Results 61 to 70 of about 843 (203)

An Environmentally Friendly Solvent-free Synthesis of 3,4-Dihydropyrimidinones using a p-Aminobenzene Sulfonic Acid Catalyzed Biginelli Reaction [PDF]

, 2015
Anhydrous p-aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones by the cyclocondensation of aldehydes, β-ketoesters and urea/thiourea.
Wu, MS, Zhang, XZ, He, P
core  

Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities

ChemistrySelect, Volume 10, Issue 38, October 13, 2025.
Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK, Satya Sree Nannapaneni, Rambabu Gundla, Naresh Kumar Katari   +3 more
wiley   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions

E-Journal of Chemistry, 2011
In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one ...
Taoues Boumoud, Boudjemaa Boumoud, Paul Mosset, Abdelmadjid Debache   +3 more
doaj   +1 more source

One-pot synthesis of dihydropyrimidinones using iodotrimethylsilane. Facile and new improved protocol for the biginelli reaction at room temperature

, 2003
A novel one pot condensation of an aldehyde, β-ketoester and urea has been performed using TMSI in acetonitrile for the first time at room temperature affording dihydropyrimidinones in excellent ...
Sabitha, Gowravaram, Yadav, J. S., Kiran Kumar Reddy, G. S., Srinivas Reddy, Ch.   +3 more
core   +1 more source

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla   +6 more
wiley   +1 more source

Design, Synthesis, Photophysical, Theoretical, and Electrochemical Characterization of Novel Organochalcogen‐DHPM‐Triazole Hybrids

ChemistrySelect, Volume 10, Issue 22, June 11, 2025.
A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo, Patrick C. Nobre, Mateus H. Köhler, Bernardo A. Iglesias, Vanessa Nascimento   +4 more
wiley   +1 more source

ANÁLISE CONFORMACIONAL DE COMPOSTOS DE BIGINELLI COM ATIVIDADE ANTINEOPLÁSICA

Eclética Química, 2018
Dihydropyrimidinones, such as monastrol and analogues, are heterocycles with known antineoplastic activity. Conformational  analysis represents an important preliminary step in structure-activity correlation studies. Herein we describe the conformational
Marcelo Volpatto Marques, Denis Russowsky, L. M. A. Fontoura   +2 more
doaj   +1 more source

Biopolymer Catalysed Synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4- Tetrahydropyrimidine-2-ones and Evaluation of their Anti-bacterial and Anti-tubercular Activities [PDF]

, 2019
Background: An efficient one-pot biocatalysed ultrasound assisted synthesis of dihydropyrimidinones/ thiones has been developed under solvent free conditions.
Anuruddha Chabukswar, Kalpana Handore, Digamber Pawar, Pravin Adhav, Swati Jagdale, Vishwas Gaikwad, Sabrina Dallavalle, Suresh Shisodia, Balasaheb Diwate, Vasant Chabukswar   +9 more
core   +2 more sources

A practical and green approach towards synthesis of dihydropyrimidinones without any solvent or catalyst

, 2002
A simple, efficient, green, and cost-effective procedure has been developed for the synthesis of dihydropyrimidinones by a solvent-free and catalyst-free Biginelli's condensation of 1,3-dicarbonyl compound, aldehyde, and urea.
Hajra, Alakananda, Dey, Suvendu S., Ranu, Brindaban C.   +2 more
core   +1 more source