A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV [PDF]
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite +11 more
wiley +2 more sources
DES‐Promoted Synthesis of 3,4‐Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies [PDF]
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar +10 more
wiley +2 more sources
Antioxidant Compounds in the Treatment of Alzheimer’s Disease: Natural, Hybrid, and Synthetic Products [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2023, Issue 1, 2023., 2023 Alzheimer’s disease (AD) which is associated with cognitive dysfunction and memory lapse has become a health concern. Various targets and pathways have been involved in AD’s progress, such as deficit of acetylcholine (ACh), oxidative stress, inflammation, β‐amyloid (Aβ) deposits, and biometal dyshomeostasis.
Maryam Hatami +6 more
wiley +2 more sources
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures [PDF]
Beilstein Journal of Organic Chemistry, 2022 A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported.
Sangram Gore +2 more
doaj +2 more sources
Multigram‐Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients [PDF]
ChemSusChem, Volume 18, Issue 13, July 1, 2025.Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Christos M. Chatzigiannis +3 more
wiley +2 more sources
Aryl-Substituted Dihydro-Pyrimidines Effecting Kinesin Eg5 as Novel Approach for Cancer Treatment [PDF]
MoleculesCancer is one of the most lethal diseases of this century. Unfortunately, many anticancer agents have harsh side effects or fail to work against cancer any longer due to tolerance.
Dialekti Chlorou, Eleni Pontiki
doaj +2 more sources
Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation [PDF]
Beilstein Journal of Organic Chemistry, 2020 Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ...
Kumar Godugu +5 more
doaj +2 more sources
Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds [PDF]
ChemMedChem, Volume 21, Issue 2, January 2026.Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley +2 more sources
Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction [PDF]
MoleculesThe relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Marcos Díaz-Fernández +5 more
doaj +2 more sources
Defect-rich MOF-303 as a dual acid–base heterogeneous catalyst for the one-pot Biginelli synthesis of dihydropyrimidinones [PDF]
Scientific ReportsBifunctional MOF-303 (Al) exhibits promising catalytic activity for the Biginelli reaction. However, its intrinsic microporosity may hinder reactant and product diffusion and reducing efficiency. Introducing defects is crucial for enhancing its catalytic
Nuhaa Shaheed, Ahmad Shaabani
doaj +2 more sources