Results 11 to 20 of about 108,714 (328)
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. [PDF]
PLoS ONE, 2014 We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme's active ...
Scott T Kimber, Tom Brown, Keith R Fox
doaj +1 more source
Structure of mouse DNA (cytosine-5-)-methyltransferase [PDF]
European Journal of Biochemistry, 1988 DNA (cytosine‐5‐)‐methyltransferase was purified as a single polypeptide (190 kDa by SDS‐PAGE) from mouse P815 mastocytoma cells. This enzyme transfers methyl groups to unmethylated as well as to hemimethylated DNA sites with a strong preference for the hemimethylated substrate.
E, Spiess +3 more
openaire +2 more sources
Acceleration of the Deamination of Cytosine through Photo-Crosslinking
Current Issues in Molecular Biology, 2023 Herein, we report the major factor for deamination reaction rate acceleration, i.e., hydrophilicity, by using various 5-substituted target cytosines and by carrying out deamination at high temperatures.
Siddhant Sethi +5 more
doaj +1 more source
Epigenetics, 2021 The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently observed that in 5-hydroxymethyl cytosine sequences, DNA methylation is dependent on the co-presence
Andigoni Malousi +2 more
doaj +1 more source
eLife, 2021 Shotgun metagenomic sequencing is a powerful approach to study microbiomes in an unbiased manner and of increasing relevance for identifying novel enzymatic functions.
Weiwei Yang +9 more
doaj +1 more source
DNMT1 (DNA (cytosine-5-)-methyltransferase 1)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on DNMT1 (DNA (cytosine-5-)-methyltransferase 1)), with data on DNA, on the protein encoded, and where the gene is implicated.
Arai, E, Kanai, Y
openaire +2 more sources
Cells, 2023 DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic ...
I. Emon +3 more
semanticscholar +1 more source
PLoS ONE, 2022 5-Methylcytosine is one of the major epigenetic marks of DNA in living organisms. Some bacterial species possess DNA methyltransferases that modify cytosines on both strands to produce fully-methylated sites or on either strand to produce hemi-methylated
Y. Furuta +9 more
semanticscholar +1 more source
Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer [PDF]
, 2013 Change of DNA cytosine methylation (5mC) is an early event in the development of cancer, and the recent discovery of a 5-hydroxymethylated form (5hmC) of cytosine suggests a regulatory epigenetic role that might be different from 5-methylcytosine.
Matthias, Wielscher +7 more
core +1 more source
Journal of Molecular Biology, 1997 The mechanisms that establish and maintain methylation patterns in the mammalian genome are very poorly understood, even though perturbations of methylation patterns lead to a loss of genomic imprinting, ectopic X chromosome inactivation, and death of ...
Jeffrey A. Yoder +3 more
semanticscholar +1 more source