Application of the Thermal Analysis of Frozen Aqueous Solutions to Assess the Miscibility of Hyaluronic Acid and Polymers Used for Dissolving Microneedles [PDF]
PharmaceuticsBackground: The combination of multiple polymers is anticipated to serve as a means to diversify the physical properties and functionalities of dissolving microneedles. The mixing state of components is considered as a crucial factor in determining their
Ken-ichi Izutsu +5 more
doaj +2 more sources
Development of Quercetin Solid Dispersion-Loaded Dissolving Microneedles and In Vitro Investigation of Their Anti-Melanoma Activities [PDF]
PharmaceuticsBackground: Melanoma is a skin cancer that requires early treatment to prevent metastasis. In particular, the superficial spreading melanoma, excisional surgery with local administration of anti-cancer drugs via microneedles is currently considered a ...
Monsicha Khuanekkaphan +3 more
doaj +2 more sources
Rapidly Dissolving Microneedles Incorporating Lidocaine Hydrochloride: A PVP/PVA-Based Approach for Local Anesthesia [PDF]
PharmaceuticsBackground/Objectives: Lidocaine is a widely used local anesthetic, but injections and topical creams are often painful or slow in onset. This study aimed to develop dissolving microneedles incorporating lidocaine hydrochloride for rapid and convenient ...
Su Young Jin +4 more
doaj +2 more sources
Delivery of PLGA-Loaded Influenza Vaccine Microparticles Using Dissolving Microneedles Induces a Robust Immune Response [PDF]
PharmaceuticsBackground: Influenza virus is one of the major respiratory virus infections that is a global health concern. Although there are already approved vaccines, most are administered via the intramuscular route, which is usually painful, leading to vaccine ...
Emmanuel Adediran +10 more
doaj +2 more sources
The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles [PDF]
PharmaceuticsTransdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter the challenge of a low transdermal absorption rate.
Ziyao Chang +7 more
doaj +2 more sources
Mechanical properties and immunotherapeutic effects of dissolving microneedles with different drug loadings based on hyaluronic acid [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2023 Improving vaccine immunity and reducing antigen usage are major challenges in the clinical application of vaccines. Microneedles have been proven to be painless, minimally invasive, highly efficient, and have good patient compliance.
Dazhi Wang +5 more
doaj +1 more source
Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen [PDF]
Pharmaceuticals, 2023 Ryan F Donnelly +2 more
exaly +2 more sources
A Perspective on Imiquimod Microneedles for Treating Warts
Pharmaceutics, 2021 Warts are a common skin problem and are caused by infection with a virus. Warts are currently mainly treated by therapies involving ablating tissue or interrupting cellular division.
Tsu-Man Chiu +7 more
doaj +1 more source
Dissolving Microneedle Patches for Dermal Vaccination [PDF]
Pharmaceutical Research, 2017 The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or
Leone, M. +3 more
openaire +3 more sources
Dissolving microneedles for transdermal drug delivery [PDF]
Biomaterials, 2008 Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines. This study presents a design that encapsulates molecules within microneedles that dissolve within the skin for bolus or sustained delivery and leave behind ...
Jeong W, Lee +2 more
openaire +2 more sources