Results 61 to 70 of about 392 (166)

Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2018
The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets.
Itamar Luís Gonçalves, Luciano Porto Kagami, Gustavo Machado das Neves, Liliana Rockenbach, Leonardo Davi, Alceu Felipe Soares, Solange Cristina Garcia, Vera Lucia Eifler-Lima   +7 more
doaj   +1 more source

Eg5 and Diseases: From the Well‐Known Role in Cancer to the Less‐Known Activity in Noncancerous Pathological Conditions

Biochemistry Research International, Volume 2024, Issue 1, 2024.
Eg5 is a protein encoded by KIF11 gene and is primarily involved in correct mitotic cell division. It is also involved in nonmitotic processes such as polypeptide synthesis, protein transport, and angiogenesis. The scientific literature sheds light on the ubiquitous functions of KIF11 and its involvement in the onset and progression of different ...
Alessia Ricci, Simone Carradori, Amelia Cataldi, Susi Zara, Anup Pathania   +4 more
wiley   +1 more source

EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS EFFICIENT CATALYSTS

Journal of the Turkish Chemical Society, Section A: Chemistry, 2017
A simple, efficient and green procedure has been developed for the synthesis of dihydropyrimidinones (Products of Biginelli) using phosphate fertilizers (mono-ammonium phosphate (MAP), di-ammonium phosphate (DAP) and triple super phosphate (TSP)) as ...
Sarra SIBOUS, Said BOUKHRIS, Rachida GHAILANE, Nouzha HABBADI, Amina HASSIKOU, Abdelaziz SOUIZI   +5 more
doaj   +1 more source

Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea

Beilstein Journal of Organic Chemistry, 2014
The three-component reactions of aldehydes, electron deficient alkynes and ureas/thioureas have been smoothly performed to yield a class of unprecedented 3,4-dihydropyrimidinones and thiones (DHPMs).
Jie-Ping Wan, Yunfang Lin, Kaikai Hu, Yunyun Liu   +3 more
doaj   +1 more source

Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst [PDF]

Journal of Sciences, Islamic Republic of Iran, 2015
A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using  holmium chloride as catalyst.
S. Kakaei, H. Sid Kalal, H. Hoveidi
doaj  

Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel

Molecules, 2016
An efficient one-pot synthesis of 1,2,3-triazole derivatives of dihydropyrimidinones has been developed using two multicomponent reactions. The aldehyde-1,2,3-triazoles were obtained in good yields from in situ-generated organic azides and O ...
Rodrigo González-Olvera, Viridiana Román-Rodríguez, Guillermo E. Negrón-Silva, Araceli Espinoza-Vázquez, Francisco Javier Rodríguez-Gómez, Rosa Santillan   +5 more
doaj   +1 more source

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

Molecules, 2009
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described.
Ji-De Wang, Chen-Jiang Liu
doaj   +1 more source

Synthesis And Bioactivity of Dihydropyrimidinone (DHPM) Derivatives

European Chemical Bulletin
Dihydropyrimidinones (DHPMs) is an main type of heterocyclic compounds whih shows biological activities. This review/article focuses on the synthetic strategies employed for the construction of DHPM frameworks and highlights their bioactivity profiles across various pharmacological targets.
Ganesh L. Kirdat, Onkar S. Dhindale, Tushar M. Dalimbkar, Mr. Nikhil A. Mandlik   +3 more
openaire   +2 more sources

Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O

Journal of the Brazilian Chemical Society, 2004
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described.
Russowsky Dennis, Lopes Fabrício A., Silva Victor S. S. da, Canto Karen F. S., D'Oca Marcelo G. Montes, Godoi Marla N.   +5 more
doaj  

Exploring substituted 3,4-dihydropyrimidinone and thione derivatives as anti-prostate cancer agents: Computational screening, synthesis, characterization, and in vitro efficacy assessment

Journal of Saudi Chemical Society
Despite decades of research, anticancer medication therapy is still largely constrained to prevent growth and limit the spread of tumour cells.
M.K.M. Abdul Lathiff, R. Suresh, R. Senthamarai, Sivakumar Annadurai, Richie R. Bhandare, Afzal B. Shaik   +5 more
doaj   +1 more source