Results 51 to 60 of about 38,518 (252)

Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)

Molecules, 2014
Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of ...
Ngozi Justina Nwodo, Festus Basden C. Okoye, Daowan Lai, Abdessamad Debbab, Reto Brun, Peter Proksch   +5 more
doaj   +1 more source

Efficient model chemistries for peptides. I. Split-valence Gaussian basis sets and the heterolevel approximation in RHF and MP2

, 2007
We present an exhaustive study of more than 250 ab initio potential energy surfaces (PESs) of the model dipeptide HCO-L-Ala-NH2. The model chemistries (MCs) used are constructed as homo- and heterolevels involving possibly different RHF and MP2 ...
Alonso, J. L., Echenique, Pablo
core   +2 more sources

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway [PDF]

, 2008
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. These residues are recognized by E3 ubiquitin ligases called N-recognins. Ubr1 is the N-recognin of the yeast Saccharomyces cerevisiae.
A. Varshavsky, Abdel-Sater, Andreasson, C.-S. Hwang, Doble, Dornan, Forsberg, He, Homann, Hunter, Knippschild, Kwon, Lochhead, Poulsen, Ravid, Santangelo, Sasaki, Tasaki, Varshavsky, Varshavsky, Xie, Zenker   +21 more
core   +3 more sources

Using small-angle scattering and contrast matching to understand molecular packing in low molecular weight gels [PDF]

, 2020
It is difficult to determine exactly the molecular packing in the aggregates in low molecular weight gels. Attempts to understand the packing have been made using X-ray diffraction, but there are complications with drying and questions as to whether the ...
Abdizadeh, Haleh, Adams, Dave J., Brasnett, Christopher, Cui, Honggang, Dietrich, Bart, Draper, Emily R., Marrink, Siewert J., McAulay, Kate, Patmanidis, Ilias, Schweins, Ralf, Seddon, Annela, Su, Hao   +11 more
core   +6 more sources

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Peptide Transporter 1‐Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis

Advanced Science
Cancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet the rapid malignant growth and transformation, tumor cells dramatically increase the consumption of nutrients, such as amino acids.
Feifeng Song, Zhentao Zhang, Weifeng Liu, Tong Xu, Xiaoping Hu, Qiyue Wang, Wanli Zhang, Luqi Ge, Chengwu Zhang, Qing Hu, Hui Qin, Song Zhang, Xinxin Ren, Weijiao Fan, Yiwen Zhang, Ping Huang   +15 more
doaj   +1 more source

Sidechain control of porosity closure in multiple peptide-based porous materials by cooperative folding [PDF]

, 2014
Porous materials find application in separation, storage and catalysis. We report a crystalline porous solid formed by coordination of metal centres with a glycylserine dipeptide.
Antypov, Dmytro, Berry, Neil G, Briggs, Michael, Chater, Philip A, Darling, George R, Khimyak, Yaroslav, Martí-Gastaldo, Carlos, Miller, Gordon J, Rosseinsky, Matthew J, Warren, John, Wiper, Paul V   +10 more
core   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses. [PDF]

PLoS ONE, 2016
The current study demonstrated that theasinensin A (TSA) had a potential to form the complex with hydrophobic Trp-containing dipeptides, and to reduce their membrane potential by artificial-lipid membrane taste sensor.
Jian Guo, Naoto Hirasaki, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Xiao Wu, Yusuke Tahara, Kiyoshi Toko, Toshiro Matsui   +8 more
doaj   +1 more source