The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity [PDF]
, 2005 Acid-sensing ion channels (ASICs) are ion channels activated by extracellular protons. They are involved in higher brain functions and perception of pain, taste, and mechanical stimuli.
Chen, Xuanmao
core +1 more source
Application of a new high performance liquid chromatography method to the pharmacokinetics of dibudipine in rats [PDF]
Purpose: To develop a HPLC method for assay of dibudipine in biological fluids and to study its pharmacokinetics in the rat. Methods. HPLC: 2 μl (20 μg/ml) mebudipine as internal standard, 0.2 ml NaOH 1 M and 2 ml ethyl acetate were added to 0.2 ml of ...
بهلولی, شهاب +3 more
core
Levels of Ca\u3csub\u3ev\u3c/sub\u3e1.2 L-Type Ca\u3csup\u3e2+\u3c/sup\u3e Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca\u3csub\u3ev\u3c/sub\u3e1.3 Channels Steadily Increase through Development [PDF]
, 2012 Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled ...
Ingraham, Nicholas E. +3 more
core +1 more source
Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure
PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong +14 more
wiley +1 more source
Opposite Effects of a Single IIIS5 Mutation on Phenylalkylamine and Dihydropyridine Interaction with L-type Ca2+ Channels [PDF]
, 2004 Irene Huber +5 more
openalex +1 more source
Pulmonary Circulation, Volume 16, Issue 1, January 2026.ABSTRACT Pulmonary hypertension (PH) causes progressive pulmonary vascular resistance and right heart failure. We investigated whether beta‐alanine (β‐Ala) improves right ventricular (RV) remodeling and dysfunction in a monocrotaline (MCT)‐induced PH rat model. Male Wistar rats were assigned to control, MCT‐PH, and β‐Ala‐treated PH groups.
Hongling Su +11 more
wiley +1 more source
Clinical Otolaryngology, Volume 51, Issue 1, Page 17-24, January 2026.ABSTRACT Objective Identify and summarise the evidence on the efficacy of low‐dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Methods Two reviewers independently searched the data sources until the 28th of December 2023.
Fangxing Yin +3 more
wiley +1 more source
Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2002 The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi +1 more
doaj
High doses of lercanidipine are better tolerated than other dihydropyridines in hypertensive patients with metabolic syndrome: results from the TOLERANCE study [PDF]
, 2008 Vivencio Barrios +6 more
openalex +1 more source
Addressing unmet needs for chronic kidney disease treatment in type 1 diabetes: A review
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 16-26, January 2026.Abstract Chronic kidney disease (CKD) is a serious complication occurring in nearly one of three people with type 1 diabetes (T1D). Major therapeutic advances have been made in the management of CKD for people with type 2 diabetes (T2D), thereby improving their kidney, cardiovascular, and survival outcomes.
Katherine R. Tuttle +3 more
wiley +1 more source