Results 11 to 20 of about 4,892 (216)

α-Glucosidase Inhibitory Potential of <i>Citrus reticulata</i> Peel-Derived Flavonoids-A Prelude for the Management of Type 2 Diabetes. [PDF]

Food Sci Nutr
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Baloyi IT, Rabbad AH, Gama NH, Malgas S.
europepmc   +2 more sources

Qualitative and quantitative analysis of diosmin content of hyssop (Hyssopus officinalis) in response to salinity stress

Heliyon, 2021
Hyssop (Hyssopus officinalis L.) is a perennial subshrub, which is distributed across the eastern Mediterranean region to central Asia. One of the most important bioactive compounds of hyssop is diosmin, a flavone glycoside of diosmetin, with application
Zhaleh Soheilikhah, Masoud Modarresi, Naser Karimi, Ali Movafeghi   +3 more
doaj   +1 more source

Correction to "Mechanistic Insight into Diosmin-Induced Neuroprotection and Memory Improvement in Intracerebroventricular-Quinolinic Acid Rat Model: Resurrection of Mitochondrial Functions and Antioxidants". [PDF]

Evid Based Complement Alternat Med
Evidence-Based Complementary and Alternative Medicine, Volume 2026, Issue 1, 2026.
europepmc   +2 more sources

Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach

BMC Complementary Medicine and Therapies, 2023
Background Interstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin is a naturally occurring flavonoid glycoside that has antioxidant, anti-inflammatory, and antifibrotic activities.
Wen-Man Zhao, Zhi-Juan Wang, Rui Shi, Yuyu Zhu, Xun-Liang Li, De-Guang Wang   +5 more
doaj   +1 more source

Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis

Frontiers in Cardiovascular Medicine, 2022
Chronic venous disease (CVD) is a progressive inflammatory disease that increases in prevalence with age. Elucidating the underlying molecular mechanism of CVD development is essential for disease prevention and treatment.
Zhiye Guo, Xiaolong Du, Yihua Zhang, Chunwan Su, Feng Ran, Qiulun Lu   +5 more
doaj   +1 more source

Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis

Micromachines, 2021
Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification.
Iulia Gabriela David, Alexandra-Gabriela Oancea, Mihaela Buleandră, Dana Elena Popa, Emilia Elena Iorgulescu, Adela Magdalena Ciobanu   +5 more
doaj   +1 more source

Diosmin/hesperidin: a cooperating tandem, or is diosmin crucial and hesperidin an inactive ingredient only? [PDF]

Vnitřní lékařství, 2020
With the advent of novel monocomponent venoactive drugs containing the flavonoid diosmin, the need has arisen to answer the question of therapeutic equivalence of the widely used micronized purified flavonoid fraction (MPFF) contained in Detralex and of the currently introduced monocomponent venoactive drugs.
Debora, Karetová, Josef, Suchopár, Jan, Bultas   +2 more
openaire   +2 more sources

Diosmin induces caspase-dependent apoptosis in human glioblastoma cells [PDF]

Anais da Academia Brasileira de Ciências, 2019
: Diosmin is a flavone glycoside clinically used as the main component of Daflon for the treatment of venous diseases. Several studies demonstrated that this natural compound can induce apoptosis in different tumors.
JULIANA M. SOARES, BRUNA M. DE FARIA, LUCAS M. ASCARI, SONIZA V. ALVES-LEON, JORGE M. DE SOUZA, ANTONIO G. SOARES, YRAIMA CORDEIRO, LUCIANA F. ROMÃO   +7 more
doaj   +2 more sources

Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells

BMC Complementary Medicine and Therapies, 2022
Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury. Methods First, we used CCK-
Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen   +5 more
doaj   +1 more source

Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study

Antioxidants, 2021
Hepatotoxicity caused by chemotherapeutic drugs (e.g., doxorubicin) is of critical concern in cancer therapy. This study focused on investigating the modulatory effects of diosmin against doxorubicin-induced hepatotoxicity in Male Wistar rats.
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali   +11 more
doaj   +1 more source