TfWRKY40 positively regulates diosgenin biosynthesis in Trigonella foenum-graecum L. [PDF]
Frontiers in Plant ScienceDiosgenin is a bioactive steroidal natural product extraced from plants and serves as an important precursor for the industrial production of steroidal hormone drugs.
Chuanjia Xu +6 more
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Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments [PDF]
Frontiers in PharmacologyBackgroundTo comprehensively investigate the mechanism of action of Diosgenin elements against gastric cancer (GC).MethodsTargets of Diosgenin were collected from six databases, and enrichment analysis was used to identify its associated diseases and ...
Zhangjun Yun +9 more
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Therapeutic potential of diosgenin in hepatocellular carcinoma through molecular mechanisms and nanodelivery strategies [PDF]
Discover OncologyPurpose The review aims to comprehensively examine the anticancer potential of diosgenin, a natural steroidal sapogenin, in the context of hepatocellular carcinoma (HCC).
Charmi Jyotishi +3 more
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Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis [PDF]
Scientific ReportsThe prevalence of nonalcoholic steatohepatitis (NASH) is rising annually, posing health and economic challenges, with limited treatments available.
Peiyuan Gu +7 more
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The origin and evolution of the diosgenin biosynthetic pathway in yam
Plant Communications, 2021 Diosgenin, mainly produced by Dioscorea species, is a traditional precursor of most hormonal drugs in the pharmaceutical industry. The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.
Jian Cheng +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese medicine.
Yuan Zhou +8 more
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Diosgenin: Chemistry, extraction, quantification and health benefits
Food Chemistry Advances, 2023 The occurrence of natural bioactive compounds is increasingly involved with pharmaceutical industries' exploring more source matrices. Diosgenin is a lot of delved bioactive compound naturally occurring in Trigonella foenum graecum, Dioscorea alata ...
Prajya Arya +2 more
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Acta Crystallographica Section E Structure Reports Online, 2012 Diosgenin [or (22R,25R)-spirost-5-en-3β-ol] is the starting material of the Marker degradation, a cheap semi-synthesis of progesterone, which has been designated as an International Historic Chemical Landmark. Thus far, a single X-ray structure for diosgenin is known, namely its dimethyl sulfoxide solvate [Zhanget al.(2005).Acta Cryst.E61, o2324–o2325].
María-Guadalupe Hernández Linares +4 more
openaire +3 more sources
Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. [PDF]
PLoS ONE, 2011 BACKGROUND: Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as inhibiting proliferation and inducing apoptosis in a variety of tumor cells.
Pin-Shern Chen +3 more
doaj +1 more source
Systems and in vitro pharmacology profiling of diosgenin against breast cancer
Frontiers in Pharmacology, 2023 Aim: The purpose of this study was to establish a mode of action for diosgenin against breast cancer employing a range of system biology tools and to corroborate its results with experimental facts.Methodology: The diosgenin-regulated domains implicated ...
Pukar Khanal +9 more
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