Results 11 to 20 of about 744,500 (48)

Animal Models for Periodontal Disease [PDF]

open access: yes, 2011
Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host ...
Oz, Helieh S., Puleo, David A.
core   +4 more sources

Rabbit models of heart disease. [PDF]

open access: yes, 2008
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core  

A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]

open access: yes, 2017
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core   +1 more source

Neutrophils in animal models of autoimmune disease [PDF]

open access: yes, 2016
Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram   +151 more
core   +2 more sources

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. [PDF]

open access: yes, 2017
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an ...
Freeman, Lisa M   +4 more
core   +2 more sources

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

open access: yes, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
A Grunewald   +84 more
core   +1 more source

Improving translational studies: lessons from rare neuromuscular diseases [PDF]

open access: yes, 2015
Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
core   +3 more sources

Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations [PDF]

open access: yes, 2014
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA
CARTA, MANOLO, TRONCI, ELISABETTA
core   +1 more source

Risk assessment scenarios to understand the persistence of Rift Valley fever in Comoros (Indian Ocean) [PDF]

open access: yes, 2012
Rift Valley Fever (RVF) is an arbozoonosis identified for the first time in Kenya in the 1930s. In 2000, the first apparition of the virus out of Africa was described in the Arabian Peninsula with both animal and human cases.
Cardinale, Eric   +5 more
core  

SyntenyVista [PDF]

open access: yes, 2004
Visualization of genome comparisons is an important research tool in biology, medicine and agricultural research. We present a new visualization system, SyntenyVista, which allows for interactive exploration of genome comparisons. It incorporates a novel
Hanlon, N., Hunt, E.
core   +1 more source

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