Results 61 to 70 of about 393 (166)
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.Heat‐shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70’s dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target ...
Amrita Arup Roy +9 more
wiley +1 more source
Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions
E-Journal of Chemistry, 2011 In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one ...
Taoues Boumoud +3 more
doaj +1 more source
Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124
Acta Crystallographica Section F, Volume 80, Issue 11, Page 314-319, November 2024.This study presents the crystal structure of transforming growth factor β type I receptor (TβR1) in complex with SB505124, highlighting the specific contacts that SB505124 makes with TβR1 and comparing these interactions with those of SB431542.The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in ...
Jhon A. Rodriguez Buitrago +2 more
wiley +1 more source
E-Journal of Chemistry, 2011 H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields ...
Seied Ali Pourmousavi, Maryam Hasani
doaj +1 more source
ANÁLISE CONFORMACIONAL DE COMPOSTOS DE BIGINELLI COM ATIVIDADE ANTINEOPLÁSICA
Eclética Química, 2018 Dihydropyrimidinones, such as monastrol and analogues, are heterocycles with known antineoplastic activity. Conformational analysis represents an important preliminary step in structure-activity correlation studies. Herein we describe the conformational
Marcelo Volpatto Marques +2 more
doaj +1 more source
Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 19, May 21, 2024.This review insights the pharmacological activity of naphthyl substituted chalcone derivatives. The anticancer and antibacterial activities were more explored than other activities. The presence of methoxy and naphthyl moiety enhanced the anticancer activity. The antibacterial activity was increased by electron withdrawing groups.
Priyanka Mahesha, Nitinkumar S. Shetty
wiley +1 more source
Journal of Chemistry, 2013 Al(NO3)3 · 9H2O efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a β-dicarbonyl compound, and urea or thiourea in refluxing ethanol and solvent-free (SF) conditions to afford the corresponding dihydropyrimidinones in high
Eskandar Kolvari, Maryam Mirzaeeyan
doaj +1 more source
Update on chiral recognition mechanisms in separation science
Journal of Separation Science, Volume 47, Issue 9-10, May 2024.The stereospecific analysis of chiral molecules is an important issue in many scientific fields. In separation sciences, this is achieved via the formation of transient diastereomeric complexes between a chiral selector and the selectand enantiomers driven by molecular interactions including electrostatic, ion‐dipole, dipole‐dipole, van der Waals or π ...
Gerhard K. E. Scriba
wiley +1 more source
Biochemistry Research International, Volume 2024, Issue 1, 2024.Eg5 is a protein encoded by KIF11 gene and is primarily involved in correct mitotic cell division. It is also involved in nonmitotic processes such as polypeptide synthesis, protein transport, and angiogenesis. The scientific literature sheds light on the ubiquitous functions of KIF11 and its involvement in the onset and progression of different ...
Alessia Ricci +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2011 Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl ...
Bruno Piqani, Wei Zhang
doaj +1 more source