Results 21 to 30 of about 3,363 (198)
Saudi Pharmaceutical JournalChemotherapeutic drugs, such as doxorubicin (Dox), are commonly used to treat a variety of malignancies. However, Dox-induced cardiotoxicity limits the drug’s clinical applications.
Abdullah F. AlAsmari +8 more
doaj +2 more sources
Molecules, 2017 We investigate diosmin for its effect on the ARPE-19 human retinal pigment epithelial cells exposed to high glucose, a model of diabetic retinopathy (DR). After incubation for 4 days with a normal (5 mmol/L) concentration of D-glucose, ARPE-19 cells were
Wayne Young Liu +3 more
doaj +2 more sources
Molecules, 2019 Diosmin is a natural compound with a wide range of biological activity, e.g., it improves lymphatic drainage, supports microcirculation, and increases venous tone, and venous elasticity, hence, it is applied in the pharmacotherapy of chronic venous ...
Marcin Feldo +7 more
doaj +2 more sources
Heliyon, 2021 Hyssop (Hyssopus officinalis L.) is a perennial subshrub, which is distributed across the eastern Mediterranean region to central Asia. One of the most important bioactive compounds of hyssop is diosmin, a flavone glycoside of diosmetin, with application
Zhaleh Soheilikhah +3 more
doaj +1 more source
Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis
Frontiers in Cardiovascular Medicine, 2022 Chronic venous disease (CVD) is a progressive inflammatory disease that increases in prevalence with age. Elucidating the underlying molecular mechanism of CVD development is essential for disease prevention and treatment.
Zhiye Guo +5 more
doaj +1 more source
Preparation, evaluation and pharmacokinetics of diosmin herbosome in beagle dogs
Pakistan Journal of Pharmaceutical Sciences, 2020 Diosmin is one of the most widely used phlebotonic drugs, but its poor bioavailability has restricted its usage. The aim of this study was to formulate a complex Diosmin with phospholipids (75% in PC, in 1:2 molar ratios) and to evaluate for solubility ...
Imene Adouani +2 more
doaj +1 more source
Real-world effectiveness of a phlebotonic formulation combining diosmin, Ruscus, Melilotus and Vitis vinifera on symptoms and quality of life in patients with chronic venous and lymphatic disease: results from the VIVEMA Stasis observational study. [PDF]
Drugs ContextBackground: Chronic venous disease and lymphoedema frequently coexist, leading to significant symptom burden and impaired quality of life (QoL). Phlebotonic agents, such as diosmin, Ruscus aculeatus, Melilotus officinalis and Vitis vinifera, have ...
Avruscio G +5 more
europepmc +2 more sources
Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model
, 2021 The current study was designed to investigate the protective role of diosmin against cyclophosphamide-induced premature ovarian insufficiency (POI). Female Swiss albino rats received a single intraperitoneal dose of cyclophosphamide (200 mg/kg) followed ...
Hoda Y. Abdallah +5 more
core +1 more source
BMC Complementary Medicine and Therapies, 2022 Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury. Methods First, we used CCK-
Jiuhong Deng +5 more
doaj +1 more source
Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
, 2021 Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits.
Li-Chun Huang +6 more
core +1 more source