DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]
Chem BiodiversDES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G +10 more
europepmc +4 more sources
Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents. [PDF]
J Oncol, 2022 The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because of the high incidence and mortality rate of breast cancer, there is a dire need of discovering new pharmacotherapeutic agents in managing this disease.
Altaf R +8 more
europepmc +4 more sources
Bulletin of the Chemical Society of Ethiopia, 2017 The reactive intermediate generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates was trapped by N-formyl urea to produce highly functionalized dihydropyrimidinones in fairly good yields.
A. Naderi, B. Mohtat
doaj +3 more sources
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures [PDF]
Beilstein Journal of Organic Chemistry, 2022 A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported.
Sangram Gore +2 more
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Aryl-Substituted Dihydro-Pyrimidines Effecting Kinesin Eg5 as Novel Approach for Cancer Treatment [PDF]
MoleculesCancer is one of the most lethal diseases of this century. Unfortunately, many anticancer agents have harsh side effects or fail to work against cancer any longer due to tolerance.
Dialekti Chlorou, Eleni Pontiki
doaj +2 more sources
Journal of Saudi Chemical Society, 2023 Despite decades of research, anticancer medication therapy is still largely constrained to prevent growth and limit the spread of tumour cells.
M.K.M. Abdul Lathiff +5 more
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Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions. [PDF]
Pharmaceuticals (Basel), 2022 The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Sánchez-Sancho F +6 more
europepmc +3 more sources
Sustainable One-Pot Synthesis of Dihydropyrimidinones Using a Bio-Waste-Derived Magnetic Sulfonated SBA-16/NiAl-LDO Catalyst. [PDF]
ACS OmegaThis study presents the development of a novel magnetic heterogeneous catalyst derived from waste sugarcane bagasse ash for the efficient one-pot synthesis of dihydropyrimidinones via the Biginelli reaction. The catalyst combines mesoporous SBA-16 silica
Noppawan P +5 more
europepmc +2 more sources
H2SO4-Silica Catalyzed One-Pot and Efficient Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions [PDF]
E-Journal of Chemistry, 2011 H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields ...
Seied Ali Pourmousavi, Maryam Hasani
doaj +3 more sources
Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions [PDF]
E-Journal of Chemistry, 2011 In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one ...
Taoues Boumoud +3 more
doaj +2 more sources