Results 51 to 60 of about 1,899,644 (265)

Translatability score revisited: differentiation for distinct disease areas [PDF]

, 2017
Background: Translational science supports successful transition of early biomedical research into human applications. In 2009 a translatability score to assess risk and identify strengths and weaknesses of a given project has been designed and ...
Wehling, Martin, Wendler, Alexandra
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]

, 2016
Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian, Curiel, David T, Debatis, Michele, Dmitriev, Igor P, Kashentseva, Elena A, Kim, Hyeun Bum, Schmidt, Diane J, Shoemaker, Charles B, Steele, Jennifer A, Sun, Xingmin, Tremblay, Jacqueline M, Tzipori, Saul, Wang, Yaunkai   +12 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Animal Models in Behçet's Disease [PDF]

Pathology Research International, 2012
Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis ...
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]

, 2017
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core   +1 more source

Neutrophils in animal models of autoimmune disease [PDF]

, 2016
Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram, Ajuebor, Albanesi, Alves, Amaral, Askenasy, Attila Mócsai, Aube, Baik, Barnado, Bento, Binstadt, Braswell, Brinkmann, Buanne, Campbell, Campbell, Carlson, Carneiro-Sampaio, Chan, Chen, Chen, Chen, Chiriac, Christensen, Clifford A. Lowell, Coit, Coquery, Cronstein, Croxford, Cumpelik, Diana, Diana, Ditzel, Dwivedi, Ehrenstein, Elliott, Eyles, Forster, Fournier, Futosi, Gaipl, Garcia, Goldberg, Grayson, Guerreiro-Cacais, Guiducci, Gupta, Hattar, Heimbach, Helms, Henry, Heymann, Hickman, Holden, Huang, Kahlenberg, Kallenberg, Kaplan, Katayama, Kelkka, Kessenbrock, Kim, Kishida, Knight, Knight, Knight, Kovacs, Kuhl, Lamagna, Lande, Li, Lin, Lindwall, Liu, Lood, Maalouf, Maicas, Mancardi, Marciano, Marrakchi, Martinon, Mayadas, McColl, McGonagle, McGonagle, Merrill, Metzler, Metzler, Miller, Milora, Mocsai, Mocsai, Moline-Velazquez, Nemeth, Nesterovitch, O'Shea, Odobasic, Odobasic, Okumura, Ooi, Oswald, Palanichamy, Palmen, Patel, Pfister, Pieterse, Pietronigro, Pietrosimone, Rodrigues-Sousa, Rohrbach, Rumble, Ryckman, Sadik, Samavedam, Sangaletti, Scapini, Scapini, Schauer, Schmidt, Schon, Schon, Schreiber, Schreiber, Schreiber, Shao, Smith, Smith, So, Spengler, Steiger, Steinbach, Sumida, Summers, Tamás Németh, Terkeltaub, Tortola, Ueyama, van der Fits, Vandal, Volmering, Wallace, Walter, Willis, Wipke, Wise, Xiao, Yu, Zehntner, Zenaro, Zhang, Zhang   +151 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source