Results 31 to 40 of about 3,167 (267)

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation [PDF]

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
openalex   +2 more sources

Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators [PDF]

ACS Omega, 2022
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugated dihydropyrimidinones using a synthetic approach that is well suited for obtaining compound libraries ...
Sabera Bijani, Faraz Shaikh, Sheefa Mirza, Shirley Weng In Siu, Nayan Jain, Rakesh Rawal, Nigel G. J. Richards, Anamik Shah, Ashish Radadiya   +8 more
openaire   +2 more sources

Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines [PDF]

Organic Letters, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kana, Yamamoto, Ye Grace, Chen, Frédéric G, Buono   +2 more
openaire   +2 more sources

Catalytic Evaluation of Surface Engineered Activated Carbon with SnO ₂ Nanoparticles for Synthesis of Dihydropyrimidinones at Room Temperature

Organic Preparations and Procedures International
Sunil B. Jagtap, Dnyanoba B. Muley, Abhijeet S. Patki, Sushil R. Mathapati   +3 more
openalex   +3 more sources

Biochar-Based Graphitic Carbon Nitride Adorned with Ionic Liquid Containing Acidic Polymer: A Versatile, Non-Metallic Catalyst for Acid Catalyzed Reaction

Molecules, 2020
A novel biochar-based graphitic carbon nitride was prepared through calcination of Zinnia grandiflora petals and urea. To provide acidic and ionic-liquid functionalities on the prepared carbon, the resultant biochar-based graphitic carbon nitride was ...
Samahe Sadjadi, Fatemeh Koohestani, Majid Heravi   +2 more
doaj   +1 more source

Bis-bromine-1,4-diazabicyclo[2.2.2]octane Complex (DABCO-Br2): An Efficient and Versatile Reagent for Preparation of Dihydropyrimidinones as a New Protocol for the Biginelli Reaction [PDF]

شیمی کاربردی روز, 2011
A simple and efficient method for the one-pot Biginelli condensation reaction of aldehydes, β-dicarbonyl compounds and urea or thiourea employing tetrameric DABCO-bromine as a novel catalyst is described.
Gholam Hossein Mahdavinia, Mohammad Ali Bigdeli, Samaneh Karimi, Fatemeh Koti   +3 more
doaj   +1 more source

Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**

ChemMedChem, Volume 18, Issue 20, October 17, 2023., 2023
One quinazolin‐2,4,6‐triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin‐2,4,6‐triamine derivatives acted as superoxide scavengers, and one 5,6‐dihydro‐3H‐pirimidin‐4‐one showed bXO inhibitory activity ...
Marcela A. Lopez‐Sanchez, María del Carmen Garcia‐Rodriguez, Rodrigo Aguayo‐Ortiz, Estefani Hernandez‐Cruz, Diego I. Figueroa‐Figueroa, Francisco Hernandez‐Luis   +5 more
wiley   +1 more source

Synthesis and Characterization of Two 3,4-Dihydropyrimidinone Derivatives

Diyala Journal For Pure Science, 2018
Noor Raisan Ali, Mahmood Shakir Magtoof
openalex   +2 more sources

Novel core–shell magnetic nanoparticles@Zeolitic imidazolate with glycerol‐nickel for the synthesis of dihydropyrimidinones

Applied organometallic chemistry, 2023
The present study reported a novel and eco‐friendly synthesis of Fe3O4@ZIF‐8@Glycerol‐Ni nanocatalyst via a multistep process. The as‐prepared catalyst was used due to its high efficiency, low cost, and biocompatibility for the fabrication of ...
Ahmad Poursattar Marjani, Fatemeh Asadzadeh, Aria Danandeh Asl   +2 more
semanticscholar   +1 more source