Results 81 to 90 of about 57,923 (191)

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope, Volume 4, Issue 9, September 2026.
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
wiley   +1 more source

Photocatalytic (3 + 2) dipolar cycloadditions of aziridines driven by visible-light. [PDF]

Chem Sci, 2023
Mazzarella D, Bortolato T, Pelosi G, Dell'Amico L.   +3 more
europepmc   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, Volume 32, Issue 33, 1 September 2026.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Stereoselective intramolecular 1,3-dipolar cycloadditions

, 2001
An in depth account of intramolecular 1,3-dipolar cycloadditions involving dipoles such as nitrile oxides, silyl nitronates, H-nitrones, azides, and nitrilimines is presented with particular emphasis on the stereochemistry during the cyclo addition ...
HASSNER, A, NAMBOOTHIRI, INN
core  

Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. [PDF]

Angew Chem Int Ed Engl, 2021
Yildirim O, Grigalunas M, Brieger L, Strohmann C, Antonchick AP, Waldmann H.   +5 more
europepmc   +1 more source

Cyclic Thiosulfinates: Synthesis and Applications in Chemical Biology and Materials Science

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Cyclic thiosulfinates (CTs) are strained organosulfur heterocyclic compounds with a polarized ─S(═O)─S─ bond that enables selective thiol reactivity. Advances in synthesis afford tunable scaffolds that support efficient proximal thiol cross‐linking and enable applications in chemical biology and materials science. Cyclic thiosulfinates (CTs) constitute
Benjamin Liebson, Jeffrey N. Agar, Roman Manetsch, Prakash T. Parvatkar   +3 more
wiley   +1 more source

A novel application of 2-silylated 1,3-dithiolanes for the synthesis of aryl/hetaryl-substituted ethenes and dibenzofulvenes

Beilstein Journal of Organic Chemistry, 2017
Trimethylsilyldiazomethane (TMS-CHN2) reacts readily with hetaryl thioketones to give sterically crowded 2-trimethylsilyl-4,4,5,5-tetrahetaryl-1,3-dithiolanes with complete regioselectivity at −75 °C as well as at rt.
Grzegorz Mlostoń, Paulina Pipiak, Róża Hamera-Fałdyga, Heinz Heimgartner   +3 more
doaj   +1 more source

Copper on Calcium Carbonate and Marble Waste as Recyclable Catalysts for Ultrasound‐Assisted One‐Pot Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
A sustainable CaCO3‐supported copper catalyst, prepared by simple adsorption of Cu(II) onto natural and marble waste‐derived carbonate materials, promotes ultrasound‐assisted CuAAC reaction in water. The work provides straightforward access to 1,4‐disubstituted 1,2,3‐triazoles under mild conditions while combining catalyst recyclability with the ...
Riccardo Serra, Dipak J. Fartade, Pietro Caboni, Cristina Carucci, Andrea Salis, Enrica Tuveri, Antonella Rossi, Andrea Citarella, Andrea Porcheddu   +8 more
wiley   +1 more source

A Novel Cycloaddition Reaction of Thermally Generated Sulfenes

CHIMIA, 1992
The highly strained ?-sultine 4, resulting from the addition of SO2 to benzobenzvalene, is shown to undergo a thermal cycloreversion which gives 1H-indene-1-thiocarbaldehyde dioxide (6) as an intermediate and subsequently 1H-indene-1 ...
Ulrich Burger, Serge P. Schmidlin, Jiri Mareda, Gerald Bernardinelli   +3 more
doaj   +2 more sources

SuFExable NH-Pyrazoles via 1,3-Dipolar Cycloadditions of Diazo Compounds with Bromoethenylsulfonyl Fluoride. [PDF]

J Org Chem, 2022
Yamanushkin P, Kaya K, Feliciano MAM, Gold B.   +3 more
europepmc   +1 more source