Results 11 to 20 of about 2,537 (174)

Flavonoid Inhibition of Bacillus licheniformis LP-8 Lipase: In Vitro and In Silico Insights Into Anti-Obesity Potential. [PDF]

ChemistryOpen
Bacillus licheniformis LP‐8, isolated from hot spring, produced lipase using waste frying oil. Flavonoids inhibited enzyme activity, confirmed by reduced activity assays. Molecular docking revealed hydrogen‐bond interactions within the lipase active site.
Bayrak S, Omeroglu MA, Senol H.
europepmc   +2 more sources

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum. [PDF]

Plant Biotechnol J
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Zhang Q, Wu Q, Shi W, Deng Y, Zhan R, Ma D.   +5 more
europepmc   +2 more sources

Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis

Frontiers in Cardiovascular Medicine, 2022
Chronic venous disease (CVD) is a progressive inflammatory disease that increases in prevalence with age. Elucidating the underlying molecular mechanism of CVD development is essential for disease prevention and treatment.
Zhiye Guo, Xiaolong Du, Yihua Zhang, Chunwan Su, Feng Ran, Qiulun Lu   +5 more
doaj   +1 more source

α-Glucosidase Inhibitory Potential of <i>Citrus reticulata</i> Peel-Derived Flavonoids-A Prelude for the Management of Type 2 Diabetes. [PDF]

Food Sci Nutr
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Baloyi IT, Rabbad AH, Gama NH, Malgas S.
europepmc   +2 more sources

Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis

Micromachines, 2021
Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification.
Iulia Gabriela David, Alexandra-Gabriela Oancea, Mihaela Buleandră, Dana Elena Popa, Emilia Elena Iorgulescu, Adela Magdalena Ciobanu   +5 more
doaj   +1 more source

Preparation, evaluation and pharmacokinetics of diosmin herbosome in beagle dogs

Pakistan Journal of Pharmaceutical Sciences, 2020
Diosmin is one of the most widely used phlebotonic drugs, but its poor bioavailability has restricted its usage. The aim of this study was to formulate a complex Diosmin with phospholipids (75% in PC, in 1:2 molar ratios) and to evaluate for solubility ...
Imene Adouani, Anas Sarwar Qureshi, Tai-Jun Hang   +2 more
doaj   +1 more source

Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells

BMC Complementary Medicine and Therapies, 2022
Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury. Methods First, we used CCK-
Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen   +5 more
doaj   +1 more source

Diosmin induces caspase-dependent apoptosis in human glioblastoma cells [PDF]

Anais da Academia Brasileira de Ciências, 2019
: Diosmin is a flavone glycoside clinically used as the main component of Daflon for the treatment of venous diseases. Several studies demonstrated that this natural compound can induce apoptosis in different tumors.
JULIANA M. SOARES, BRUNA M. DE FARIA, LUCAS M. ASCARI, SONIZA V. ALVES-LEON, JORGE M. DE SOUZA, ANTONIO G. SOARES, YRAIMA CORDEIRO, LUCIANA F. ROMÃO   +7 more
doaj   +2 more sources

Diosmin/hesperidin: a cooperating tandem, or is diosmin crucial and hesperidin an inactive ingredient only? [PDF]

Vnitřní lékařství, 2020
With the advent of novel monocomponent venoactive drugs containing the flavonoid diosmin, the need has arisen to answer the question of therapeutic equivalence of the widely used micronized purified flavonoid fraction (MPFF) contained in Detralex and of the currently introduced monocomponent venoactive drugs.
Debora, Karetová, Josef, Suchopár, Jan, Bultas   +2 more
openaire   +2 more sources

Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study

Antioxidants, 2021
Hepatotoxicity caused by chemotherapeutic drugs (e.g., doxorubicin) is of critical concern in cancer therapy. This study focused on investigating the modulatory effects of diosmin against doxorubicin-induced hepatotoxicity in Male Wistar rats.
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali   +11 more
doaj   +1 more source