Results 21 to 30 of about 2,537 (174)

Assessment of Platelet Reactivity and Inflammatory Markers in Coronary Artery Bypass Graft Patients Treated with Acetylsalicylic Acid with Flavonoid Supplementation

Molecules, 2021
The recommended pharmacological therapy for patients with coronary artery disease (CAD) treated by coronary artery bypass grafting (CABG) is acetylsalicylic acid (ASA).
Aldona Siennicka, Magdalena Kłysz, Monika Adamska, Kornel Chełstowski, Andrzej Biskupski, Maria Jastrzębska   +5 more
doaj   +1 more source

Effect of Diosmin on Selected Parameters of Oxygen Homeostasis

International Journal of Molecular Sciences, 2023
Chronic venous disease (CVD) is a condition characterized by functional disturbances in the microcirculation of the superficial and deep veins, affecting up to 30% of the global population. Diosmin, a phlebotropic drug, is commonly used in the treatment of CVD, and its beneficial effects have been described in numerous clinical studies.
Marcin Feldo, Magdalena Wójciak, Sławomir Dresler, Paweł Sowa, Bartosz J. Płachno, Dariusz Samborski, Ireneusz Sowa   +6 more
openaire   +4 more sources

Nephroprotective Effect of Diosmin against Cisplatin-Induced Kidney Damage by Modulating IL-1β, IL-6, TNFα and Renal Oxidative Damage

Molecules, 2023
Cisplatin (CP) is a platinum compound of the alkylating agent class that is used for the treatment of various types of cancer. However, CP treatments in cancer patients are accountable for nephrotoxicity, as it is a major adverse effect.
Tarique Anwer, Saeed Alshahrani, Ahmad M. H. Somaili, Abdullah H. Khubrani, Rayan A. Ahmed, Abdulmajeed M. Jali, Ayed Alshamrani, Hina Rashid, Yousra Nomeir, Mohammad Khalid, Mohammad Firoz Alam   +10 more
doaj   +1 more source

Comparative Assessment of Quality Requirements for Medicinal Products Containing Diosmin

Регуляторные исследования и экспертиза лекарственных средств, 2023
Currently, there is an increase in preand post-approval testing of medicinal products containing diosmin and hence a need to unify approaches to standardisation of this group of pharmaceuticals. Moreover, the State Pharmacopoeia of the Russian Federation
N. P. Antonova, E. P. Shefer, S. S. Prokhvatilova, N. E. Semenova, V. N. Makukhin, S. A. Kuchugurin, M. S. Zotova   +6 more
doaj   +1 more source

Synthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats

Biochemistry Research International, 2015
In view of the established antidiabetic properties of zinc, the present study was aimed at evaluating the hypoglycemic properties of a new zinc-diosmin complex in high fat diet fed-low dose streptozotocin induced experimental type 2 diabetes in rats ...
Veerasamy Gopalakrishnan, Subramanian Iyyam Pillai, Sorimuthu Pillai Subramanian   +2 more
doaj   +1 more source

Diosmin Enhances the Anti-migration Activity of Curcumin Analog PGV-1 on Colorectal Cancer Cells

Indonesian Biomedical Journal
BACKGROUND: Diosmin enhances the cytotoxicity of Pentagamavunone-1 (PGV-1) in cancer cells. PGV-1 and diosmin are predicted to target several matrix metalloproteinases (MMPs) in metastatic cancer, including colorectal cancer, but the anti-migration ...
Muthi Ikawati, Rohmad Yudi Utomo, Novia Permata Hapsari, Edy Meiyanto, Chio Oka   +4 more
doaj   +1 more source

Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana

Frontiers in Plant Science
The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,
Hyo Lee, Sangkyu Park, Saet Buyl Lee, Jaeeun Song, Tae-Hwan Kim, Beom-Gi Kim   +5 more
doaj   +1 more source

Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence

Vascular Health and Risk Management, 2021
Michèle Cazaubon,1 Jean-Patrick Benigni,2 Marcio Steinbruch,3 Violaine Jabbour,4 Christelle Gouhier-Kodas4 1Private Vascular Specialist, Paris, France; 2Pedagogical Support Office, Faculty of Medicine Pitié-Salpétrière, Sorbonne University, Paris, France;
Cazaubon M, Benigni JP, Steinbruch M, Jabbour V, Gouhier-Kodas C   +4 more
doaj  

Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex

Brain Research Bulletin
Diosmin is a flavone glycoside with a confirmed therapeutic effectiveness on the chronic venous disorders. In this paper, the classical mouse depression model induced by LPS was established to explore the effect of Diosmin on depression.
Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Shao   +5 more
doaj   +1 more source

Potential of Chinese Mandarin Peel and Leaf (Agricultural Byproducts) as Candidate Ingredients for Functional Foods and Feeds

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Mandarin peel (with higher contents of the key bioactive compounds hesperidin, nobiletin, and tangeretin) and leaf (with richer chemical diversity) are potential candidate ingredients for functional foods and feeds. The key bioactive compounds (hesperidin, nobiletin, and tangeretin) have optimal conditions for daily consumption, achieved through three ...
Jing Chen, Qinggui Lei, Boyong Chen, Chao Zhang, Zhijian Zeng, Guodong Chen, Zhengming Qian, Wenhao Wang   +7 more
wiley   +1 more source