Results 51 to 60 of about 843 (203)

STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013
The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei, Sara Malek, Mohammad Reza Sheikhi, Mohammad Kazem Mohammadi   +3 more
doaj  

Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer and glioblastoma: A review

Results in Chemistry, 2023
Breast cancer and gliobalstoma are the most aggressive types of diseases causing serious health issues. Potent anticancer molecules are facing serious side effects which arouse the need for newer molecules with significant clinical efficacy and safety ...
Dhirajkumar Nikam, Anurekha Jain
doaj   +1 more source

Antibacterial Studies of Dihydropyrimidinones and Pyrimidinethiones [PDF]

Journal of Bacteriology & Mycology: Open Access, 2017
Some new dihydro pyrimidinone and pyrimidinethione compounds have been synthesized and their antibacterial activities have been studied in dimethyl formamide and dimethyl sulphoxide against some Gram positive and Gram negative bacteria For this Agar well diffusion method is used It is observed that inhibition depends on solvent bacterial strain ...
openaire   +1 more source

An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System [PDF]

Journal of Sciences, Islamic Republic of Iran, 2014
An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green ...
B. Pouramiri, E. Tavakolinejad Kermany, H. Khajesamani, H. Khabazzadeh   +3 more
doaj  

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Cobalt supported on alumina as green catalyst for Biginelli reaction in mild conditions: effect of catalyst preparation method

Green Processing and Synthesis, 2017
Cobalt supported on alumina (10 wt% Co/Al2O3) was synthesized by three different methods; sol-gel (SG), microemulsion (ME) and impregnation (IMP). The materials were characterized by the Brunauer-Emmett-Teller (BET) method, X-ray diffraction (XRD), X-ray
Khiar Chahinaz, Tassadit Mazari, Bennini Leila, Halouane Mourad, Benito González Manuel Jesús, Menad Saliha, Tezkratt Said, Rabia Chérifa   +7 more
doaj   +1 more source

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

Frontiers in Pharmacology, 2021
Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen   +4 more
doaj   +1 more source

Demonstration of the Feasibility of a Direct Solid-Phase Split-Pool Biginelli Synthesis of 3,4-Dihydropyrimidinones

, 2016
A direct, Lewis acid-catalyzed Biginelli synthesis of 3,4-dihydropyrimidinones has been performed on high-capacity polystyrene macrobeads with a polymer O-silyl-attached N-(3-hydroxypropyl)urea. Resin−urea was first reacted separately with either 4-bromo-
Michael J. Lusch (2707972), John A. Tallarico (308350)   +1 more
core   +1 more source

New Anticancer 4‐Aryldihydropyrimidinone‐5‐Carboxylates Targeting Hsp90

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Cinzia Bordoni, Tia Z. Elstow, Andrea Brancale, Richard W. E. Clarkson, Andrew D. Westwell   +4 more
wiley   +1 more source

Antidiabetic Evaluation of New Pyrimidine‐Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +8 more
wiley   +1 more source