Results 11 to 20 of about 1,056,424 (268)
Animal models of renal disease [PDF]
Kidney International, 2008 Mice have become a favored species to model disease. Many mouse strains have proven relatively resistant to some manipulations that have generated renal disease in other species. Kirchhoff et al. describe a means of producing hypertension, proteinuria, and glomerular sclerosis in a mouse strain.
Markus Bitzer +3 more
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Animal Models of Alzheimer's Disease [PDF]
International Journal of Alzheimer's Disease, 2010 The necessity for a deeper understanding of neurological diseases such as Alzheimer's disease (AD) that increase in frequency as a function of age has become of paramount importance with the coming of age of the baby boom generation and the increasing social demands for individuals to perform better and longer.
Casadesus, Gemma +3 more
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Viruses, 2022 Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process.
Ying Lu +6 more
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Similarities and differences in placental development between humans and cynomolgus monkeys
Reproductive Medicine and Biology, 2023 Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto +3 more
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Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
BMC Medicine, 2022 Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD ...
Rui Chen +8 more
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Animal Models for Periodontal Disease [PDF]
BioMed Research International, 2011 Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro.
David A. Puleo, Helieh S. Oz
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Animal models of autoimmune diseases [PDF]
Rheumatology International, 1997 Failure of distinction between self and non-self is regarded a critical event in the pathogenesis of several human diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, uveoretinitis or diabetes mellitus.
J. R. Kalden, H. Burkhardt
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Genome Medicine, 2022 Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.
Rui Chen +8 more
doaj +1 more source
Animal Models of Alzheimer Disease [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 Significant insights into the function of genes associated with Alzheimer disease and related dementias have occurred through studying genetically modified animals. Although none of the existing models fully reproduces the complete spectrum of this insidious human disease, critical aspects of Alzheimer pathology and disease processes can be ...
LaFerla, Frank M, Green, Kim N
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Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China
BMC Infectious Diseases, 2021 Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern.
Yu Wang +6 more
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