Results 21 to 30 of about 392 (166)

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative [PDF]

Frontiers in Pharmacology, 2021
Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen   +4 more
doaj   +2 more sources

O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization [PDF]

Beilstein Journal of Organic Chemistry
A one-pot three-component Biginelli synthesis of dihydropyrimidinones/thiones/selenones via acetic acid or solvent-free Yb(OTf)3-catalyzed tandem reaction of β-ketosulfone (dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide), an appropriate urea, and ...
Kateryna V. Dil, Vitalii A. Palchykov
doaj   +2 more sources

Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**

ChemMedChem, Volume 18, Issue 20, October 17, 2023., 2023
One quinazolin‐2,4,6‐triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin‐2,4,6‐triamine derivatives acted as superoxide scavengers, and one 5,6‐dihydro‐3H‐pirimidin‐4‐one showed bXO inhibitory activity ...
Marcela A. Lopez‐Sanchez, María del Carmen Garcia‐Rodriguez, Rodrigo Aguayo‐Ortiz, Estefani Hernandez‐Cruz, Diego I. Figueroa‐Figueroa, Francisco Hernandez‐Luis   +5 more
wiley   +1 more source

Methyl 6-Methyl-1-(4-methylphenyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2012
Methyl 6-methyl-1-(4-methylphenyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate has been synthesized via the modified Biginelli reaction from benzaldehyde, p-tolylurea, and methyl acetoacetate, promoted with microwave irradiation and ...
Haiping Wang, Qing Chen, Qingjian Liu
doaj   +1 more source

Microwave assisted Biginelli cyclocon densation for the synthesis of dihydropyrimidinones catalysed by H2SO4Clay NPs and their applications

Journal of Photochemistry and Photobiology, 2021
The Acid Modification of Bentonite clay (AMC) process was firstly reported and has been developed in one pot by ionic exchange of inorganic interlayer clay combined with different concentrations of acid (H2SO4) under Microwave irradiation.
B.S. Surendra, K. Shyam Prasad, T R Shashi Shekhar, A. A Jahagirdar, S C Prashantha, N. Raghavendra, K. Gurushantha, N. Basavaraju, K. Rudresha   +8 more
doaj   +1 more source

Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

Beilstein Journal of Organic Chemistry, 2013
A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and
Haijun Qu, Xuejian Li, Fan Mo, Xufeng Lin   +3 more
doaj   +1 more source

Sono-thermal oxidation of dihydropyrimidinones

Ultrasonics Sonochemistry, 2008
Combination of ultrasound and heat has been used for the oxidation of some ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates by using potassium peroxydisulfate in aqueous acetonitrile. An ultrasonic probe of 24 kHz frequency has been used for this study.
Hamid Reza, Memarian, Asadollah, Farhadi
openaire   +2 more sources

An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

Molecules, 2015
We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions.
Yonghong Zhang, Bin Wang, Xiaomei Zhang, Jianbin Huang, Chenjiang Liu   +4 more
doaj   +1 more source

An Efficient One-Pot Protocol for the Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones Using Metallophthalocyanines (MPcs) as Potent Heterogeneous Catalysts: Synthesis, Characterization, Aggregation and Antimicrobial Activity

Molecules, 2017
In this study, novel phthalonitrile 3 and their corresponding metal-free 4 and metallophthalocyanine derivatives 5–7 bearing 2-isopropenyl-4-methoxy-1-methylbenzene groups were synthesized and characterized. 3,4-Dihydropyrimidinones have been synthesized
Naceur Hamdi, Rawdha Medyouni, Hallouma Bilel, Lamjed Mansour, Antonio Romerosa   +4 more
doaj   +1 more source

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Molecules, 2020
A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea.
Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga   +8 more
doaj   +1 more source