Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]
, 2015 Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J. +3 more
core +2 more sources
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent [PDF]
, 2008 Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin–rich podosomes.
Chan, Kui Ming +6 more
core +4 more sources
Bioinformatics analysis of structure and function of Lebestatine isolated from Macrovipera venom [PDF]
Journal of Advanced Biomedical Sciences, 2017 Background & Objective: Lebestatin is a new member of disintegrin family. This single-chain poly peptide comprises 107 amino acids isolated from Macrovipera venom.
Maryam Rabiee +2 more
doaj
EVALUATING THE EFFECTS OF DISINTEGRIN ON TUMOUR GROWTH [PDF]
Biotechnologia ActaCancer is the second leading cause of death in the world after cardiovascular disease, and many types of cancer have no symptoms in the early stages, making it difficult to diagnose.
O. M. PLATONOV, Y. D. VINNYCHUK
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1999 Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP).
S. Lammich +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou +14 more
wiley +1 more source
Nucleotide sequence of a cDNA encoding a common precursor of disintegrin flavostatin and hemorrhagic factor HR2a from the venom of Trimeresurus flavoviridis [PDF]
, 1999 The venom of Trimeresurus flavoviridis has three disintegrins that act as platelet aggregation inhibitors by binding to integrin αIIbβ3 on platelets through its Arg-Gly-Asp sequence.
Morita, Takashi +2 more
core +1 more source
The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches
Molecules, 2022 Snake venom contains a number of active molecules that have been shown to possess high anti-tumor activities; disintegrins are an excellent example among these.
Oussema Khamessi +5 more
doaj +1 more source
Inhibition of adipogenesis by RGD-dependent disintegrin
Biochemical Pharmacology, 2005 Adipogenesis plays a central role in obesity development. The processes of adipogenesis include migration, adhesion, proliferation and survival of preadipocytes and differentiation to mature adipocytes. Many of these biological functions are related to integrins.
Lin, Yu-Ting +5 more
openaire +3 more sources
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source