Results 21 to 30 of about 1,056,424 (268)

Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

Virology Journal, 2020
Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu, Chuan Qin   +6 more
doaj   +1 more source

Animal Models of Airway Diseases [PDF]

, 2011
Over the past 20 years, the growing awareness that purinergic signaling events literally shape the immune and inflammatory responses to infection and allergic reactions warranted the development of animal models to assess their importance in vivo in acute lung injury and chronic airway diseases.
Michael R. Blackburn, Linda F. Thompson, Maryse Picher   +2 more
openaire   +2 more sources

Gain and loss events in the evolution of the apolipoprotein family in vertebrata

BMC Evolutionary Biology, 2019
Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers.
Jia-Qian Liu, Wen-Xing Li, Jun-Juan Zheng, Qing-Nan Tian, Jing-Fei Huang, Shao-Xing Dai   +5 more
doaj   +1 more source

WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome

Biology, 2022
(1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1.
Hongyan Li, Fang Liu, Hanzhe Kuang, Hua Teng, Siyi Chen, Sijing Zeng, Qimin Zhou, Zhaokai Li, Desheng Liang, Zhuo Li, Lingqian Wu   +10 more
doaj   +1 more source

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Nature Communications, 2019
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting ...
Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema   +20 more
doaj   +1 more source

Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

Virology Journal, 2021
Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus.
Xin Li, Yafen Yu, Fengchao Lang, Guijun Chen, Erlin Wang, Lihong Li, Zhuoran Li, Liping Yang, Xia Cao, Nigel W. Fraser, Jumin Zhou   +10 more
doaj   +1 more source

Isolation of Joint-infiltrating Cells

Bio-Protocol, 2016
Infiltration of leukocytes into joints is one of the main features of autoimmune inflammatory arthritis. Here, we describe the protocol for isolation of joint-infiltrating cells in mice.
Aoi Akitsu, Yoichiro Iwakura
doaj   +1 more source

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

BMC Medicine, 2023
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms.
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao   +13 more
doaj   +1 more source

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

Scientific Reports, 2017
The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging.
Hong-Yi Zheng, Ming-Xu Zhang, Min Chen, Jin Jiang, Jia-Hao Song, Xiao-Dong Lian, Ren-Rong Tian, Xiao-Liang Zhang, Lin-Tao Zhang, Wei Pang, Gao-Hong Zhang, Yong-Tang Zheng   +11 more
doaj   +1 more source

Animal models in neurodegenerative diseases [PDF]

, 2007
Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well known and the neuronal loss well characterized.
openaire   +4 more sources