Results 41 to 50 of about 392 (166)
Results in Chemistry, 2023 Breast cancer and gliobalstoma are the most aggressive types of diseases causing serious health issues. Potent anticancer molecules are facing serious side effects which arouse the need for newer molecules with significant clinical efficacy and safety ...
Dhirajkumar Nikam, Anurekha Jain
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Antibacterial Studies of Dihydropyrimidinones and Pyrimidinethiones [PDF]
Journal of Bacteriology & Mycology: Open Access, 2017 Some new dihydro pyrimidinone and pyrimidinethione compounds have been synthesized and their antibacterial activities have been studied in dimethyl formamide and dimethyl sulphoxide against some Gram positive and Gram negative bacteria For this Agar well diffusion method is used It is observed that inhibition depends on solvent bacterial strain ...
openaire +1 more source
An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System [PDF]
Journal of Sciences, Islamic Republic of Iran, 2014 An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green ...
B. Pouramiri +3 more
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New Anticancer 4‐Aryldihydropyrimidinone‐5‐Carboxylates Targeting Hsp90
Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Cinzia Bordoni +4 more
wiley +1 more source
Green Processing and Synthesis, 2017 Cobalt supported on alumina (10 wt% Co/Al2O3) was synthesized by three different methods; sol-gel (SG), microemulsion (ME) and impregnation (IMP). The materials were characterized by the Brunauer-Emmett-Teller (BET) method, X-ray diffraction (XRD), X-ray
Khiar Chahinaz +7 more
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Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar +8 more
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ChemistrySelect, Volume 10, Issue 38, October 13, 2025.Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK +3 more
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ChemMedChem, Volume 20, Issue 11, June 2, 2025.Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar +10 more
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Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors
ChemistrySelect, Volume 10, Issue 21, June 4, 2025.1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti +6 more
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ChemistrySelect, Volume 10, Issue 22, June 11, 2025.A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo +4 more
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