc +2 more sources
Diethyl 4-(3-chlorophenyl)-2,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylate
In the title compound, C29H26ClNO4, the dihydropyridine ring adopts a shallow boat conformation. The mean plane of the dihydropyridine ring (all atoms) subtends dihedral angles of 66.54 (1), 73.71 (1) and 79.47 (1)° with the two phenyl rings and the ...
K. K. Mohammed Ameen +3 more
doaj +1 more source
MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]
The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
Bolton, TB +3 more
core +1 more source
An experiment was conducted to investigate the effects of dihydropyridine supplementation on growth performance and lipid metabolism of broilers. A total of 480 one-day-old female Arbor Acres broiler chicks were randomly divided into four groups, each ...
Z.Y. Niu, F.Z. Liu, Y.N. Min, W.C. Li
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We examined the effects of a dihydropyridine analog, PAK-200, on guinea pig myocardium during experimental ischemia and reperfusion. In isolated ventricular cardiomyocytes, PAK-200 (1 μM) had no effect on the basal peak inward and steady-state currents ...
Iyuki Namekata +4 more
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Photodegradation of nimodipine and felodipine in microheterogeneous systems [PDF]
Indexación: Web of Science; ScieloThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media.
Brito, Julio +6 more
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Recent Progresses in the Catalytic Stereoselective Dearomatization of Pyridines
1,2- and 1,4-dihydropyridines and N-substituted 2-pyridones are very important structural motifs due to their synthetic versatility and vast presence in a variety of alkaloids and bioactive molecules.
Lucrezia Margherita Comparini +1 more
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One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor [PDF]
The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann–Rahtz reaction, the use
Bagley, Mark C +4 more
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Immunochemical detection of a lipofuscin-like fluorophore derived from malondialdehyde and lysine
The accumulation of fluorescent age pigment or lipofuscin is a frequently observed age-associated cellular alteration in a variety of postmitotic cells of many species. These pigments are observed within granules composed, in part, of damaged protein and
Satoshi Yamada +9 more
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