Results 21 to 30 of about 1,824 (162)

Can dimedone be used to study selenoproteins? An investigation into the reactivity of dimedone toward oxidized forms of selenocysteine [PDF]

Protein Science, 2018
AbstractDimedone is a widely used reagent to assess the redox state of cysteine‐containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and reversibility of this label in a model peptide ...
N Connor, Payne, Drew R, Barber, Erik L, Ruggles, Robert J, Hondal   +3 more
openaire   +2 more sources

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Redox Biology, 2018
The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes.
David E. Heppner, Milena Hristova, Tomoaki Ida, Ana Mijuskovic, Christopher M. Dustin, Virág Bogdándi, Jon M. Fukuto, Tobias P. Dick, Péter Nagy, Jianing Li, Takaaki Akaike, Albert van der Vliet   +11 more
doaj   +1 more source

Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2009
New potent antibacterials, fused isoxazole and pyrazole derivatives, were synthesized using 5,5-dimethylcyclohexane-1,3-dione (1) and 3-[(4-chlorobenzylidene)amino]-2-thioxoimidazolidin-4-one (2) as synthons. Aromatic aldehydes on condensation with 1 and
VIJAY V. DABHOLKAR, FAISAL Y. ANSARI
doaj   +3 more sources

Synthesis and Biological Evaluation of Some Newly Synthesized Barbiturates and Their Derivatives by Using Task Specific Ionic Liquid [Bmim]OH

Orbital: The Electronic Journal of Chemistry, 2019
Eco-friendly synthesis of some selected Barbiturates, Thiobarbiturates and Dimedone derivatives has been developed by using task specific ionic liquid Bmim[OH], which not only act as catalyst but also  are best solvent media for the Knoevenagel ...
Giribala Madhavrao Bondle, Sandeep T. Atkore   +1 more
doaj   +3 more sources

Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides

Journal of Saudi Chemical Society, 2020
A convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be
Rafaila Rafique, Syed Muhammad Saad, Arshia, Khalid Mohammed Khan, Shahnaz Perveen, Muhammad Taha   +5 more
doaj   +1 more source

Crystal structure of (E)-5,5-dimethyl-2-[3-(4-nitrophenyl)allylidene]cyclohexane-1,3-dione

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C17H17NO4, the cylohexane-1,3-dione ring adopts an envelope conformation with the dimethyl-subsituted C atom as the flap. Its mean plane is inclined to the benzene ring by 7.99 (19)°. The molecule has a trans conformation about the
Jae Kyun Lee, Sun-Joon Min, Yong Seo Cho, Jang Hyuk Kwon, Junghwan Park   +4 more
doaj   +1 more source

Phospho sulfonic acid: A novel and efficient solid acid catalyst for the one-pot preparation of 2H-indazolo[2,1-b]-phthalazine-triones [PDF]

Journal of the Serbian Chemical Society, 2013
The efficient one-pot condensation of aldehyde, dimedone, and phthalhydrazide has been achieved in the presence of a catalytic amount of phospho sulfonic acid as a novel environmentally benign heterogeneous solid acid under solvent-free conditions.
Kiasat Reza Ali, Mouradezadegun Arash, Saghanezhad Jafar Seyyed   +2 more
doaj   +1 more source

Structure and Spectroscopic Studies of Bis Azo Compounds with S/SO2 Bridges and Containing Cyclic-1,3-Dicarbonyl Groups

Gazi Üniversitesi Fen Bilimleri Dergisi, 2023
A series of new bis azo dyes were synthesized starting from aromatic diamine with S/SO2 bridges and cyclic-1,3-dicarbonyl groups; contain active methylene group, namely; 3,3-dimethyl-1,5-cyclohexadione (dimedone), 1,3-cyclohexadione and 2,2-dimethyl-1,3 ...
Gülnihal ERTEN, Naki ÇOLAK
doaj   +1 more source

Multi-component Reactions of Cyclohexan-1,3-diketones to Produce Fused Pyran Derivatives with Antiproliferative Activities and Tyrosine Kinases and Pim-1 Kinase Inhibitions

Acta Chimica Slovenica, 2021
In this work the multi-component reactions of either of the arylhydrazocyclohexan-1,3-dione derivatives 3a–c with either of benzaldehyde (4a), 4-chlorobenzaldehyde (4b) or 4-methoxybenzaldehyde (4c) and either malononitrile (5a) or ethyl cyanoacetate (5b)
Rafat M Mohareb, Rehab Ali Ibrahim, Ensaf Sultan Alwan   +2 more
doaj   +1 more source

A New Supported Manganese-Based Coordination Complex as a Nano-Catalyst for the Synthesis of Indazolophthalazinetriones and Investigation of Its Antibacterial Activity

Chemistry, 2021
A new magnetic supported manganese-based coordination complex (Fe3O4@SiO2@CPTMS@MBOL@ Mn) was prepared in consecutive stages and characterized via various techniques (VSM, SEM, TEM, XRD, FT-IR, EDX, TG-DTA, and ICP).
Maryam Ariannezhad, Davood Habibi, Somayyeh Heydari, Vahideh Khorramabadi   +3 more
doaj   +1 more source