Results 11 to 20 of about 1,311 (206)

Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions

Molecules, 2007
This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.
Manisha Sathe
exaly   +3 more sources

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction [PDF]

Molecules
The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Marcos Díaz-Fernández, Manuel Algarra, Saturnino Calvo-Losada, José-Joaquín Quirante, Francisco Sarabia, María-Soledad Pino-González   +5 more
doaj   +2 more sources

Defect-rich MOF-303 as a dual acid–base heterogeneous catalyst for the one-pot Biginelli synthesis of dihydropyrimidinones [PDF]

Scientific Reports
Bifunctional MOF-303 (Al) exhibits promising catalytic activity for the Biginelli reaction. However, its intrinsic microporosity may hinder reactant and product diffusion and reducing efficiency. Introducing defects is crucial for enhancing its catalytic
Nuhaa Shaheed, Ahmad Shaabani
doaj   +2 more sources

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative [PDF]

Frontiers in Pharmacology, 2021
Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen   +4 more
doaj   +2 more sources

Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7 [PDF]

The Scientific World Journal, 2012
Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent-free, and eco-friendly conditions in a one-pot reaction of 1,3-dicarbonyl compounds, aldehydes, and urea/thiourea/acetyl thiourea ...
Harshita Sachdeva, Diksha Dwivedi
doaj   +4 more sources

O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization [PDF]

Beilstein Journal of Organic Chemistry
A one-pot three-component Biginelli synthesis of dihydropyrimidinones/thiones/selenones via acetic acid or solvent-free Yb(OTf)3-catalyzed tandem reaction of β-ketosulfone (dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide), an appropriate urea, and ...
Kateryna V. Dil, Vitalii A. Palchykov
doaj   +2 more sources

Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O [PDF]

Journal of the Brazilian Chemical Society, 2004
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described.
Russowsky Dennis, Lopes Fabrício A., Silva Victor S. S. da, Canto Karen F. S., D'Oca Marcelo G. Montes, Godoi Marla N.   +5 more
doaj   +2 more sources

DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]

Chem Biodivers
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G, Mishra S, Seboletswe P, Gcabashe N, Gummidi L, Manhas N, Makhanya T, Bhargava G, Idris A, Islam MS, Singh P.   +10 more
europepmc   +2 more sources

Antioxidant Compounds in the Treatment of Alzheimer's Disease: Natural, Hybrid, and Synthetic Products. [PDF]

Evid Based Complement Alternat Med, 2023
Alzheimer’s disease (AD) which is associated with cognitive dysfunction and memory lapse has become a health concern. Various targets and pathways have been involved in AD’s progress, such as deficit of acetylcholine (ACh), oxidative stress, inflammation, β‐amyloid (Aβ) deposits, and biometal dyshomeostasis.
Hatami M, Mortazavi M, Baseri Z, Khani B, Rahimi M, Babaei S.   +5 more
europepmc   +2 more sources

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources