Results 11 to 20 of about 843 (203)

Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β-Lactamase Inhibitors. [PDF]

Chem Biol Drug Des
A series of new substituted 1,6‐dihydropyrimidinones was designed, synthesized, and biologically evaluated as potential antibacterial candidates and β ‐lactamase enzyme inhibitors.
Soliman AM, Allam HA, Mahmoud WR, Naguib BH.   +3 more
europepmc   +3 more sources

Synthesis and characterization of functionalized dihydropyrimidinones via one-pot isocyanide-based three-component reaction of N-formyl urea and dialkyl ACETYLENEDICARBOXYLATES [PDF]

Bulletin of the Chemical Society of Ethiopia, 2017
The reactive intermediate generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates was trapped by N-formyl urea to produce highly functionalized dihydropyrimidinones in fairly good yields.
A. Naderi, B. Mohtat
doaj   +2 more sources

H2SO4-Silica Catalyzed One-Pot and Efficient Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions [PDF]

E-Journal of Chemistry, 2011
H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields ...
Seied Ali Pourmousavi, Maryam Hasani
doaj   +2 more sources

Skeletal rearrangement in Biginelli reaction for the synthesis of chromenoquinoline fused spirohydantoins and their in silico cytotoxicity study [PDF]

Scientific Reports
Although Biginelli reaction is known to generate dihydropyrimidinones having wide arrays of phramacological properties, herein we report an unprecedented skeletal rearrangement in Biginelli reaction to synthesize pharmacologically versatile imidazolidine-
Mezhubeinuo, Hemanta Bordoloi, Anurag Pratim Saikia, Ghanashyam Bez   +3 more
doaj   +2 more sources

Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea

Beilstein Journal of Organic Chemistry, 2014
The three-component reactions of aldehydes, electron deficient alkynes and ureas/thioureas have been smoothly performed to yield a class of unprecedented 3,4-dihydropyrimidinones and thiones (DHPMs).
Jie-Ping Wan, Yunfang Lin, Kaikai Hu, Yunyun Liu   +3 more
doaj   +2 more sources

Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel

Molecules, 2016
An efficient one-pot synthesis of 1,2,3-triazole derivatives of dihydropyrimidinones has been developed using two multicomponent reactions. The aldehyde-1,2,3-triazoles were obtained in good yields from in situ-generated organic azides and O ...
Rodrigo González-Olvera, Viridiana Román-Rodríguez, Guillermo E. Negrón-Silva, Araceli Espinoza-Vázquez, Francisco Javier Rodríguez-Gómez, Rosa Santillan   +5 more
doaj   +2 more sources

Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst [PDF]

Journal of Sciences, Islamic Republic of Iran, 2015
A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using  holmium chloride as catalyst.
S. Kakaei, H. Sid Kalal, H. Hoveidi
doaj   +2 more sources

O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization [PDF]

Beilstein Journal of Organic Chemistry
A one-pot three-component Biginelli synthesis of dihydropyrimidinones/thiones/selenones via acetic acid or solvent-free Yb(OTf)3-catalyzed tandem reaction of β-ketosulfone (dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide), an appropriate urea, and ...
Kateryna V. Dil, Vitalii A. Palchykov
doaj   +2 more sources

Development of Dithioacetal-Modified Dihydropyrimidone Derivatives with Potential Anti-Inflammatory Activity for Inflammatory Bowel Disease. [PDF]

Chem Biodivers
This study designed and synthesized dithioacetal‐modified dihydropyrimidinone derivatives (30). Compound D3 showed optimal anti‐inflammatory activity, inhibiting the MAPK/NF‐κB pathway, reducing NO secretion (IC50 = 1.2 µM), and ameliorating DSS‐induced acute colitis in mice, offering a new candidate for inflammatory bowel disease therapy.
Jiang JW, Dong R, Cao Q, Wang H, Li SY, Zhang GP, Wang QY.   +6 more
europepmc   +2 more sources

DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]

Chem Biodivers
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G, Mishra S, Seboletswe P, Gcabashe N, Gummidi L, Manhas N, Makhanya T, Bhargava G, Idris A, Islam MS, Singh P.   +10 more
europepmc   +2 more sources