Results 11 to 20 of about 1,810,523 (315)

Parathyroid Diseases and Animal Models [PDF]

Frontiers in Endocrinology, 2012
CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone.
Masaaki Inaba, Yasuo Imanishi, Yuki Nagata   +2 more
openaire   +4 more sources

Animal models of neurodegenerative diseases [PDF]

Revista Brasileira de Psiquiatria, 2013
The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able
Ribeiro, Fabiola Mara, Camargos, Elizabeth Ribeiro da Silva, Souza, Leonardo Cruz de, Teixeira, Antonio Lucio   +3 more
openaire   +5 more sources

Animal models of Parkinson’s disease [PDF]

The FEBS Journal, 2012
Animal models of Parkinson’s disease (PD) have been widely used in the past four decades to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder. These models have been classically based on the systemic or local (intracerebral) administration of neutoxins that are able to replicate most of the pathological and phenotypic ...
Blandini F., Armentero M. -T.
openaire   +7 more sources

Animal Models of Cardiovascular Diseases [PDF]

BioMed Research International, 2011
Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos, Gomez-Guerrero, Carmen, Martin-Ventura, Jose Luis, Blanco-Colio, Luis, Lavín Plaza, Begoña, Mallavia, Beñat, Tarin, Carlos, Mas, Sebastian, Ortiz, Alberto, Egido, Jesus   +9 more
openaire   +3 more sources

Animal Models of Parkinson's Disease [PDF]

Parkinson's Disease, 2011
Parkinson's disease (PD) is considered a multifactorial disorder, which is neuropathologically characterized by age-dependent neurodegeneration of dopaminergic neurons in the midbrain. Different neurotoxins including synthetic compounds, heavy metals, and dopamine itself have been proposed to be environmental risk factors of PD.
Katerina Venderova, David S. Park, Huaibin Cai, Enrico Schmidt, Yuzuru Imai   +4 more
openaire   +3 more sources

Animal Models of Alzheimer's Disease [PDF]

International Journal of Alzheimer's Disease, 2010
The necessity for a deeper understanding of neurological diseases such as Alzheimer's disease (AD) that increase in frequency as a function of age has become of paramount importance with the coming of age of the baby boom generation and the increasing social demands for individuals to perform better and longer.
Casadesus, Gemma, Arendash, Gary, Laferla, Frank, McDonald, Mike   +3 more
openaire   +4 more sources

Animal models of renal disease [PDF]

Kidney International, 2008
Mice have become a favored species to model disease. Many mouse strains have proven relatively resistant to some manipulations that have generated renal disease in other species. Kirchhoff et al. describe a means of producing hypertension, proteinuria, and glomerular sclerosis in a mouse strain.
Markus Bitzer, Katalin Susztak, Thomas H. Hostetter, Timothy W. Meyer   +3 more
openaire   +3 more sources

Animal Models of Alzheimer Disease [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Significant insights into the function of genes associated with Alzheimer disease and related dementias have occurred through studying genetically modified animals. Although none of the existing models fully reproduces the complete spectrum of this insidious human disease, critical aspects of Alzheimer pathology and disease processes can be ...
LaFerla, Frank M, Green, Kim N
openaire   +4 more sources

Animal Models for Periodontal Disease [PDF]

BioMed Research International, 2011
Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro.
David A. Puleo, Helieh S. Oz
openaire   +3 more sources

Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

Virology Journal, 2020
Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu, Chuan Qin   +6 more
doaj   +1 more source