Results 21 to 30 of about 193,025 (292)
Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends [PDF]
, 2022 Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research.
Carvalho, M. R. +14 more
core +1 more source
Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development
Biosensors, 2022 An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering to replicate the critical physiological environment and functions of the human organs.
Zening Li +3 more
doaj +1 more source
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
The solitary nucleus connectivity to key autonomic regions in humans [PDF]
, 2022 The nucleus tractus solitarius (NTS) is a key brainstem structure relaying interoceptive peripheral information to the interrelated brain centres for eliciting rapid autonomic responses and for shaping longer-term neuroendocrine and motor patterns ...
Baron, Ralf +6 more
core +1 more source
Small, 2020 Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current approaches to monitoring of chemotherapy-induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early ...
Junmin Lee +18 more
semanticscholar +1 more source
In Vitro Microfluidic Models for Neurodegenerative Disorders [PDF]
, 2017 Microfluidic devices enable novel means of emulating neurodegenerative disease pathophysiology in vitro. These organ-on-a-chip systems can potentially reduce animal testing and substitute (or augment) simple 2D culture systems. Reconstituting critical
Marco Campisi +4 more
core +1 more source
Siphon-Controlled Automation on a Lab-on-a-Disc Using Event-Triggered Dissolvable Film Valves
Biosensors, 2021 Within microfluidic technologies, the centrifugal microfluidic “Lab-on-a-Disc” (LoaD) platform offers great potential for use at the PoC and in low-resource settings due to its robustness and the ability to port and miniaturize ‘wet bench’ laboratory ...
Brian D. Henderson +8 more
doaj +1 more source
Microphysiological systems: analysis of the current status, challenges and commercial future [PDF]
, 2018 The field of microphysiological systems (or organs-on-a-chip) experienced, in the past decade, a surge in publications and efforts towards commercialization. Such systems hold the promise to advance drug discovery, diagnostics, and many other areas.
Pawlikowsk, Joanna +2 more
core +3 more sources
Biosensors, 2023 Lab-on-a-chip (LOC) systems are miniaturized devices aimed to perform one or several analyses, normally carried out in a laboratory setting, on a single chip. LOC systems have a wide application range, including diagnosis and clinical biochemistry.
Margherita Borriello +10 more
doaj +1 more source
Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases
MedComm – Biomaterials and Applications, 2023 Cardiovascular disease (CVD) is currently a serious and growing public health problem. In tackling this challenge, organ‐on‐chip (OoC) technology, combined with cell culture and microfluidics, presents a powerful approach for constructing sophisticated ...
Jing Liu, Ying Wang
doaj +1 more source