Results 71 to 80 of about 44,514 (187)

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

Molecular Genetics of Hepatozoon canis With a Note on Effect of Parasite on the Complete Blood Count Profile of Canine Hosts

Ecology and Evolution, Volume 16, Issue 8, August 2026.
A total of 654 blood samples were collected from healthy dogs in Punjab and Khyber Pakhtunkhwa provinces in Pakistan and screened for the presence of Hepatozoon canis. Genetic diversity of the detected H. canis DNA, infection‐associated risk factors, and changes in the complete blood count of the host due to parasitic activity were also evaluated.
Madiha Rasool, Muhammad Latif, Ioannis A. Giantsisis, Muhammad Ali, Hira Muqaddas, Muhammad Naeem, Sami Ul Haq, Gehan M. Elossaily, Esmael M. Alyami, Mona Alsolami, Ousman Brahim Mahamat, Irfan Ullah, Asmat Ullah Khan, Adil Khan, Furhan Iqbal   +14 more
wiley   +1 more source

Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo

Mediators of Inflammation, 2016
Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens.
Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla   +5 more
doaj   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Mitochondrial Genome Reduction and Accelerated Evolution in Planktonic Foraminiferans

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
The mitochondrial genomes of the eukaryotic lineage Retaria (Foraminifera and Radiolaria) show reductions in multiple gene categories, including complex I, transfer RNAs (tRNAs), ribosomal proteins, and ribosomal RNAs. In planktonic foraminifera, this reduction is even more pronounced, with the potential loss of atp and other genes.
Hsin‐Tung Lai, Ming‐Wei Lai, Tzu‐Haw Wang, Haojia Ren, Chuan Ku   +4 more
wiley   +1 more source

Neutrophils Cast Extracellular Traps in Response to Protozoan Parasites

Frontiers in Immunology, 2012
Release of extracellular traps by neutrophils is a now well-established phenomenon that contributes to the innate response to extracellular bacterial and fungal pathogens.
Eric eDenkers, Delbert eAbi Abdallah
doaj   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

DNA repair mechanisms in eukaryotes: Special focus in Entamoeba histolytica and related protozoan parasites

Infection, Genetics and Evolution, 2009
Eukaryotic cell viability highly relies on genome stability and DNA integrity maintenance. The cellular response to DNA damage mainly consists of six biological conserved pathways known as homologous recombination repair (HRR), non-homologous end-joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and ...
César, López-Camarillo, Mavil, Lopez-Casamichana, Christian, Weber, Nancy, Guillen, Esther, Orozco, Laurence A, Marchat   +5 more
openaire   +2 more sources

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source