A Real-Time Sensing System for Monitoring Neural Network Degeneration in an Alzheimer's Disease-on-a-Chip Model. [PDF]
Pharmaceutics, 2022 Stem cell-based in vitro models may provide potential therapeutic strategies and allow drug screening for neurodegenerative diseases, including Alzheimer’s disease (AD). Herein, we develop a neural stem cell (NSC) spheroid-based biochip that is characterized by a brain-like structure, well-defined neural differentiation, and neural network formation ...
Liu NC, Liang CC, Li YE, Lee IC.
europepmc +4 more sources
Disease-on-a-chip: mimicry of tumor growth in mammary ducts [PDF]
Lab Chip, 2014 We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces.
Vidi, Pierre-Alexandre +6 more
openaire +4 more sources
Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform. [PDF]
Front Cardiovasc MedBackground Early-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL). Worldwide studies have revealed that aortic valve disease accounts for up to 43%
Mendoza-Seale M +3 more
europepmc +2 more sources
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine. [PDF]
Front Pharmacol, 2023 Cruz A +4 more
europepmc +4 more sources
Application and prospects of lung organ-on-a-chip in the development of new drugs [PDF]
BioMedical Engineering OnLineRespiratory disease, such as lung cancer, is a major risk factor that seriously endangers human health. In the development of new drugs, conventional preclinical and clinical testing stages rely on cell culture and animal experiment.
Jun Su +5 more
doaj +2 more sources
Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model. [PDF]
Mater Today BioArellano A +16 more
europepmc +3 more sources
Corrigendum to “Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model” [Mater. Today Bio 35 (2025) 102453] [PDF]
Mater Today BioArellano A +16 more
europepmc +2 more sources
Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
doaj +1 more source
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj +7 more sources
Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
doaj +1 more source