Results 111 to 120 of about 4,264,667 (244)

Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing

Cell Reports
Summary: It has been widely recognized that the microbiota has the capacity to shape host gene expression and physiological functions. However, there remains a paucity of comprehensive study revealing the host transcriptional landscape regulated by the ...
Zihe Xu, Xiaoqi Zheng, Jiajun Fan, Yuting Jiao, Sihao Huang, Yingyuan Xie, Shunlan Xu, Yi Lu, Anrui Liu, Runzhou Liu, Ying Yang, Guan-Zheng Luo, Tao Pan, Xiaoyun Wang   +13 more
doaj   +1 more source

A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes

Nature Communications, 2019
The Oxford Nanopore system is capable of direct RNA sequencing but complex transcriptome analysis still remains to be thoroughly investigated. Here the authors perform sequencing of native RNA as well as cDNA to characterise the strengths and weaknesses ...
Charlotte Soneson, Yao Yao, Anna Bratus-Neuenschwander, Andrea Patrignani, Mark D. Robinson, Shobbir Hussain   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

Demultiplexing and barcode-specific adaptive sampling for nanopore direct RNA sequencing

Nature Communications
Nanopore direct RNA sequencing (dRNA-seq) enables unique insights into RNA biology. However, applications are currently limited by the lack of accurate and cost-effective sample multiplexing. Here we introduce WarpDemuX, an ultra-fast and highly accurate
Wiep van der Toorn, Patrick Bohn, Wang Liu-Wei, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Redmond P. Smyth, Max von Kleist   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

RNA modification detection using direct RNA sequencing and nanoDoc2_3

, 2022
RNA modification detection using direct RNA sequencing and ...
openaire   +3 more sources

Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m 5 C at GCU motifs

Life Science Alliance
Published predictions of 5-methylcytosine at GCU sites inferred from direct RNA sequencing and the Tombo Alternative Model should be reconsidered unless further validated with orthogonal methods.
Kaylee J Watson, Robin E Bromley, Benjamin C Sparklin, Mark T Gasser, Tamanash Bhattacharya, Jarrett F Lebov, Tyonna Tyson, Nan Dai, Laura E Teigen, Karen T Graf, Jeremy M Foster, Michelle Michalski, Vincent M Bruno, Amelia RI Lindsey, Ivan R Corrêa, Richard W Hardy, Irene LG Newton, Julie C Dunning Hotopp   +17 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source