Results 11 to 20 of about 3,128,275 (354)

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue [PDF]

Clinical Epigenetics, 2017
Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases.
Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon   +8 more
doaj   +3 more sources

Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair. [PDF]

Theranostics, 2022
The efficiency of gene therapy is often dictated by the gene delivery system. Cationic polymers are essential elements of gene delivery systems. The relatively cheap cationic polymer, polyethyleneimine, has high gene delivery efficiency and is often used
Kim HJ, Cho HB, Lee S, Lyu J, Kim HR, Lee S, Park JI, Park KH.   +7 more
europepmc   +2 more sources

Mitochondrial Dna Replacement Versus Nuclear Dna Persistence [PDF]

, 2006
In this paper we consider two populations whose generations are not overlapping and whose size is large. The number of males and females in both populations is constant. Any generation is replaced by a new one and any individual has two parents for what concerns nuclear DNA and a single one (the mother) for what concerns mtDNA.
Cann R L, Kingman J F C, Maurizio Serva, Serva M, Serva M, Simon D, Thorne A G   +6 more
arxiv   +3 more sources

Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]

Electrophoresis 27 (04/2006) 1574-83, 2006
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B cell line and on its Rho-0 ...
Abdul, Appleby, Armstrong, Bai, Bourges, Buchet, Chai, Claros, Da Cruz, Dey, Du, Garcia, Gianazza, Joseph, King, King, Lescuyer, Luche, Manjasetty, Martinus, Perkins, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Santoni, Sharma, Sharp, Sherer, Singh, Sinha, Suzuki, Tastet, Taylor, Tryoen-Toth, Ugalde, Wiedemann, Zamzami, Zischka   +39 more
arxiv   +6 more sources

Mitochondrial DNA: the overlooked oncogenome? [PDF]

BMC Biology, 2019
Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial genome. Recent large-scale sequencing efforts and clinical studies have highlighted the prevalence of
Gammage, Payam A., Frezza, Christian
openaire   +7 more sources

Evidence for variation in the effective population size of animal mitochondrial DNA [PDF]

, 2009
Background: It has recently been shown that levels of diversity in mitochondrial DNA are remarkably constant across animals of diverse census population sizes and ecologies, which has led to the suggestion that the effective population of mitochondrial ...
A Eyre-Walker, A Eyre-Walker, Adam Eyre-Walker, B Nabholz, B Nabholz, CD Millar, CJ Mulligan, E Bazin, E Bazin, E Nevo, Gwenael Piganeau, J Maynard Smith, JD Thompson, JH Gillespie, JH Gillespie, JJ Welch, K Popadin, K Tamura, L Bromham, L Chao, M Albu, MC Whitlock, MJ Benton, N Bierne, N Galtier, Neil John Gemmell, PD Keightley, RC Lewontin, W Jia   +28 more
core   +19 more sources

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

bioRxiv, 2023
Somatic variation contributes to biological heterogeneity by modulating cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor ...
Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, R. Dhindsa, Anne-Sophie Gribling-Burrer, Yu-Hsin Hsieh, Lena Nitsch, Frank A. Buquicchio, Tsion Abay, Sebastian Zielinski, Robert R. Stickels, Jacob C. Ulirsch, Patrick K. Yan, Fangyi Wang, Zhuang Miao, Katalin D. Sandor, Bence Daniel, Vincent Liu, Quanli Wang, Fengyuan Hu, Katherine R Smith, S. V. Deevi, P. Maschmeyer, S. Petrovski, R. Smyth, William J. Greenleaf, Anshul Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy   +29 more
semanticscholar   +1 more source

Mitochondrial DNA Methylation and Human Diseases

International Journal of Molecular Sciences, 2021
Epigenetic modifications of the nuclear genome, including DNA methylation, histone modifications and non-coding RNA post-transcriptional regulation, are increasingly being involved in the pathogenesis of several human diseases.
Andrea Stoccoro, F. Coppedè
semanticscholar   +1 more source

Mitochondrial DNA in inflammation and immunity

EMBO Reports, 2020
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation.
Joel S. Riley, S. Tait
semanticscholar   +1 more source

Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.

Molecular biology and evolution, 1993
Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as
Kazuko Tamura, M. Nei
semanticscholar   +1 more source