The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family [PDF]
Genome Biology, 2015 The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in ...
Richard J. R. Kelwick +3 more
semanticscholar +10 more sources
Snake Venom Disintegrins and Cell Migration [PDF]
Toxins, 2010 Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement.
Heloisa S. Selistre-de-Araujo +3 more
doaj +4 more sources
Recombinant and Chimeric Disintegrins in Preclinical Research
Toxins, 2018 Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental role in ...
Victor David +5 more
doaj +3 more sources
A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases [PDF]
Frontiers in Cardiovascular Medicine, 2020 Despite recent advances in treatment strategies, infectious diseases are still under the leading causes of death worldwide. Although the activation of the inflammatory cascade is one prerequisite of defense, persistent and exuberant immune response ...
Ahmad Aljohmani, Daniela Yildiz
doaj +3 more sources
ADAM-15 Disintegrin-Like Domain Structure and Function [PDF]
Toxins, 2010 The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu +3 more
doaj +3 more sources
A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems [PDF]
Frontiers in Physiology, 2016 ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins.
Jiaxi Xu +8 more
semanticscholar +5 more sources
How we manage immune‐mediated thrombotic thrombocytopenic purpura after rituximab failure or intolerance [PDF]
British Journal of Haematology, Volume 206, Issue 6, Page 1560-1570, June 2025.The use of rituximab as a pre‐emptive treatment in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is the current standard of care. However, for patients refractory to rituximab or for those with contraindication, further treatment guidelines are scarce.
Julia Weisinger +4 more
wiley +2 more sources
Aprobation of platelet aggregation inhibitor from Echis multisquamatis snake venom in vitro, in vivo and ex vivo [PDF]
Biotechnologia Acta, 2023 Snake venom-derived platelet aggregation inhibitors can be promising antiplatelet medications that can allow to avoid the risk of bleeding and treatment resistance, particularly in aspirin-resistant patients.
Zhelavskyi M. A. +3 more
doaj +1 more source
PACSIN2 Is a Regulator of the Metalloprotease/Disintegrin ADAM13
Developmental Biology, 2001 ADAM13 is a cell surface metalloprotease expressed in cephalic neural crest cells during early Xenopus development. The cytoplasmic domain of ADAM13 contains three potential SH3 (Src homology type 3) binding sites, suggesting that this region may support interactions with intracellular proteins.
Hélène Cousin +4 more
openalex +4 more sources
LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis [PDF]
Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu +8 more
wiley +2 more sources