Results 11 to 20 of about 1,905,801 (316)
Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
BMC Medicine, 2022 Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD ...
Rui Chen +8 more
doaj +1 more source
Similarities and differences in placental development between humans and cynomolgus monkeys
Reproductive Medicine and Biology, 2023 Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto +3 more
doaj +1 more source
Animal models of renal disease [PDF]
Kidney International, 2008 Mice have become a favored species to model disease. Many mouse strains have proven relatively resistant to some manipulations that have generated renal disease in other species. Kirchhoff et al. describe a means of producing hypertension, proteinuria, and glomerular sclerosis in a mouse strain.
Susztak, K. +3 more
openaire +2 more sources
Animal Models of Alzheimer's Disease [PDF]
International Journal of Alzheimer's Disease, 2010 The necessity for a deeper understanding of neurological diseases such as Alzheimer's disease (AD) that increase in frequency as a function of age has become of paramount importance with the coming of age of the baby boom generation and the increasing social demands for individuals to perform better and longer.
Casadesus, Gemma +3 more
openaire +3 more sources
Genome Medicine, 2022 Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.
Rui Chen +8 more
doaj +1 more source
Circadian Disruption and Metabolic Disease: Findings from Animal Models [PDF]
, 2010 Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one.
Arble, Deanna M. +3 more
core +2 more sources
Animal models of neurodegenerative diseases [PDF]
Nature Neuroscience, 2018 Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit ...
Ted M. Dawson +2 more
openaire +2 more sources
Virology Journal, 2020 Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu +6 more
doaj +1 more source
Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China
BMC Infectious Diseases, 2021 Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern.
Yu Wang +6 more
doaj +1 more source
, 2011 Objective This study was conducted with sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and arthritis and lupus-like disease animal models to identify innate immune system-dependent and -independent ...
Burmester, G. +5 more
core +2 more sources