Results 101 to 110 of about 78,401 (264)

Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth [PDF]

, 2011
Disintegrins and disintegrins-like proteins are able to inhibit platelet aggregation and integrin-mediated cell adhesion. the aim of this study was to produce one disintegrin-like cloned from Bothrops leucurus venom gland and to characterize it regarding
Almeida, M. C., Araujo, Ronaldo Carvalho, Barros, C. C., Higuchi, D. A., Lang, E. A. S., Pesquero, J. L., Pesquero, João Bosco, Pesquero, P. R., Samaan, M., Sanchez, E. F.   +9 more
core   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Antitumor and anti-angiogenic activity of the recombinant human disintegrin domain of A disintegrin and metalloproteinase 15

Molecular Medicine Reports, 2015
A disintegrin and metalloproteinases (ADAMs), a family of transmembrane glycoproteins, are expressed in numerous tissues and organs, and have been implicated in a variety of physiological and pathological processes. ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain.
Ying, Hou, Min, Chu, Yanfei, Cai, Jianyong, Lei, Yun, Chen, Ruiyu, Zhu, Xiaohai, Gong, Xin, Ma, Jian, Jin   +8 more
openaire   +3 more sources

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology, 2020
Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl   +2 more
doaj   +1 more source

Emerging Roles of ADAM and ADAMTS Metalloproteinases in Cancer [PDF]

, 2008
A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs).
Cataldo, Didier, Crahay, Céline, El Hour, Mehdi, Foidart, Jean-Michel, Guéders, Maud, Noël, Agnès, Paulissen, Geneviève, Quesada Calvo, Florence, Rocks, Natacha   +8 more
core   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Gene expression and matrix turnover in overused and damaged tendons [PDF]

, 2005
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the
Abbaszade I, Akeson WH, Alfredson H, Amiel D, Archambault J, Astrom M, Bank RA, Banyard J, Benjamin M., Berenson MC, Boot-Handford RP, Brown PD., Cal S, Caterson B, Cawston TE, Cawston TE., Clark IM, Colige A, Colige A, Collins-Racie LA, Corps AN, Corps AN, Curwin SL, Dalton S, Dickinson SC, Eriksen HA, Everts V, Fernandes RJ, Fitzgerald J, Flannery CR, G. P. Riley, Gao G, Gelberman RH, Gillard GC, Gotoh M, Hannafin JA., Hardingham TE, Hashimoto T, Heinemeier K, Ireland D, Jarvinen M, Jozsa L, Jozsa L, Kannus P, Kannus P., Kannus P., Kashiwagi M, Kashiwagi M, Kaushal GP, Kjaer M, Koch M, Koch M, Koshy PJ, Koskinen SO, Kuno K, Langberg H, Langberg H, Langberg H, Leadbetter WB., Lehto M, McCawley LJ, McNeilly CM, Murphy G, Myllyharju J, Nagase H., Pace JM, Patterson-Kane JC, Pierfitte C, Rees SG, Riley G., Riley GP, Riley GP, Riley GP, Riley GP, Riley GP, Riley GP., Samiric T, Samiric T, Sandy JD, Sandy JD, Sandy JD, Sato K, Smith RK, Smith RK, Somerville RP, Tipton CM, Tortorella MD, Tortorella MD, Tsuzaki M, Vankemmelbeke MN, Vogel KG, Waggett AD, Wang P, Woo SLY, Woo SLY, Woo SLY, Yasuda K, Yoshihara Y   +97 more
core   +1 more source

Thirty Years of Autologous Platelet Concentrates: From Platelet‐Rich Plasma to Platelet‐Rich Fibrin

Journal of Periodontal Research, EarlyView.
This review highlights the 30 years of evolution of APCs, with a focus on their clinical applications and recent technological advancements. ABSTRACT Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice.
Richard J. Miron, Nathan E. Estrin, Paras Ahmad, Nima Farshidfar, Masako Fujioka‐Kobayashi, Yufeng Zhang, Mario Romandini, Reinhard Gruber   +7 more
wiley   +1 more source

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

Mediators of Inflammation, 2017
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies.
D. Dreymueller, K. Theodorou, M. Donners, A. Ludwig   +3 more
doaj   +1 more source

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source