Results 51 to 60 of about 393 (166)

New Anticancer 4‐Aryldihydropyrimidinone‐5‐Carboxylates Targeting Hsp90

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Cinzia Bordoni, Tia Z. Elstow, Andrea Brancale, Richard W. E. Clarkson, Andrew D. Westwell   +4 more
wiley   +1 more source

Antidiabetic Evaluation of New Pyrimidine‐Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +8 more
wiley   +1 more source

An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System [PDF]

Journal of Sciences, Islamic Republic of Iran, 2014
An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green ...
B. Pouramiri, E. Tavakolinejad Kermany, H. Khajesamani, H. Khabazzadeh   +3 more
doaj  

Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities

ChemistrySelect, Volume 10, Issue 38, October 13, 2025.
Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK, Satya Sree Nannapaneni, Rambabu Gundla, Naresh Kumar Katari   +3 more
wiley   +1 more source

Cobalt supported on alumina as green catalyst for Biginelli reaction in mild conditions: effect of catalyst preparation method

Green Processing and Synthesis, 2017
Cobalt supported on alumina (10 wt% Co/Al2O3) was synthesized by three different methods; sol-gel (SG), microemulsion (ME) and impregnation (IMP). The materials were characterized by the Brunauer-Emmett-Teller (BET) method, X-ray diffraction (XRD), X-ray
Khiar Chahinaz, Tassadit Mazari, Bennini Leila, Halouane Mourad, Benito González Manuel Jesús, Menad Saliha, Tezkratt Said, Rabia Chérifa   +7 more
doaj   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla   +6 more
wiley   +1 more source

Design, Synthesis, Photophysical, Theoretical, and Electrochemical Characterization of Novel Organochalcogen‐DHPM‐Triazole Hybrids

ChemistrySelect, Volume 10, Issue 22, June 11, 2025.
A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo, Patrick C. Nobre, Mateus H. Köhler, Bernardo A. Iglesias, Vanessa Nascimento   +4 more
wiley   +1 more source

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng, Sa Du, Rui Yuan, Yuan Zeng, Xuefen Li, Yu‐Wei Wu, Ke Chen, Lei Tao, Zhihui Tang, Xuliang Deng   +9 more
wiley   +1 more source

Synthesis And Bioactivity of Dihydropyrimidinone (DHPM) Derivatives

European Chemical Bulletin
Dihydropyrimidinones (DHPMs) is an main type of heterocyclic compounds whih shows biological activities. This review/article focuses on the synthetic strategies employed for the construction of DHPM frameworks and highlights their bioactivity profiles across various pharmacological targets.
Ganesh L. Kirdat, Onkar S. Dhindale, Tushar M. Dalimbkar, Mr. Nikhil A. Mandlik   +3 more
  +5 more sources