Eukaryotic cell viability highly relies on genome stability and DNA integrity maintenance. The cellular response to DNA damage mainly consists of six biological conserved pathways known as homologous recombination repair (HRR), non-homologous end-joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and ...
Christian Weber+7 more
openaire +3 more sources
ABSTRACT Inland recirculating aquaculture is a thriving food industry providing sustainable and locally sourced high‐quality protein. However, its expansion is accompanied by emerging challenges regarding the spread of pathogens and diseases. Detection and management of pathogens in aquaculture remain underdeveloped compared to other animal farming ...
Jessica Rieder+3 more
wiley +1 more source
Kinetoplast DNA‐aggregating proteins from the parasitic protozoan Crithidia fasciculata
Proteins from C. fasciculata, which preferentially aggregate the parasite's AT‐rich mitochondrial (kinetoplast) DNA in vitro, are reported. The aggregation is non‐topological, non‐covalent, independent of Mg2+ and ATP, but much improved by spennidine. We discuss how these proteins might modulate the shape and size of the parasite's mitochondrial genome.
openaire +2 more sources
Position Effect Takes Precedence Over Target Sequence in Determination of Adenine Methylation Patterns in the Nuclear Genome of a Eukaryote, \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]
Approximately 0.8% of the adenine residues in the macronuclear DNA of the ciliated protozoan Tetrahymena thermophila are modified to N6-methyladenine. DNA methylation is site specific and the pattern of methylation is constant between clonal cell lines ...
Karrer, Kathleen M.+1 more
core +1 more source
Cost‐Effective Nanosensor Solutions for Ultra‐Sensitive Detection of Metronidazole
ABSTRACT Metronidazole (MNZ) is a widely used imidazole antibiotic effective against bacterial and protozoal infections, including giardiasis, trichomoniasis, bacterial vaginosis, and antibiotic‐associated colitis. However, prolonged and excessive use of MNZ can lead to serious side effects, such as peripheral neuropathies, toxicity, and optic ...
Ahmad Mobed+6 more
wiley +1 more source
Detection of enteric parasite DNA in household and bed dust samples: potential for infection transmission. [PDF]
BACKGROUND: Enteric parasites are transmitted in households but few studies have sampled inside households for parasites and none have used sensitive molecular methods.
Calderón, E+5 more
core +1 more source
Can Unicellular Organisms Sequester a Germline? The Yeast‐Germline Hypothesis
Asymmetrical inheritance of template‐DNA and copy‐DNA strands during mitosis can reduce the number of mutant cells. This requires that cells continuing to divide inherit the “immortal” template‐DNA, while their daughter cells become quiescent and inherit copy‐DNA strands.
Bhavya Sree Vadlamudi, Duur K. Aanen
wiley +1 more source
Description of a new actinosporean type from South African freshwater [PDF]
The 1st report on actinospores described these organisms as parasites related to myxosporeans. For a long time this group of parasites was believed to represent an independent taxonomic entity.
Avenant-Oldewage, Annemarie+2 more
core +1 more source
Traditional fermented foods in synthetic microbial communities (SynComs). We simulated the production of zha‐chili, a traditional fermented food, in the laboratory, intending to address the following questions: How are SynComs constructed, and what is the effect of inoculation with SynComs on the quality of zha‐chilli? How does inoculation with SynComs
Hongye Shen+7 more
wiley +1 more source
Germ Line-Specific DNA Sequences are Present on All Five Micronuclear Chromosomes in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]
The development of the macronucleus from the zygotic micronucleus in the ciliated protozoan Tetrahymena spp. involves the elimination of specific DNA sequences (M. C. Yao and M. Gorovsky, Chromosoma 48:1-18 1974).
Karrer, Kathleen M.
core +1 more source