Results 21 to 30 of about 1,905,801 (316)
Animal Models for Periodontal Disease [PDF]
BioMed Research International, 2011 Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro.
Oz, Helieh S., Puleo, David A.
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Animal models of autoimmune diseases [PDF]
Rheumatology International, 1997 Failure of distinction between self and non-self is regarded a critical event in the pathogenesis of several human diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, uveoretinitis or diabetes mellitus.
Burkhardt, H., Kalden, J. R.
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Gain and loss events in the evolution of the apolipoprotein family in vertebrata
BMC Evolutionary Biology, 2019 Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers.
Jia-Qian Liu +5 more
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Animal models of NASH: getting both pathology and metabolic context right [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
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Animal Models of Cardiovascular Diseases [PDF]
BioMed Research International, 2011 Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos +9 more
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Biology, 2022 (1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1.
Hongyan Li +10 more
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Improving translational studies: lessons from rare neuromuscular diseases [PDF]
, 2015 Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
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Animal Models for Neural Diseases [PDF]
Toxicologic Pathology, 2010 “Animal Models of Neural Disease” was the focus of General Session 5 at a 2010 scientific symposium that was sponsored jointly by the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP).
Gary W, Jay +5 more
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Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
Nature Communications, 2019 Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting ...
Tomoyuki Tsukiyama +20 more
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Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes
Virology Journal, 2021 Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus.
Xin Li +10 more
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