Results 81 to 90 of about 15,452 (227)

Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme [PDF]

Neuro-Oncology, 2013
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by massive neovascularization, necrosis, and intense resistance to therapy. Deregulated Notch signaling has been implicated in the formation and progression of different malignancies. The present study attempted to investigate the activation status of Dll4-Notch signaling in
El Hindy, N., Keyvani, Kathy, Pagenstecher, A., Dammann, Philipp, Sandalcioglu, Erol, Sure, Ulrich, Zhu, Yuan   +6 more
openaire   +3 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley   +1 more source

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis [PDF]

, 2015
Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to ...
Angulo Aguado, Ana, Casanovas i Casanovas, Oriol, Friedman, Lori S., Gerhardt, Holger, Graupera i Garcia-Milà, Mariona, Guillermet-Guibert, Julie, Pearce, Wayne, Serra, Helena, Soler, Adriana, Vanhaesebroeck, Bart, Viñals Canals, Francesc   +10 more
core   +1 more source

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, Volume 177, Issue 4, Page 810-823, April 2026.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis ‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Matrix Gla Protein Reinforces Angiogenic Resolution [PDF]

, 2013
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear.
Albig, Allan R., Sharma, Bikram
core   +2 more sources

TMZ regulates GBM stemness via MMP14‐DLL4‐Notch3 pathway [PDF]

International Journal of Cancer, 2019
Glioblastoma (GBM) is one of the most aggressive primary brain tumors with frequent recurrences following the standard methods of treatment—temozolomide (TMZ), ionizing radiation and surgical resection. The objective of our study was to investigate GBM resistance mediated via MMP14 (matrix metalloproteinase 14).
Ilya V. Ulasov, Olja Mijanovic, Solomiia Savchuk, Edgar Gonzalez‐Buendia, Adam Sonabend, Ting Xiao, Petr Timashev, Maciej S. Lesniak   +7 more
openaire   +2 more sources

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor

Chinese Journal of Lung Cancer, 2009
Background and objective Angiogenesis depends on the interaction of a variety of promoting factors and inhibiting factors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway take part in this process.
Xiaoping LI, Qingfu ZHANG, Bin LU, Xueshan QIU, Yang LUO, Weidong ZHANG, Shun XU   +6 more
doaj  

M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn's Disease [PDF]

, 2016
Background: The Notch signalling pathway plays an essential role in mucosal regeneration, which constitutes a key goal of Crohn's disease (CD) treatment.
Alós Company, Rafael, Barrachina Sancho, María Dolores, Calatayud Romero, Sara, Cosín Roger, Jesús, Esplugues Mota, Juan Vicente, Hernández, C., Hinojosa, Joaquin, Ortiz Masiá, María Dolores   +7 more
core   +1 more source