Results 31 to 40 of about 2,258,474 (352)
BMC Cancer, 2020 Background Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins.
Manthan Patel +3 more
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Predicting target DNA sequences of DNA-binding proteins based on unbound structures. [PDF]
PLoS ONE, 2012 DNA-binding proteins such as transcription factors use DNA-binding domains (DBDs) to bind to specific sequences in the genome to initiate many important biological functions.
Chien-Yu Chen +5 more
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Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]
, 1998 Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E. +6 more
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PLoS Genetics, 2019 Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In higher eukaryotes, it remains unclear how the duration of TF binding to DNA relates to downstream ...
Andrea Callegari +6 more
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Characterization of the DNA binding activity of structural protein VP1 from chicken anaemia virus
BMC Veterinary Research, 2018 Background Chicken anaemia virus (CAV) is commonly found in poultry. VP1 is the sole structural protein of CAV, which is the major component responsible for capsid assembly. The CAV virion consists of the VP1 protein and a viral genome. However, there is
Guan-Hua Lai +7 more
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Biomolecules, 2020 Saccharomyces cerevisiae does not contain a p53 homolog. Utilizing this yeast as an in vivo test tube model, our aim was to investigate if a yeast protein would show p53 DNA binding homology. Electrophoretic mobility shift analyses revealed the formation
Kanwal Farooqi +7 more
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DNA-binding activity of papillomavirus proteins [PDF]
Journal of Virology, 1987 We demonstrate DNA binding by papillomavirus (PV) open reading frame (ORF) proteins that correspond to the early transforming and trans-activating (E6 and E2) and late structural regions (L2 and L1) from bovine PV type 1 and human PV types 6b and 16.
R G, Mallon +2 more
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The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation [PDF]
, 1988 The immediate-early (IE) protein Vmw175 (ICP4) of HSV-1 is required for the transcription of later classes of viral genes and the repression of IE gene expression.
Everett, R.D., Paterson, T.
core +1 more source
Calling cards for DNA-binding proteins [PDF]
Genome Research, 2007 Identifying genomic targets of transcription factors is fundamental for understanding transcriptional regulatory networks. Current technology enables identification of all targets of a single transcription factor, but there is no realistic way to achieve the converse: identification of all proteins that bind to a promoter of interest. We have developed
Wang, Haoyi +2 more
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DNA-binding residues and binding mode prediction with binding-mechanism concerned models
BMC Genomics, 2009 Background Protein-DNA interactions are essential for fundamental biological activities including DNA transcription, replication, packaging, repair and rearrangement.
Oyang Yen-Jen +4 more
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