Results 61 to 70 of about 38,518 (252)

Electron scattering from molecules and molecular aggregates of biological relevance [PDF]

, 2017
In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters.
Allan M, Allan M, Bouchiha D, Calegari F, Caprasecca S, Colyer C J, Colyer C J, da Costa R F, Denifl S, Dora A, Dubernet M L, Fabrikant I I, Fabrikant I I, Ferlay J, Fujimoto M M, Hall E, Herbert J M ed Parrill A L, Jensen F, Jimena D Gorfinkiel, Keller A, Linert I, Marangos J P, Nikjoo H, Ryszka M, Samukawa S, Slaughter D S, Surko C M, Sylwia Ptasinska, Trevisan C S, Vizcaino V, Winstead C, Zecca A, Zubek M, Ómarsson B   +33 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men. [PDF]

PLoS ONE, 2015
Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases ...
Sanne Stegen, Inge Everaert, Louise Deldicque, Silvia Vallova, Barbora de Courten, Barbara Ukropcova, Jozef Ukropec, Wim Derave   +7 more
doaj   +1 more source

Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study [PDF]

, 2015
Objectives: Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d-1 on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after ...
A Boldyrev, A Bruun, AA Boldyrev, AA Boldyrev, AA Boldyrev, AC Parrott, AM Asatoor, AM Hoffmann, AR Hipkiss, B Herculano, Bruno Gualano, C Sale, CA Hill, Catherine A. Brissette, Craig Sale, D Dobrota, Daniel Martin, DG Altman, DL Rothman, DL Rothman, E Hogervorst, G Aldini, Guilherme G. Artioli, H Abe, Hamilton Roschel, I Everaert, J Komura, Jacques Robertson, JE Preston, JN E-AS Baraniuk, JR Hoffman, JR Stroop, JW Harding, K Bauer, KN Chengappa, M Dunnett, M Gross, M Yazigi Solis, MA Kamal, Maria C. Otaduy, Marina Yazigi Solis, MS Horning, MS Ozdemir, NS Teuscher, OA Petroff, P Vermathen, R Hobson, R Leech, R Weinsier, RC Harris, Roger C. Harris, Ruth M Hobson, S Sternberg, S Stvolinsky, SB Cooper, Simon Cooper, SJ Kish, T McMorris, T Murakami, T Stellingwerff, TL Perry, TN Fedorova, Vitor S. Painelli   +62 more
core   +4 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against Aspergillus Species

Biomolecules
In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such as cattle, where fungal diseases can result in considerable economic losses, as well as in humans.
Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello   +10 more
doaj   +1 more source

Mechanistic Investigations of Oxidation of Some Dipeptides by Sodium N-chloro-p-toluenesulfonamide in Alkaline Medium:A Kinetic Study [PDF]

, 2008
The kinetics of oxidation of five dipeptides (DPP) viz., glycylglycine (Gly-Gly), L-alanyl-L-alanine (Ala-Ala), L-valyl-L-valine (Val-Val), L-leucyl-L-leucine (Leu-Leu) and phenylglycyl-phenylglycine (Phg-Phg) by sodium N-chloro-p-toluenesulfonamide or ...
Jagadeesh, R.V., Nirmala Vaz, ., Puttaswamy, .   +2 more
core   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Nematophin, an Antimicrobial Dipeptide Compound From Xenorhabdus nematophila YL001 as a Potent Biopesticide for Rhizoctonia solani Control

Frontiers in Microbiology, 2019
This study was conducted to purify and identify metabolites of antimicrobial activity against phytopathogens from Xenorhabdus nematophila YL001. Three dipeptide compounds were purified from its cell-free cultural broth and identified as (±)-nematophin ...
Shujing Zhang, Qi Liu, Yunfei Han, Jinghua Han, Zhiqiang Yan, Yonghong Wang, Xing Zhang   +6 more
doaj   +1 more source

Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase enzyme by dipeptides identified in dry-cured ham

Food Production, Processing and Nutrition, 2021
High cholesterolemia is a key risk factor for the development of cardiovascular diseases, which are the main cause of mortality in developed countries.
Alejandro Heres, Leticia Mora, Fidel Toldrá   +2 more
doaj   +1 more source