Dihydropyrimidinones Against Multiresistant Bacteria [PDF]
Frontiers in Microbiology, 2022 The increase in bacterial resistance to antimicrobials has led to high morbidity and mortality rates, posing a major public health problem, requiring the discovery of novel antimicrobial substances.
Marisa Castro Jara +10 more
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Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5 [PDF]
Molecules, 2021 Solvothermal synthesis of multiple dihydropyrimidinones at a time has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts or additives.
Xiao-Qiang Jiang +5 more
doaj +4 more sources
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures [PDF]
Beilstein Journal of Organic Chemistry, 2022 A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported.
Sangram Gore +2 more
doaj +2 more sources
Aryl-Substituted Dihydro-Pyrimidines Effecting Kinesin Eg5 as Novel Approach for Cancer Treatment [PDF]
MoleculesCancer is one of the most lethal diseases of this century. Unfortunately, many anticancer agents have harsh side effects or fail to work against cancer any longer due to tolerance.
Dialekti Chlorou, Eleni Pontiki
doaj +2 more sources
Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation [PDF]
Beilstein Journal of Organic Chemistry, 2020 Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ...
Kumar Godugu +5 more
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Molecules, 2017 An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation.
Fei Zhao, Xiuwen Jia, Pinyi Li
exaly +3 more sources
Molecules, 2007 This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.
Manisha Sathe
exaly +3 more sources
Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction [PDF]
MoleculesThe relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Marcos Díaz-Fernández +5 more
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Defect-rich MOF-303 as a dual acid–base heterogeneous catalyst for the one-pot Biginelli synthesis of dihydropyrimidinones [PDF]
Scientific ReportsBifunctional MOF-303 (Al) exhibits promising catalytic activity for the Biginelli reaction. However, its intrinsic microporosity may hinder reactant and product diffusion and reducing efficiency. Introducing defects is crucial for enhancing its catalytic
Nuhaa Shaheed, Ahmad Shaabani
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Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative [PDF]
Frontiers in Pharmacology, 2021 Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou +4 more
doaj +2 more sources