Bioinspired NEMS-Prospective of Collaboration with Nature [PDF]
, 2022 The fields of micro- and nanomechanics are strongly interconnected with the development of micro-electro-mechanical (MEMS) and nano-electro-mechanical (NEMS) devices, their fabrication and applications.
Bokić, Bojana +3 more
core +4 more sources
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders [PDF]
, 2022 The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs.
Albani, Diego +4 more
core +4 more sources
Microfluidic Platforms to Unravel Mysteries of Alzheimer's Disease: How Far Have We Come? [PDF]
, 2021 Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease.
Chandra Goud, Macherla Sharath +12 more
core +3 more sources
Disease-on-a-chip: mimicry of tumor growth in mammary ducts [PDF]
Lab Chip, 2014 We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces.
Vidi, Pierre-Alexandre +6 more
openaire +3 more sources
Alveolus Lung-on-a-Chip Platform: A Proposal
Chemosensors, 2021 Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments ...
Noelia Campillo +2 more
doaj +1 more source
Entwicklung und Automatisierung 3D-gedruckter mikrofluidischer Systeme zur Integration und Kultivierung adhärenter Zellkulturen [PDF]
, 2022 Mikrofluidische Systeme werden zur Manipulation von Flüssigkeiten auf Mikroebene eingesetzt. Von ihnen profitieren insbesondere Biowissenschaften durch die Reduktion von Reagenzien und die Automatisierung ganzer Arbeitsabläufe.
Winkler, Steffen Nils
core +1 more source
Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends [PDF]
, 2022 Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research.
Carvalho, M. R. +14 more
core +1 more source
Advanced Science, 2022 Diabetes mellitus (DM) is closely related to Alzheimer's disease (AD), but individual cellular changes and the possibilities of recovery through molecular level regulation have not been investigated.
Minjeong Jang, Nakwon Choi, Hong Nam Kim
doaj +1 more source
Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development
Biosensors, 2022 An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering to replicate the critical physiological environment and functions of the human organs.
Zening Li +3 more
doaj +1 more source
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source