Results 11 to 20 of about 4,332 (163)

Fabrication and Assessment of Diosgenin Encapsulated Stearic Acid Solid Lipid Nanoparticles for Its Anticancer and Antidepressant Effects Using in vitro and in vivo Models

Frontiers in Neuroscience, 2022
Inflammatory cascade plays a pivotal role in the onset and progression of major depressive disorder (MDD) and glioblastoma multiforme (GBM). Therefore, questing natural compounds with anti-inflammatory activity such as diosgenin can act as a double-edged
Hina Khan, Sadia Nazir, Rai Khalid Farooq, Ishaq N. Khan, Aneela Javed, Aneela Javed   +5 more
doaj   +1 more source

Unveiling the Molecular Profile and Antiviral Potential of Costus arabicus L. Against Zika Virus. [PDF]

Chem Biodivers
Analysis of the chemical profile and antiviral potential of Costus arabicus L. extracts. ABSTRACT Widely used in Brazilian folk medicine, Costus arabicus L. (Canarana) is a herbaceous plant with promising pharmacological potential. Here, we profile the molecular composition of extracts from different plant organs and evaluate their in vitro activity ...
Carvalho ARV, Reis JDE, Ferraz AC, da Silva Menegatto MB, da C Lopes J, Pamplona SDGSR, da Silva MN, de Brito Magalhães CL, Gomes PWP, Yoshioka E Silva CY.   +9 more
europepmc   +2 more sources

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao, Zilin Zhou, Zilin Zhou, Jia Sun, Changfu Li, Changfu Li, Yansheng Zhang, Yansheng Zhang   +7 more
doaj   +1 more source

Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy

Molecules, 2021
Although the anti-allergic and prebiotic activities of diosgenin have been reported, the influence of diosgenin on intestinal immune and epithelial cells remains unclear.
Chung-Hsiung Huang, Chorng-Liang Pan, Guo-Jane Tsai, Chun-Ju Chang, Wei-Chung Tsai, Shueh-Yu Lu   +5 more
doaj   +1 more source

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent

Journal of Lipid Research, 2009
Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel, J. Mark Brown, Yinyan Ma, Weiqing Tang, Lawrence L. Rudel, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +7 more
doaj   +1 more source

Diosgenin protects retinal pigment epithelial cells from inflammatory damage and oxidative stress induced by high glucose by activating AMPK/Nrf2/HO‐1 pathway

Immunity, Inflammation and Disease, 2022
Introduction Diosgenin is a natural steroidal compound with reported antidiabetic and many other protective properties. This study aimed to explore the protective effect of diosgenin on high‐glucose (HG)‐induced retinal pigment epithelial cells.
Yang Hao, Xuefeng Gao
doaj   +1 more source

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

BMC Complementary Medicine and Therapies, 2020
Background Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Diosgenin is a natural steroidal saponin with a variety of beneficial effects, including antidiabetic effects, and is a raw material for the ...
Jinhong Leng, Xiaohua Li, He Tian, Chang Liu, Yining Guo, Su Zhang, Yang Chu, Jian Li, Ying Wang, Ling Zhang   +9 more
doaj   +1 more source

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1

Cellular Physiology and Biochemistry, 2017
Background/Aims: We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs).
Won Seok Yang, Soo Young Moon, Mee Jeong Lee, Eun Kyoung Lee, Su-Kil Park   +4 more
doaj   +1 more source

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Open Life Sciences, 2021
Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties ...
Zhao Hengfang, Zhang Xiaoyan, Zhang Bojing, Qu Xiaoyuan   +3 more
doaj   +1 more source

Characterization of spray dried diosgenin from fenugreek using binary blend of carrier agents

Applied Food Research, 2022
The utilization of nutraceutical products is enhancing widely due to upcoming diseases. Consumption of bitter food is remarkably less irrespective of their health benefits.
Prajya Arya, Pradyuman Kumar
doaj   +1 more source