Results 51 to 60 of about 4,332 (163)

Comparative Transcriptome Analysis Identifies Genes Involved in Diosgenin Biosynthesis in Trigonella foenum-graecum L.

Molecules, 2019
Trigonella foenum-graecum L. (fenugreek) is a valuable resource of producing diosgenin which serves as a substrate for synthesizing more than two hundred kinds of steroidal drugs.
Chen Zhou, Xiaohua Li, Zilin Zhou, Changfu Li, Yansheng Zhang   +4 more
doaj   +1 more source

The Biochemical Role of Bitter Melon (Momordica charantia L.) Aqueous Extract in Regulating Hepatic Gluconeogenesis in Rats Fed Ketogenic Diet

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Metabolic effects of a ketogenic diet and bitter melon extract on hepatic gluconeogenesis and glucose–lipid homeostasis. ABSTRACT The ketogenic diet (KD) has been suggested as a useful lifestyle intervention for metabolic syndrome; however, its long‐term metabolic effects remain debated.
Ghalia Shamlan
wiley   +1 more source

Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. [PDF]

PeerJ
Dioscorea cirrhosa L. (D. cirrhosa) tuber is a traditional medicinal plant that is abundant in various pharmacological substances. Although diosgenin is commonly found in many Dioscoreaceae plants, its presence in D. cirrhosa remained uncertain.
Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo   +6 more
doaj   +2 more sources

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Oral administration of diosgenin protects optic nerve degeneration in a mouse model of normal-tension glaucoma

Phytomedicine Plus
Introduction: In glaucoma, degeneration of visual pathway spread whole brain area, suggesting that restoring the degenerated axons in the whole visual pathway is crucial for vision recovery.
Chihiro Tohda, Shogo Shibue
doaj   +1 more source

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Nature Communications, 2019
Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical ...
Bastien Christ, Chengchao Xu, Menglong Xu, Fu-Shuang Li, Naoki Wada, Andrew J. Mitchell, Xiu-Lin Han, Meng-Liang Wen, Makoto Fujita, Jing-Ke Weng   +9 more
doaj   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Comparative Profiling of Capsicum frutescens and C. annuum Reveals Superior Bioactivities and Nutritional Advantages for Functional Food Applications

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Systematic bioactivity profiling revealed C. frutescens demonstrated significantly superior radical scavenging capacity (DPPH IC50: 111.96 ± 3.24 μg/mL; 2.5‐fold enhancement, p < 0.001), enhanced broad‐spectrum antibacterial efficacy (zone diameters: 8–22 mm), and notable cytotoxic activity meeting NCI preliminary criteria (LC50: 29.24 ± 1.15 μg/mL ...
Shahin Akter, Muhammad Mamunur Rashid Mahib, Mohammad Razuanul Hoque, Md. Rafiqul Islam, Md. Golam Kabir   +4 more
wiley   +1 more source

Switchgrass Steroidal Saponins Reduce Fungal Disease but Decrease Yeast Fermentation Yield

GCB Bioenergy, Volume 18, Issue 1, January 2026.
Yeast fermentation of switchgrass biomass is inhibited for certain genotypes, especially those with high concentrations of steroidal saponins that protect against fungal disease. Inhibition can be reversed through (1) ergosterol addition, (2) fermentation with the bacterium Zymonomas mobilis, or (3) in different collection years.
Acer VanWallendael, Xingxing Li, Dan Xie, Kallysa Taylor, Evan Handowski, Jose Serate, Lillian M. Barten, Yaoping Zhang, Kurt Thelen, Robert L. Last, Trey K. Sato, David B. Lowry   +11 more
wiley   +1 more source