Results 11 to 20 of about 78,401 (264)
Snake Venom Disintegrins and Cell Migration [PDF]
Toxins, 2010 Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement.
Heloisa S. Selistre-de-Araujo +3 more
doaj +3 more sources
ADAM-15 Disintegrin-Like Domain Structure and Function [PDF]
Toxins, 2010 The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu +3 more
doaj +3 more sources
EVALUATING THE EFFECTS OF DISINTEGRIN ON TUMOUR GROWTH [PDF]
Biotechnologia ActaCancer is the second leading cause of death in the world after cardiovascular disease, and many types of cancer have no symptoms in the early stages, making it difficult to diagnose.
O. M. PLATONOV, Y. D. VINNYCHUK
doaj +2 more sources
Recombinant and Chimeric Disintegrins in Preclinical Research
Toxins, 2018 Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental role in ...
Victor David +5 more
doaj +3 more sources
Snake venom metalloproteinases and disintegrins: interactions with cells [PDF]
Brazilian Journal of Medical and Biological Research, 1998 Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C ...
Kamiguti A.S. +2 more
doaj +5 more sources
Disintegrins from Hematophagous Sources [PDF]
Toxins, 2012 Bloodsucking arthropods are a rich source of salivary molecules (sialogenins) which inhibit platelet aggregation, neutrophil function and angiogenesis. Here we review the literature on salivary disintegrins and their targets. Disintegrins were first discovered in snake venoms, and were instrumental in our understanding of integrin function and also for
Ivo M. B. Francischetti +2 more
openaire +3 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering [PDF]
Biochemical Journal, 2003 We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO), V. berus (VB), V. ammodytes (VA), Echis ocellatus (EO) and Echis multisquamatus (EMS). Disintegrins VLO4, VB7, VA6 and EO4 displayed the RGD motif and inhibited the adhesion of K562 cells, expressing the integrin α5β1 to ...
Calvete, Juan +4 more
openaire +2 more sources
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
doaj +1 more source