Results 51 to 60 of about 2,121,701 (315)

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Fili, Natalia, Webb, Martin R, Mashanov, Gregory I, Chisty, Liisa T, Toseland, Christopher P., Dillingham, Mark S, Toseland, Christopher P, Molloy, Justin E   +7 more
core   +1 more source

MIDA1 is a sequence specific DNA binding protein with novel DNA binding properties [PDF]

Genes to Cells, 2000
BackgroundId proteins not only regulate cell differentiation negatively, but they also promote growth and apoptosis. To know the mechanism of how Id regulates cell fate, we previously isolated an Id‐associating protein, MIDA1, which positively regulates cell growth.
T, Inoue, W, Shoji, M, Obinata
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.

, 2015
Ets transcription factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in humans and are particularly involved in developmental processes.
Allerston, Charles K., Gileadi, Opher, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +4 more
core   +1 more source

Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. [PDF]

PLoS Pathogens, 2011
Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the gene encoding the control of virulence regulator (CovR) protein.
Nicola Horstmann, Pranoti Sahasrabhojane, Bryce Suber, Muthiah Kumaraswami, Randall J Olsen, Anthony Flores, James M Musser, Richard G Brennan, Samuel A Shelburne   +8 more
doaj   +1 more source

DeepMC-iNABP: Deep learning for multiclass identification and classification of nucleic acid-binding proteins

Computational and Structural Biotechnology Journal, 2022
Nucleic acid-binding proteins (NABPs), including DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs), play vital roles in gene expression. Accurate identification of these proteins is crucial.
Feifei Cui, Shuang Li, Zilong Zhang, Miaomiao Sui, Chen Cao, Abd El-Latif Hesham, Quan Zou   +6 more
doaj   +1 more source

Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins [PDF]

Nucleic Acids Research, 2003
A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting DNA-binding sites using a single feature of these surface patches. Surface patches and the DNA-binding
Jones, S, Shanahan, H P, Berman, H M, Thornton, J M   +3 more
openaire   +8 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Knockdown of Ubiquitin-Specific Protease 53 Enhances the Radiosensitivity of Human Cervical Squamous Cell Carcinoma by Regulating DNA Damage-Binding Protein 2

Technology in Cancer Research & Treatment, 2020
Background: Cervical cancer ranks fourth in incidence and mortality among women. Ubiquitin-specific protein 53 binds to damage-specific DNA binding protein 2 and affects the biological properties of colon cancer.
Qifen Zhou MM, Xiongbo Yao MM, Chunlin Wu AP, Shaohua Chen MM, Dage Fan MM   +4 more
doaj   +1 more source

Thermodynamic analysis of DNA binding by a Bacillus single stranded DNA binding protein [PDF]

BMC Biochemistry, 2012
Single-stranded DNA binding proteins (SSB) are essential for DNA replication, repair, and recombination in all organisms. SSB works in concert with a variety of DNA metabolizing enzymes such as DNA polymerase.We have cloned and purified SSB from Bacillus anthracis (SSB(BA)).
Biswas, Esther E, Kukiratirat, Jirayu, Biswas, Subhasis B   +2 more
openaire   +2 more sources