Results 1 to 10 of about 192,797 (169)

Editorial: Disease-on-a-chip: from point-of-care to personalized medicine. [PDF]

Front Pharmacol, 2023
[Excerpt] Introduction Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application across advanced technologies, such as Lab-on-chip platforms, Point-of-care systems, Organ-, Body- and ...
Cruz A, Fernandes E, Rodrigues RO, Catarino SO, Pinho D.   +4 more
europepmc   +10 more sources

A Real-Time Sensing System for Monitoring Neural Network Degeneration in an Alzheimer's Disease-on-a-Chip Model. [PDF]

Pharmaceutics, 2022
Stem cell-based in vitro models may provide potential therapeutic strategies and allow drug screening for neurodegenerative diseases, including Alzheimer’s disease (AD). Herein, we develop a neural stem cell (NSC) spheroid-based biochip that is characterized by a brain-like structure, well-defined neural differentiation, and neural network formation ...
Liu NC, Liang CC, Li YE, Lee IC.
europepmc   +4 more sources

Sistemas microfisiológicos compostos por organoides humanos em dispositivos microfluídicos: avanços e desafios [PDF]

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj   +11 more sources

Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform. [PDF]

Front Cardiovasc Med
Background Early-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL). Worldwide studies have revealed that aortic valve disease accounts for up to 43%
Mendoza-Seale M, Chen MH, Huang P, Mahler GJ.   +3 more
europepmc   +2 more sources

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions [PDF]

MedComm
Biomedical research models are undergoing continuous evolution, while conventional models (two‐dimensional/ three‐dimensional cultures and animal studies) face limitations in physiological relevance and ethical constraints.
Xuxia Cao, Congmin Xia, Caifeng Li, Shiwen Deng, Junxian Cao, Hongjun Yang, Shaoping Wang, Peng Chen   +7 more
doaj   +2 more sources

Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model. [PDF]

Mater Today Bio
Arellano A, Palma-Florez S, Cabrera P, Cortés-Adasme E, Bolaños K, Celis F, Araya-Vergara AJ, Pérez M, Crespo A, Matus MH, Araya E, Aldunate R, Kogan MJ, Samitier J, Lagunas A, Mir M, Hassan N.   +16 more
europepmc   +3 more sources

Corrigendum to “Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model” [Mater. Today Bio 35 (2025) 102453] [PDF]

Mater Today Bio
Arellano A, Palma-Florez S, Cabrera P, Cortés-Adasme E, Bolaños K, Celis F, Araya-Vergara A, Pérez M, Crespo A, Matus M, Araya E, Aldunate R, Kogan M, Samitier J, Lagunas A, Mir M, Hassan N.   +16 more
europepmc   +2 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source

3D bioprinted organ‐on‐chips

Aggregate, 2023
Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek, Nur Mustafaoglu, Yu Shrike Zhang, Savas Tasoglu   +5 more
doaj   +1 more source

Towards establishing human body-on-a-chip systems

Stem Cell Research & Therapy, 2022
Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj   +1 more source