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Molecular Biology Reports, 2023
The liver is one of the pivotal organs in the human body and is fundamentally responsible for detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease, fibrosis, cirrhosis, hepatocellular carcinoma, and hepatitis are associated with improper functions of the liver. Hence, biomarkers are needed to determine the severity.
Sukhbir Singh Tamber +4 more
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The liver is one of the pivotal organs in the human body and is fundamentally responsible for detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease, fibrosis, cirrhosis, hepatocellular carcinoma, and hepatitis are associated with improper functions of the liver. Hence, biomarkers are needed to determine the severity.
Sukhbir Singh Tamber +4 more
openaire +2 more sources
Biomarkers for Huntington's disease
Expert Opinion on Medical Diagnostics, 2008No treatments have yet been shown to slow the progression of the inherited neurodegenerative disorder Huntington's disease (HD) in humans, but several attempts at disease modification in animal models have been successful. Human clinical trials based on present clinical measures would require unfeasibly large subject numbers, particularly in ...
Edward J, Wild, Sarah J, Tabrizi
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Biomarkers in Alzheimer’s disease
Clinica Chimica ActaAlzheimer's disease (AD) is among the most common neurodegenerative disorders. AD is characterized by deposition of neurofibrillary tangles and amyloid plaques, leading to associated secondary pathologies, progressive neurodegeneration, and eventually death.
Kayalvizhi, Rajendran +1 more
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Sphingolipids as Biomarkers of Disease
2019Despite the advancements in modern medicine, there are still difficulties in diagnosing common illnesses. The invasiveness and price of the tests used to follow up certain diseases can be a barrier to proper patient follow-up. Sphingolipids are a diverse category of lipids.
Faris, Matanes +2 more
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On the Biomarkers of Alzheimer’s Disease
2020Nakamura et al. examined the evidence, using a discovery and a validation database, that amyloid-β precursor protein (APP)669-711/amyloid-β (Aβ)1-42 and Aβ1-40/Aβ1-42 ratios, and composites based on traditional statistics; they concluded that these may be useful as biomarkers of Alzheimer's Disease (AD).
Timon Cheng-Yi, Liu +4 more
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Biomarkers for Alzheimer’s disease
Expert Review of Neurotherapeutics, 2007The development and validation of biomarkers for the latent, prodromal and dementia stages of Alzheimer's disease (AD) is a pressing issue because of their high prevalence and an emerging set of experimental therapeutics that will soon force decisions regarding risk versus benefit.
Joshua A, Sonnen +6 more
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Biomarkers in Neurodegenerative Diseases
2017The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type of biomarkers has continued to grow for central nervous system diseases, from biofluid-based biomarkers (blood or cerebrospinal fluid (CSF)), to nucleic acids, tissue, and imaging.
Andreas, Jeromin, Robert, Bowser
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Biomarkers in Parkinson’s disease
Expert Review of Neurotherapeutics, 2006Parkinson's disease (PD) is a common neurodegenerative disorder that is largely diagnosed and managed clinically. Biomarkers, as indicators of underlying biological processes, offer the potential to identify individuals at risk for PD, screen new therapies, assist in the diagnosis and help optimize management of PD.
E Ray, Dorsey +2 more
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American Heart Journal, 2013
The development of diagnostic biomarkers of acute cardiovascular disease remains an important topic of interest given potential use to aid in early diagnosis. Cardiac biomarkers of ischemia and heart failure have already proven to be clinically useful.
Suzuki T +6 more
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The development of diagnostic biomarkers of acute cardiovascular disease remains an important topic of interest given potential use to aid in early diagnosis. Cardiac biomarkers of ischemia and heart failure have already proven to be clinically useful.
Suzuki T +6 more
openaire +4 more sources
Biomarkers for Alzheimer’s Disease
Current Alzheimer Research, 2019Alzheimer´s disease (AD) and related forms of dementia are increasingly affecting the aging population throughout the world, at an alarming rate. The World Alzheimer´s Report indicates a prevalence of 46.8 million people affected by AD worldwide. As population ages, this number is projected to triple by 2050 unless effective interventions are developed
Leonardo, Guzman-Martinez +4 more
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